Method and system for microbiome-derived characterization, diagnostics and therapeutics for conditions associated with functional features

A method for at least one of characterizing, diagnosing, and treating an aminobenzoate-related condition for a subject, the method comprising:

• for a set of samples comprising at least one sample associated with the aminobenzoate-related condition:
• determining microorganism nucleic acid sequences, comprising:
• selecting primers for nucleic acid sequences associated with the aminobenzoate-related condition,
• amplifying nucleic acid material from the samples based on the primers;
• and
• determining alignments of the microorganism nucleic acid sequences to reference sequences;
• generating a microbiome functional diversity dataset based on the alignments;
• extracting a set of microbiome functional diversity features from the microbiome functional diversity dataset;
• generating a characterization of the aminobenzoate-related condition based on the set of microbiome functional diversity features;
• determining a therapy for the subject based on the characterization and a subject sample from the subject;
• and
• providing the therapy to the subject, wherein the therapy is operable to modulate microbiome composition to improve a state of the aminobenzoate-related condition.