Recombinant HVT vectors expressing multiple antigens of avian pathogens and uses thereof
AssigneeBoehringer Ingelheim Animal Health USA Inc.
InventorsMichel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
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Abstract
The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
Claims24
A composition or vaccine comprising a recombinant herpesvirus of turkeys (HVT) vector comprising a first heterologous polynucleotide coding for and expressing an Infectious Laryngotracheitis Virus (ILTV) glycoprotein D (gD) antigen, wherein the ILTV gD antigen has at least 80% sequence identity to SEQ ID NO:17, the first heterologous polynucleotide has at least 70% sequence identity to SEQ ID NO:16, or both.
A recombinant HVT vector comprising:
- a first heterologous polynucleotide coding for and expressing an Infectious Laryngotracheitis Virus (ILTV) glycoprotein D (gD) antigen, wherein the ILTV gD antigen coded by the first heterologous polynucleotide has at least 80% sequence identity to SEQ ID NO:17, the first heterologous polynucleotide has at least 70% sequence identity to SEQ ID NO:
- 16, or both;
- and a second heterologous polynucleotide coding for and expressing an Infectious Burial Disease Virus (IBDV) VP2 antigen, an Infectious Laryngotracheitis Virus (ILTV) glycoprotein D (gD) antigen, or a Newcastle Disease Virus F (NDV-F) antigen.
Dependencies are inferred from the claim text.