Hepatitis B virus pre-S1 derived synthetic polypeptides and uses thereof
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Stephan Urban
InventorsPhilippe Gripon, Stephan Urban
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Abstract
The invention relates to a group of synthetic polypeptides, derived from the pre-S1 region of HBV, that efficiently interfere with early steps of an HBV infection. The peptides of the invention can be used in diagnostics for the detection of antigens and/or antibodies.
Claims24
A method for treating a subject having a HBV infection, comprising administering to the subject a synthetic polypeptide of formula (I)
- X—Y—Z (I)
- wherein
- X is an amino acid, or absent;
- Y is the amino acid sequence consisting of the amino acid starting at position 2 and ending at an amino acid between position 28 and position 48 of a pre-S1 region of HBV large (L) envelope protein corresponding to SEQ ID NO:1 or a variant thereof, wherein the variant has a homologous sequence in viral species, strains or subtypes of HBV large (L) envelope protein;
- Z, linked to the —CO— group of the last residue of Y, is absent, or is the amino acid sequence consisting of the amino acid starting at position 49 and ending at an amino acid between position 49 and position 78 of pre-S1 region of HBV L envelope protein corresponding to SEQ ID NO:1 or a variant thereof, wherein the variant has a homologous sequence in viral species, strains or subtypes of HBV large (L) envelope protein, if the amino acid sequence of Y includes the amino acid at position 48;
- and wherein said polypeptide is chemically attached to a hydrophobic moiety that is a fatty acid or a cholesterol.
A method for treating a subject having a HBV infection, comprising the step of administering to the subject a synthetic polypeptide that is chemically modified to bear a hydrophobic moiety that is a fatty acid or a cholesterol, wherein the synthetic polypeptide consists of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 13, and SEQ ID NO:
- 14.
A method for treating a subject having a HBV infection, comprising the step of administering to the subject a synthetic polypeptide consisting of SEQ ID NO:
- 2 that is chemically modified to bear a hydrophobic moiety that is a fatty acid or a cholesterol.
Dependencies are inferred from the claim text.