Water-soluble UV-absorbing compounds and uses thereof
AssigneeNovartis AG
InventorsFrank Chang, Ryan DeSousa, Troy Vernon Holland, Walter R. Laredo
Life of this patent
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Abstract
Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.
Claims11
An acetal-containing, UV-absorbing compound of any one of formula (I) to (V)
- in which:
- Ra is CH3 or C2H5;
- Ro is H or CH3;
- R1, R2 and R2′ independent of one other are H, CH3, CCl3, CF3, Cl, Br, NR′R″ in which R′ and R″ independent of each other are H or C1-C4 alkyl, OH, or OCH3;
- R1′ independent of each other are H, CH3, CCl3, CF3, Cl, Br, NR′R″ in which R′ and R″ independent of each other are H or C1-C4 alkyl, OH, OCH3, SO3H, or SO3−Na+;
- R3 and R4 independent of each other are H or a first hydrophilic group which is
- provided that at least one of R3 and R4 is the first hydrophilic group;
- r1 is an integer of 1 to 8;
- n1 is an integer of 2 to 20;
- R5 is H, *—COOH, *CONH—C2H4(OC2H4)n1—OCH3, or —CONH—C2H4—(OC2H4)n1—OH;
- one of R6 and R7 is H or a second hydrophilic group which is
- while the other of R6 and R7 is
- R8 is CH3, C2H5,
- R9 is SO3Na,
- R9′ is H, SO3Na,
- R10 is methyl or ethyl;
- L1 is a linkage of
- L2 is a linkage of
- L3 is a linkage of
- and
- X1 is O or NRo.
Dependencies are inferred from the claim text.