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US 10,316,432 B2Granted
Electrospinning of peptide amphiphiles
AssigneeNorthwestern University
InventorsAlok S. Tayi, E. Thomas Pashuck, III, Samuel I. Stupp
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Abstract
Provided herein are methods for the manufacture of fibers from solution-phase peptide-based polymers by electrospinning, and compositions produced thereby. In particular embodiments, various embodiments provide electrospinning supramolecular fibers from low concentration peptide amphiphile filaments.
Claims6
A method of manufacturing fibers of peptide amphiphiles comprising:
- (a) dissolving peptide amphiphiles in solvent under conditions such that the peptide amphiphiles form nanofilaments, wherein the peptide amphiphiles comprise a non-peptide lipophilic segment, a β-sheet-forming peptide segment, and a charged peptide segment;
- and
- (b) electrospinning the nanofilaments to produce fiber.
Dependencies are inferred from the claim text.