Isothiocyanate compounds and isothiocyanate XPO1 protein inhibitor drugs thereof

An isothiocyanate compound of formula I:

• wherein R is selected from phenyl, a five- to six-membered mononuclear heteroaryl including 1-3 heteroatoms each independently selected from nitrogen, oxygen or sulfur, an eight- to ten-membered dinuclear aryl, an eight- to ten-membered dinuclear heteroaryl including 1-4 heteroatoms each independently selected from nitrogen, oxygen or sulfur, a ten- to fourteen-membered trinuclear aryl, or a ten- to fourteen-membered trinuclear heteroaryl including 1-4 heteroatoms each independently selected from nitrogen, oxygen or sulfur;
• wherein R is unsubstituted, or is optionally substituted with one or more independently selected W substituents,
• wherein the W substituent is selected from halogen, C1-4 alkoxy, C1-4 haloalkyl, a five- to six-membered mononuclear heteroaryl including 1-3 heteroatoms, each independently selected from nitrogen, oxygen or sulfur, a four- to seven-membered heterocycloalkyl, including 1-3 heteroatoms, each independently selected from nitrogen, oxygen or sulfur, or an eight- to ten-membered dinuclear heteroaryl including 1-4 heteroatoms, each independently selected from nitrogen, oxygen or sulfur;
• and
• wherein n is 0, 1 or 2.