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US 10,315,016 B2Granted
System and methods for treating MVO
AssigneeCorFlow Therapeutics AG
InventorsRobert S. Schwartz, Martin T. Rothman, Jon H. Hoem
Life of this patent
Estimating the term…
Abstract
Microvascular obstruction is treated by introducing injectate into blood vessels affected by microvascular obstruction at precise flow rates, while blocking retrograde flow, such that the natural pumping of the heart aids in forcing the injectate into the affected microvessels. Monitoring pressure distal of an occlusion balloon is used to determine treatment effectiveness and heart health.
Claims23
A method for treating Microvascular Obstruction (MVO) comprising:
- navigating a catheter into a myocardial vessel supplying blood to a patient's myocardium with MVO;
- blocking antegrade and retrograde blood flow within the vessel around said catheter using a balloon;
- measuring a fluid pressure of the myocardial vessel occurring distal of the balloon;
- introducing infusate through a lumen of said catheter at predetermined flow rates;
- allowing natural myocardial contraction and compression of microvasculature to pump the infusate antegrade into occluded myocardial vessels and to promote mixing of the infusate with obstructing matter causing MVO;
- collecting data pertinent to pressure parameters in the myocardial vessel;
- analyzing the collected data to determine a change resulting from said treating the MVO.
4 more elements
A method of reestablishing blood flow through occluded microvessels comprising:
- navigating a catheter into a vessel supplying blood to the occluded vessels;
- blocking antegrade and retrograde blood flow around a distal end of said catheter;
- monitoring at least one of a pressure inside the catheter, and a pressure outside a distal end of the catheter;
- pumping infusate through a lumen of said catheter in a patterned response having a pattern that is selected based on at least one monitored pressure;
- preventing retrograde flow of the infusate around the catheter such that natural cardiac contractions at least partially aid in pumping the infusate antegrade into the occluded vessels;
- altering the pattern as the at least one monitored flow, pressure or resistance change;
- analyzing data collected during the monitoring step to determine whether and to what extent blood flow has been reestablished.
4 more elements
Dependencies are inferred from the claim text.