Virus-like particle compositions and vaccines against Epstein-Barr virus infection and disease
AssigneeUniversity of Massachusetts
InventorsJavier Gordon Ogembo, Trudy Morrison
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Abstract
The present inaveation relates to prophylactic and/or therapeutic vaccines thatpoatairj Newcastle disease Virus (NDV) virus-like particles (VLPs) comprising one or more Epstein-Barr Virus (EBV) antigens, in one embodiment, the invention provides a recombinant virus-like particle (V'UP) comprising, i is operable combination, a) Newcastle disease virusΛ iNDVj matrix (M) protein, and b) one or more Epstein-Barr Virus (BBV) antigens. The im'eniion's prophylactic and/or therapeutic vacclrses are useful for preventing asc/or treatmg, infection with EBY aixi/or disease associated Epstein-Barr Virus, such as cancer.
Claims23
A recombinant virus-like particle (VLP) comprising, in operable combination,
- a) Newcastle disease virus (NDV) matrix (M) protein,
- b) NDV nucleocapsid (NP) protein, and
- c) one or more tumor-associated EBV antigen,
- wherein said one or more tumor-associated EBV antigen is fused to the C-terminal end of said NDV NP protein and is inside said VLP.
Dependencies are inferred from the claim text.