Methods for enhancing efficacy of a vaccine by administering an IL-4R antagonist
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsLisa Purcell, Neil Graham, Andrew J. Murphy, Robert Evans
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Abstract
The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.
Claims21
A method for enhancing the efficacy or safety, or both of a vaccine comprising:
- (a) selecting a subject that is susceptible to a pertussis infection;
- and
- (b) administering a vaccine specific to the pertussis infection in combination with an IL-4R antagonist to the subject, wherein the IL-4R antagonist is an antibody or antigen-binding fragment thereof that binds IL-4Rα, and comprises three HCDRs (HCDR1, HCDR2 and HCDR3) and three LCDRs (LCDR1, LCDR2 and LCDR3), wherein the HCDR1 comprises the amino acid sequence of SEQ ID NO:
- 3;
- the HCDR2 comprises the amino acid sequence of SEQ ID NO:
- 4;
- the HCDR3 comprises the amino acid sequence of SEQ ID NO:
- 5;
- the LCDR1 comprises the amino acid sequence of SEQ ID NO:
- 6;
- the LCDR2 comprises the amino acid sequence of SEQ ID NO:
- 7;
- and the LCDR3 comprises the amino acid sequence of SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.