# US 10,310,039 B2 · Method and apparatus for multislice magnetic resonance fingerprinting

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- Number: US 10,310,039 B2
- Document ID: US10310039B2
- Status: Granted
- Kind: B2
- Application number: 15/585,456
- Filed: 2017-05-03
- Published: 2017-11-09
- Granted: 2019-06-04
- Earliest claimed: 2016-05-03
- Assignees: Siemens Healthcare GmbH
- Applicants: Siemens Healthcare GmbH
- Inventors: Himanshu Bhat; Mario Zeller
- Web page: https://patentgrep.com/patent/US10310039B2

## CPC

- G01R 33/4835: {of multiple slices}
- G01R 33/4828: {Resolving the MR signals of different chemical species, e.g. water-fat imaging}
- G01R 33/5608: {Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels (image data processing or generation, in general G06T)}
- G01R 33/561: by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)

## Abstract

In a method and magnetic resonance (MR) apparatus for combined multislice fingerprinting MR imaging, for each repetition of a repetition sequence, radio-frequency excitation pulses are radiated with flip angles of the radio-frequency excitation pulses being different from one another, at least for a few repetitions. The scattering of the local maxima of the sum of the radio-frequency energy of the radio-frequency excitation pulses as a function of the repetition over the repetition sequence is for example not greater than 80%.

## Claims

### Claim 1

A method for magnetic resonance (MR) fingerprinting, comprising:
with a computer, operating an MR data acquisition scanner to execute a repetition sequence in a plurality of repetitions and, in each repetition, radiating a first radio-frequency (RF) excitation pulse into an examination subject, situated in the scanner, that excites a magnetization of nuclear spins in a first slice of the subject, and acquiring first MR data resulting from said first RF excitation pulse;
with said computer, operating said scanner, in each repetition, to also radiate a second RF excitation pulse that excites a magnetization of nuclear spins in a second slice of the examination subject, that is different from said first slice, and acquiring second MR data resulting from said second RF excitation pulse;
with said computer, operating said scanner to radiate said first RF excitation pulse and said second RF excitation pulse in the respective repetitions so as to be radiated at least partly in parallel in time and, in at least some of said repetitions, radiating said first RF excitation pulse with flip angle that differs from a flip angle of said second RF excitation pulse;
with said computer, operating said scanner to execute said repetitions of said repetition sequence with a scattering of local maxima of a sum of RF energy of said first RF excitation pulse and said second RF excitation pulse in each repetition, to be less than 80% of an average value of said sum over all of said repetitions of said repetition sequence;
in said computer, determining a first MR image of the first slice based on a fingerprinting directory and said first MR data, and determining a second MR image of the second slice based on said fingerprinting directory and said second MR data; and
making the first MR image and the second MR image available in electronic form from said computer as respective data files.

### Claim 2 (depends on 1)

A method as claimed in claim 1 comprising, with said computer, operating said scanner to vary the respective flip angles of said first RF excitation pulses in different repetitions, and to vary the respective flip angles of said second RF excitation pulse in different repetitions.

### Claim 3 (depends on 1)

A method as claimed in claim 1 comprising, with said computer, operating said scanner to give the flip angle of the first RF excitation pulses in respective repetitions a dependency on the respective repetitions that is complementary to dependency of the respective flip angles of second RF excitation pulses on said respective repetitions.

### Claim 4 (depends on 1)

A method as claimed in claim 1 comprising, with said computer, operating said scanner to give the flip angle of the first RF excitation pulses in respective repetitions a dependency on the respective repetitions that correspond to dependency of the respective flip angles of second RF excitation pulses on said respective repetitions.

### Claim 5 (depends on 4)

A method as claimed in claim 4 wherein the dependency of the respective flip angles of the first RF excitation pulses on the respective repetitions is described by a first function, and wherein the dependency of the flip angles of the second radio-frequency excitation pulses in the respective repetitions is described by a second function, wherein said first function corresponds to said second function.

### Claim 6 (depends on 5)

A method as claimed in claim 5 wherein said first function is equal to said second function multiplied by a scaling factor that is not equal to one.

### Claim 7 (depends on 5)

A method as claimed in claim 5 wherein said first function is equal to said second function displaced by at least one repetition.

### Claim 8 (depends on 5)

A method as claimed in claim 5 wherein said first and second functions have oscillations with a periodicity that is dependent on the respective repetitions.

### Claim 9 (depends on 1)

A method as claimed in claim 1 wherein said scattering of the local maxima of the sum of RF energy of said first RF excitation pulse and said second RF excitation pulse in each repetition is no larger than 50% of said average value of said sum over all of said repetitions of said repetition sequence.

### Claim 10 (depends on 1)

A method as claimed in claim 1 wherein a scattering of the sum of the RF energy of the first RF excitation pulse and the RF energy of the second RF excitation pulse in each repetition is less than 20% of an average value of said sum over all of said repetitions of said repetition sequence.

### Claim 11 (depends on 1)

A method as claimed in claim 1 wherein a scattering of the sum of the RF energy of the first RF excitation pulse and the RF energy of the second RF excitation pulse in each repetition is less than 8% of an average value of said sum over all of said repetitions of said repetition sequence.

### Claim 12

A method for magnetic resonance (MR) fingerprinting, comprising:
with a computer, operating an MR data acquisition scanner to execute a repetition sequence in a plurality of repetitions and, in each repetition, radiating a first radio-frequency (RF) excitation pulse into an examination subject, situated in the scanner, that excites a magnetization of nuclear spins in a first slice of the subject, and acquiring first MR data resulting from said first RF excitation pulse;
with said computer, operating said scanner, in each repetition, to also radiate a second RF excitation pulse that excites a magnetization of nuclear spins in a second slice of the examination subject, that is different from said first slice, and acquiring second MR data resulting from said second RF excitation pulse;
with said computer, operating said scanner to radiate said first RF excitation pulse and said second RF excitation pulse in the respective repetitions so as to be radiated at least partly in parallel in time and, in at least some of said repetitions, radiating said first RF excitation pulse with flip angle that differs from a flip angle of said second RF excitation pulse;
in said computer, implementing a first optimization of the flip angles of the first RF excitation pulses dependent on at least one optimization criterion for said first RF excitation pulses, and implementing a second optimization of the flip angles of the second RF excitation pulses dependent on an optimization criterion for said second RF excitation pulses;
in said computer, determining a first MR image of the first slice based on a fingerprinting directory and said first MR data, and determining a second MR image of the second slice based on said fingerprinting directory and said second MR data; and
making the first MR image and the second MR image available in electronic form from said computer as respective data files.

### Claim 13 (depends on 12)

A method as claimed in claim 12 comprising selecting at least one of the optimization criterion for said first RF excitation pulses and the optimization criterion for said second optimization pulses from the group consisting of a maximum RF energy of the repetition sequence, a scattering of local maxima of a sum of the RF energy of the first RF excitation pulses and RF energy of said second RF excitation pulses in each repetition over said repetition sequence, a difference between the respective flip angles of the first RF excitation pulses and the flip angles of the second RF excitation pulses for different repetitions, and a signal-to-noise ratio of said first MR data and said second MR data.

### Claim 14 (depends on 12)

A method as claimed in claim 12 comprising, with said computer, operating said scanner to vary the respective flip angles of said first RF excitation pulses in different repetitions, and to vary the respective flip angles of said RF excitation pulse in different repetitions.

### Claim 15 (depends on 12)

A method as claimed in claim 12 comprising, with said computer, operating said scanner to give the flip angle of the first RF excitation pulses in respective repetitions a dependency on the respective repetitions that is complementary to dependency of the respective flip angles of second RF excitation pulses on said respective repetitions.

### Claim 16 (depends on 12)

A method as claimed in claim 12 comprising, with said computer, operating said scanner to give the flip angle of the first RF excitation pulses in respective repetitions a dependency on the respective repetitions that correspond to dependency of the respective flip angles of second RF excitation pulses on said respective repetitions.

### Claim 17 (depends on 16)

A method as claimed in claim 16 wherein the dependency of the respective flip angles of the first RF excitation pulses on the respective repetitions is described by a first function, and wherein the dependency of the flip angles of the second radio-frequency excitation pulses in the respective repetitions is described by a second function, wherein said first function corresponds to said second function.

### Claim 18 (depends on 17)

A method as claimed in claim 17 wherein said first function is equal to said second function multiplied by a scaling factor that is not equal to one.

### Claim 19 (depends on 17)

A method as claimed in claim 17 wherein said first function is equal to said second function by displaced by at least one repetition.

### Claim 20 (depends on 17)

A method as claimed in claim 17 wherein said first and second functions have oscillations with a periodicity that is dependent on the respective repetitions.

### Claim 21 (depends on 12)

A method as claimed in claim 12 wherein a scattering of the sum of the RF energy of the first RF excitation pulse and the RF energy of the second RF excitation pulse in each repetition is less than 80% of an average value of said sum over all of said repetitions of said repetition sequence.

### Claim 22 (depends on 12)

A method as claimed in claim 12 wherein said scattering of the local maxima of the sum of RF energy of said first RF excitation pulse and said second RF excitation pulse in each repetition is no larger than 50% of said average value of said sum over all of said repetitions of said repetition sequence.

### Claim 23

A magnetic resonance (MR) apparatus comprising:
an MR data acquisition scanner;
a computer configured to operate said MR data acquisition scanner to execute a repetition sequence in a plurality of repetitions and, in each repetition, to radiate a first radio-frequency (RF) excitation pulse into an examination subject, situated in the scanner, that excites a magnetization of nuclear spins in a first slice of the subject, and to acquire first MR data resulting from said first RF excitation pulse;
said computer being configured to operate said scanner, in each repetition, to also radiate a second RF excitation pulse that excites a magnetization of nuclear spins in a second slice of the examination subject, that is different from said first slice, and to acquire second MR data resulting from said second RF excitation pulse;
said computer being configured to operate said scanner to radiate said first RF excitation pulse and said second RF excitation pulse in the respective repetitions so as to be radiated at least partly in parallel in time and, in at least some of said repetitions, to radiate said first RF excitation pulse with flip angle that differs from a flip angle of said second RF excitation pulse;
said computer being configured to operate said scanner to execute said repetitions of said repetition sequence with a scattering of local maxima of a sum of RF energy of said first RF excitation pulse and said second RF excitation pulse in each repetition, to be less than 80% of an average value of said sum over all of said repetitions of said repetition sequence;
said computer being configured to determine a first MR image of the first slice based on a fingerprinting directory and said first MR data, and to determine a second MR image of the second slice based on said fingerprinting directory and said second MR data; and
said computer being configured to make the first MR image and the second MR image available in electronic form from said computer as respective data files.

### Claim 24

A magnetic resonance (MR) apparatus comprising:
an MR data acquisition scanner;
a computer being configured to operate said MR data acquisition scanner to execute a repetition sequence in a plurality of repetitions and, in each repetition, to radiate a first radio-frequency (RF) excitation pulse into an examination subject, situated in the scanner, that excites a magnetization of nuclear spins in a first slice of the subject, and to acquire first MR data resulting from said first RF excitation pulse;
said computer being configured to operate said scanner, in each repetition, to also radiate a second RF excitation pulse that excites a magnetization of nuclear spins in a second slice of the examination subject, that is different from said first slice, and to acquire second MR data resulting from said second RF excitation pulse;
said computer being configured to operate said scanner to radiate said first RF excitation pulse and said second RF excitation pulse in the respective repetitions so as to be radiated at least partly in parallel in time and, in at least some of said repetitions, to radiate said first RF excitation pulse with flip angle that differs from a flip angle of said second RF excitation pulse;
said computer being configured to implement a first optimization of the flip angles of the first RF excitation pulses dependent on at least one optimization criterion for said first RF excitation pulses, and to implement a second optimization of the flip angles of the second RF excitation pulses dependent on an optimization criterion for said second RF excitation pulses;
said computer being configured to determine a first MR image of the first slice based on a fingerprinting directory and said first MR data, and determining a second MR image of the second slice based on said fingerprinting directory and said second MR data; and
said computer being configured to make the first MR image and the second MR image available in electronic form from said computer as respective data files.