# US 10,309,977 B2 · Device for detecting and/or analyzing bio-chip

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- Number: US 10,309,977 B2
- Document ID: US10309977B2
- Status: Granted
- Kind: B2
- Application number: 15/511,216
- Filed: 2015-09-25
- Published: 2017-10-05
- Granted: 2019-06-04
- Earliest claimed: 2014-09-28
- Assignees: CapitalBio Corporation
- Applicants: CapitalBio Corporation
- Inventors: Yuan Xue; Guanbin Zhang; Cheng Chen; Kaijun Zhao; Yu Dong; Jing Cheng
- Web page: https://patentgrep.com/patent/US10309977B2

## CPC

- G01N 35/00069: {whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk}
- G01N 21/15: Preventing contamination of the components of the optical system or obstruction of the light path
- G01N 21/251: {Colorimeters; Construction thereof}
- G01N 21/78: producing a change of colour
- B01L 3/5027: {by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip}
- B01L 2200/10: Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
- G01N 15/1436: {the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell}
- G01N 21/88: Investigating the presence of flaws or contamination
- G01N 35/025: {having a carousel or turntable for reaction cells or cuvettes}
- G01N 2035/00158: {Elements containing microarrays, i.e. "biochip"}
- G01N 2035/00306: {Housings, cabinets, control panels (details)}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

## Abstract

In some aspects, the present disclosure provides a biochip detecting device that comprises a first shell (2) connect to a second shell (1), and a rotatable support frame (5) of biochip possessing a detecting zone that holds one or more biochips, and a detector (7).

## Claims

### Claim 1

A device, comprising:
a first shell;
a second shell connected to the first shell, wherein the first and second shells are configured to engage with each other to form a substantially closed carton;
a rotatable support frame located between the first and second shells, wherein the rotatable support frame comprises a detecting zone configured to hold an object to be detected and/or analyzed; and
a detector;
further comprising a light source, wherein, the light source is disposed on the first shell or the second shell, and wherein the light source and the detector are disposed on opposite sides of the rotatable support frame.

### Claim 2 (depends on 1)

The device of claim 1, wherein the first shell comprises a holding cavity.

### Claim 3 (depends on 2)

The device of claim 2, wherein the holding cavity comprises an upper plate facing the second shell.

### Claim 4 (depends on 3)

The device of claim 3, wherein the rotatable support frame is disposed on the upper plate of the holding cavity of the first shell.

### Claim 5 (depends on 3)

The device of claim 3, wherein the upper plate comprises a through-hole that is capable of aligning with the detecting zone of the rotatable support frame.

### Claim 6 (depends on 1)

The device of claim 1, wherein the object comprises a chip such as a biochip.

### Claim 7 (depends on 1)

The device of claim 1, wherein the device is for detecting and/or analyzing a chip such as a biochip.

### Claim 8 (depends on 1)

The device of claim 1, wherein the rotatable support frame comprises a plurality of detecting zones each of which is capable of holding an object to be detected and/or analyzed.

### Claim 9 (depends on 1)

The device of claim 1, further comprising an output unit for outputting a result of the detection and/or analysis.

### Claim 10 (depends on 9)

The device of claim 9, wherein the output unit is disposed on the first shell, such as in a holding cavity of the first shell.

### Claim 11 (depends on 1)

The device of claim 1, wherein the light source is disposed on the second shell.

### Claim 12 (depends on 11)

The device of claim 11, wherein the detector is disposed in the holding cavity of the first shell and aligns with the through-hole.

### Claim 13 (depends on 12)

The device of claim 12, wherein the detector, the light source, the detecting zone, and the through-hole are collinear when the first and second shells engage each other to form a substantially closed carton.

### Claim 14 (depends on 1)

The device of claim 1, further comprising one or more macro lenses.

### Claim 15 (depends on 1)

The device of claim 1, further comprising one or more macro lenses.

### Claim 16 (depends on 15)

The device of claim 15, wherein the one or more macro lenses are disposed in the holding cavity of the first shell.

### Claim 17 (depends on 15)

The device of claim 15, wherein the one or more macro lenses are disposed between the through-hole and the detector.

### Claim 18 (depends on 15)

The device of claim 15, wherein the one or more macro lenses are collinear with the through-hole and the detector.

### Claim 19 (depends on 15)

The device of claim 15, further comprising one or more optical filters disposed between the through-hole and the one or more macro lenses.

### Claim 20 (depends on 1)

The device of claim 1, further comprising a rotary shaft disposed on or connected to the upper plate of the holding cavity of the first shell.

### Claim 21 (depends on 20)

The device of claim 20, wherein the rotary shaft is disposed on or connected to the support frame.

### Claim 22 (depends on 21)

The device of claim 21, further comprising a driving unit that is capable of rotating the rotary shaft.

### Claim 23 (depends on 22)

The device of claim 22, wherein the driving unit is disposed in the holding cavity.

### Claim 24

A device, comprising:
a first shell;
a second shell connected to the first shell, wherein the first and second shells are capable of engaging each other to form a substantially closed carton;
a rotatable support frame located between the first and second shells, wherein the rotatable support frame comprises a detecting zone that is capable of holding an object to be detected and/or analyzed;
a detector;
a light source;
a rotary shaft disposed on or connected to the upper plate of the holding cavity of the first shell, wherein the rotary shaft is disposed on or connected to the support frame;
a driving unit that is capable of rotating the rotary shaft, wherein the driving unit is disposed in the holding cavity;
a rotor connected to the rotary shaft, which rotor comprises a plurality of protuberances around the periphery of the rotor;
a pushrod that is capable of applying a force to drive the rotation of the rotor, which pushrod is configured to fit the protuberances of the rotor and protrude from the holding cavity;
a biasing member connected to the pushrod that is capable of resetting the position of the pushrod to release the rotor;
a rotor securing lever that is connected to the lower surface of the upper plate of the holding cavity, which rotor securing lever comprises a neck that is capable of fitting the protuberances of the rotor to make the rotor spin in a single direction; and
a spring connected to the rotor securing lever at one end and to the lower surface of the upper plate of the holding cavity at the other end.

### Claim 25 (depends on 24)

The device of claim 24, wherein the pushrod comprises:
a positioning rod disposed on the lower surface of the upper plate of the holding cavity;
a guiding rod comprising a sharp-edged tip capable of fittingly engage the protuberances of the rotor, and a chute capable of fittingly engage the positioning rod, which guiding rod is connected to the biasing member; and
a button connected to the guiding rod at one end, with the other end protruding from the holding cavity.

### Claim 26 (depends on 24)

The device of claim 24, wherein the driving unit further comprises a damper connected to the rotor.

### Claim 27 (depends on 1)

The device of claim 1, further comprising a light source and a shielding plate disposed at the periphery of the light source.

### Claim 28 (depends on 1)

A method of detecting and/or analyzing an object, comprising placing the object in the detecting zone of the device of claim 1.