# US 10,308,986 B2 · Cancer diagnosis, treatment selection and treatment

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- Number: US 10,308,986 B2
- Document ID: US10308986B2
- Status: Granted
- Kind: B2
- Application number: 14/774,772
- Filed: 2014-03-13
- Published: 2016-05-05
- Granted: 2019-06-04
- Earliest claimed: 2013-03-14
- Assignees: Children's Medical Center Corporation; The Brigham and Women's Hospital, Inc.; Dana-Farber Cancer Institute, Inc.; The Technical University of Denmark, Kgs
- Applicants: Children's Medical Center Corporation; The Brigham and Women's Hospital, Inc.; Dana-Farber Cancer Institute, Inc.; The Technical University of Denmark
- Inventors: Zoltan I. Szallasi; Andrea L. Richardson; Nicolai J. Birkbak; Zhigang Wang
- Web page: https://patentgrep.com/patent/US10308986B2

## CPC

- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)}
- A61K 33/243: Platinum; Compounds thereof
- G01N 33/57515: of the breast
- C12Q 2600/106: Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
- C12Q 2600/156: Polymorphic or mutational markers
- C12Q 2600/158: Expression markers
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention provides assays, methods and systems for selecting an effective therapy for a subset of cancer patients having cancer cells with increased expression of BML and FANCI genes and/or having copy number increase in chromosome location 15q26 in the cancer cells and for treatment of such patients with the effective therapy of cancer patients based on the personalized cancer cell expression profile.

## Claims

### Claim 1

A method for treating cancer having increased expression of BLM and FANCI of at least two-fold compared to BRCA1 expression in a human subject in need thereof, said method comprising the step of administering a platinum-comprising cancer chemotherapy to the human subject.

### Claim 2

A method of treating cancer having cancer cells with a chromosome 15q26 copy number gain compared to the cancer cells' chromosome 15centromere copy number in a human subject in need thereof, said method comprising the step of administering a platinum-comprising cancer chemotherapy to the human subject.

### Claim 3 (depends on 2)

The method of claim 2, wherein the cancer is selected from breast cancer, ovarian cancer and lung cancer.

### Claim 4 (depends on 2)

The method of claim 2, wherein the subject's cancer is known to not express a detectable quantity of ER, PgR, and HER2 receptor.