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US 10,308,956 B2Granted
HVT-vectored ND-IBD vaccine
AssigneeIntervet Inc.
InventorsIwan Verstegen, Paulus Jacobus Antonius Sondermeijer, Paul Vermeij
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Abstract
The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene from NDV to a target animal. The recombinant HVT can be used in a vaccine for poultry, which displayed good viral vector replication, effective expression of the NDV F- and IBDV VP2 genes, improved immunoprotection against ND and IBD, and improved genetic stability over prior art constructs.
Claims18
A recombinant DNA expression cassette comprising in the 5′ to 3′ direction and in the following order:
- a. a murine cytomegalovirus immediate early 1 gene (mCMV-IE1) promoter,
- b. an infectious bursal disease virus (IBDV) viral protein 2 (VP2) gene,
- c. a transcription terminator,
- d. a human cytomegalovirus immediate early 1 gene (hCMV-IE1) promoter, and
- e. a Newcastle disease virus (NDV) fusion (F) protein gene.
2 more elements
Dependencies are inferred from the claim text.