# US 10,308,933 B2 · Methods for diagnosing and treating learning or mental disorders

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- Number: US 10,308,933 B2
- Document ID: US10308933B2
- Status: Granted
- Kind: B2
- Application number: 14/984,045
- Filed: 2015-12-30
- Published: 2016-04-21
- Granted: 2019-06-04
- Earliest claimed: 2012-02-02
- Assignees: St. Jude Children's Research Hospital
- Applicants: St. Jude Children's Research Hospital
- Inventors: Stanislav S. Zakharenko; Laurie R. Earls
- Web page: https://patentgrep.com/patent/US10308933B2

## CPC

- C12N 15/113: Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; {Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing (when used in plants C12N15/8218)}
- A61K 31/7105: Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
- C12Q 1/6883: for diseases caused by alterations of genetic material
- C12N 2310/141: MicroRNAs, miRNAs
- C12N 2320/30: Special therapeutic applications
- C12Q 2600/118: Prognosis of disease development
- C12Q 2600/158: Expression markers
- C12Q 2600/178: miRNA, siRNA or ncRNA
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

## Abstract

The present invention embraces methods for the diagnosis and treatment of learning or mental disorders such as schizophrenia using miR-25, miR-98, or miR-185.

## Claims

### Claim 1

A method for improving hippocampal synaptic plasticity comprising administering to a subject exhibiting an age-dependent alteration in synaptic plasticity an effective amount of microRNA (miR)-98 in combination with an antipsychotic, psychostimulant or Alzheimer's disease therapeutic thereby improving the subject's hippocampal synaptic plasticity.

### Claim 2

A method for treating a mental disorder comprising administering to a subject having a 22q11 deletion syndrome, schizophrenia, or autism spectrum disorder an effective amount of microRNA (miR) -98 in combination with an antipsychotic, psychostimulant or Alzheimer's disease therapeutic thereby treating the subject's mental disorder.

### Claim 3

A method for improving hippocampal synaptic plasticity comprising administering to a subject exhibiting an age-dependent alteration in synaptic plasticity an effective amount of microRNA (miR)-25 in combination with an antipsychotic, psychostimulant or Alzheimer's disease therapeutic thereby improving the subject's hippocampal synaptic plasticity.

### Claim 4

A method for treating a mental disorder comprising administering to a subject having 22q11 deletion syndrome, schizophrenia, or autism spectrum disorder an effective amount of microRNA (miR)-25 in combination with an antipsychotic, psychostimulant or Alzheimer's disease therapeutic thereby treating the subject's mental disorder.