# US 10,308,745 B2 · Copolymer and medical device, separation membrane module for medical use, and blood purifier including the same

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- Number: US 10,308,745 B2
- Document ID: US10308745B2
- Status: Granted
- Kind: B2
- Application number: 15/556,002
- Filed: 2016-03-15
- Published: 2018-06-14
- Granted: 2019-06-04
- Earliest claimed: 2015-03-31
- Assignees: Toray Industries, Inc.
- Applicants: Toray Industries, Inc.
- Inventors: Suguru Ushiro; Hiroshi Takahashi; Yoshiyuki Ueno
- Web page: https://patentgrep.com/patent/US10308745B2

## CPC

- C08F 226/10: N-Vinyl-pyrrolidone
- A61K 35/16: Blood plasma; Blood serum (umbilical cord blood A61K35/51)
- A61L 33/064: {obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L33/062 takes precedence)}
- A61M 1/16: with membranes
- A61M 1/34: Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- B01D 67/0088: {Physical treatment with compounds, e.g. swelling, coating or impregnation}
- B01D 67/009: {with wave-energy, particle-radiation or plasma}
- B01D 69/06: Flat membranes
- B01D 69/08: Hollow fibre membranes (manufacture of hollow fibres D01D5/24, D01F1/08)
- B01D 71/381: {Polyvinylalcohol}
- B01D 71/441: {Polyvinylpyrrolidone}
- B01D 71/68: Polysulfones; Polyethersulfones
- B01D 71/76: Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74 (rubbers in general B01D71/24)
- C08F 218/10: of monocarboxylic acids containing three or more carbon atoms
- C09D 139/06: Homopolymers or copolymers of N-vinyl-pyrrolidones
- A61M 2205/7563: with means preventing clogging of filters
- C08F 226/06: by a heterocyclic ring containing nitrogen
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D)

## Abstract

A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7.

## Claims

### Claim 1

A copolymer comprising a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit includes at least one vinyl carboxylate unit, and the vinyl carboxylate unit has 2 or more and 7 or less carbon atoms at a side chain terminal thereof, wherein the hydrophilic unit includes a vinylpyrrolidone unit.

### Claim 2 (depends on 1)

The copolymer according to claim 1, having a number average molecular weight of 2,000 or more.

### Claim 3 (depends on 1)

The copolymer according to claim 1, wherein the hydrophilic unit has a mole fraction to the whole copolymer of 30% or more and 90% or less.

### Claim 4 (depends on 1)

The copolymer according to claim 1, wherein the hydrophilic unit and the hydrophobic unit are arranged randomly or alternately.

### Claim 5

A medical device comprising a copolymer comprising a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit includes at least one vinyl carboxylate unit, and the vinyl carboxylate unit has 2 or more and 7 or less carbon atoms at a side chain terminal thereof, comprising the copolymer introduced onto at least a part of a surface thereof that is in contact with a biological component.

### Claim 6

A separation membrane module for medical use, comprising a separation membrane including a copolymer comprising a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit includes at least one vinyl carboxylate unit, and the vinyl carboxylate unit has 2 or more and 7 or less carbon atoms at a side chain terminal thereof.

### Claim 7 (depends on 6)

The separation membrane module according to claim 6, wherein the separation membrane includes a polysulfone-based polymer as a main raw material.

### Claim 8

A blood purifier comprising a copolymer comprising a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit includes at least one vinyl carboxylate unit, and the vinyl carboxylate unit has 2 or more and 7 or less carbon atoms at a side chain terminal thereof.

### Claim 9 (depends on 8)

The blood purifier according to claim 8, which is a continuous renal replacement.

### Claim 10 (depends on 8)

The blood purifier according to claim 8, comprising the copolymer introduced onto at least a part of a surface thereof that is in contact with blood or a biological component.

### Claim 11 (depends on 9)

The blood purifier according to claim 9, comprising the copolymer introduced onto at least a part of a surface thereof that is in contact with blood or a biological component.

### Claim 12 (depends on 2)

The copolymer according to claim 2, wherein the hydrophilic unit has a mole fraction to the whole copolymer of 30% or more and 90% or less.

### Claim 13 (depends on 2)

The copolymer according to claim 2, wherein the hydrophilic unit and the hydrophobic unit are arranged randomly or alternately.

### Claim 14 (depends on 3)

The copolymer according to claim 3, wherein the hydrophilic unit and the hydrophobic unit are arranged randomly or alternately.