# US 10,308,698 B2 · Therapeutic targeting of SET1B/compass pathway for treating cancers

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,308,698 B2
- Document ID: US10308698B2
- Status: Granted
- Kind: B2
- Application number: 15/645,282
- Filed: 2017-07-10
- Published: 2018-01-11
- Granted: 2019-06-04
- Earliest claimed: 2016-07-08
- Assignees: Northwestern University
- Applicants: Northwestern University
- Inventors: Ali Shilatifard; Lu Wang
- Web page: https://patentgrep.com/patent/US10308698B2

## CPC

- C07K 14/5759: {Products of obesity genes, e.g. leptin, obese (OB), tub, fat}
- A61K 38/2264: {Obesity-gene products, e.g. leptin}
- C07K 7/06: having 5 to 11 amino acids
- C07K 14/4702: {Regulators; Modulating activity}
- C07K 16/3015: {Breast}
- C12N 15/1137: {against enzymes (viral enzymes C12N15/1131; receptors C12N15/1138)}
- C12Q 1/6886: for cancer (immunoassay for cancer G01N33/575)
- C12Y 201/01043: Histone-lysine N-methyltransferase (2.1.1.43)
- C12N 2310/14: interfering nucleic acids [NA]
- C12N 2310/20: involving clustered regularly interspaced short palindromic repeats [CRISPR]
- C12N 2310/531: Stem-loop; Hairpin
- C12Q 2600/156: Polymorphic or mutational markers
- C12Q 2600/158: Expression markers
- C12Q 2600/178: miRNA, siRNA or ncRNA
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Y: ENZYMES

## Abstract

Disclosed are methods for treating Set1/COMPASS-associated cancers characterized by expression of Set1B/COMPASS. The methods typically include administering a therapeutic amount of an inhibitor of the Set1B/COMPASS pathway and/or an agonist for a target that is negatively regulated by the Set1B/COMPASS pathway.

## Claims

### Claim 1

A method for inhibiting tumor growth of a cancer characterized by expression of Set1B/COMPASS in a subject in need thereof, the method comprising administering to the subject a therapeutic amount of a compound having a formula:
wherein the cancer is triple negative breast cancer (TNBC).

### Claim 2

A method for inhibiting tumor growth of triple negative breast cancer (TNBC) in a subject in need thereof, the method comprising administering to the subject a therapeutic amount of a compound having a formula: