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US 10,308,687 B2Granted
Cell-penetrating compstatin analogs and uses thereof
AssigneeApellis Pharmaceuticals, Inc.
InventorsCedric Francois, Pascal Deschatelets, Monica Gerber
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Abstract
In some aspects, the present invention cell-penetrating compstatin analog and compositions comprising cell-penetrating compstatin analog. In some aspects, the invention further provides methods of using cell-penetrating compstatin analogs treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ, to inhibit production or release of biologically active C3 cleavage products.
Claims13
A compound comprising:
- (i) a compstatin analog moiety comprising a peptide comprising an amino acid sequence of one of SEQ ID NOs:
- 3-6 and 9-36;
- and
- (ii) a cell penetrating moiety (CPM) comprising a cell penetrating peptide comprising an amino acid sequence of one of SEQ ID NOs:
- 77-136,
- wherein the compstatin analog moiety is covalently linked to the CPM.
3 more elements
A composition comprising (a) an isolated cell;
- and (b) a compound comprising:
- (i) a compstatin analog moiety comprising a peptide comprising an amino acid sequence of one of SEQ ID NOs:
- 3-6 and 9-36;
- and
- (ii) a cell penetrating moiety (CPM) comprising a cell penetrating peptide comprising an amino acid sequence of one of SEQ ID NOs:
- 77-136,
- wherein the compstatin analog moiety is covalently linked to the CPM.
4 more elements
Dependencies are inferred from the claim text.