Back to results
US 10,308,676 B2Granted
Methods of making onapristone intermediates
AssigneeContext Biopharma Inc.
InventorsUlf Tilstam, Stefan Proniuk, Holger Bindernagel, Silvia Werner, Holger Rauter
Life of this patent
Estimating the term…
Abstract
Methods and systems for making intermediates in the synthesis of onapristone are provided. Aspects include the photoconversion of onapristone synthesis intermediates using a narrow band frequency light source.
Claims14
A method of making the compound of Formula II
- comprising irradiating the compound of Formula I
- with narrow band frequency light from a lamp selected from the group consisting of excimer DBD light source and LED at a wavelength from about 295 nm to about 320 nm;
- wherein taken together the two instances of X combine to form a spirocyclic ring of the formula of —OCH2CH2O— or —OCH2C(Me)2CH2O—.
A method of making Steroid 2:
- comprising irradiating the compound of Formula I
- with narrow band frequency light from a lamp selected from the group consisting of excimer DBD light source and LED, at a wavelength from about 295 nm to about 320 nm.
A method of making the compound of Formula II
- comprising irradiating the compound of Formula I
- with narrow band frequency light from a lamp selected from the group consisting of excimer DBD light source and LED at a wavelength from about 295 nm to about 320 nm;
- wherein X is selected from the group consisting of OMe, OEt, and OPr.
Dependencies are inferred from the claim text.