# US 10,308,664 B2 · [18F] fluoride cryptate complexes for radiolabeling fluorinations

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- Number: US 10,308,664 B2
- Document ID: US10308664B2
- Status: Granted
- Kind: B2
- Application number: 13/589,155
- Filed: 2012-08-19
- Published: 2014-02-20
- Granted: 2019-06-04
- Earliest claimed: 2012-08-19
- Applicants: Yousry M. A. Naguib; Ashraf Naguib; Ahmed Naguib
- Inventors: Yousry M. A. Naguib; Ashraf Naguib; Ahmed Naguib
- Web page: https://patentgrep.com/patent/US10308664B2

## CPC

- C07D 498/08: Bridged systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention claims complexing [18F] fluoride anion with diaryl and aryl fused-[2.2.2]cryptand to form [18F] fluoride diaryl and aryl fused-cryptate complexes suitable for performing radio-labeling reactions to generate [18F] fluorinated species.

## Claims

### Claim 1

A method of complexing [18F]fluoride anion comprising combining [18F]fluoride anion with a diaryl and aryl fused [2.2.2]cryptand and alkali metal salt wherein the cryptand is selected from the group consisting of
and dinaphtho[2.2.2]cryptand.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the [18F]fluoride cryptate complex is then used to radiolabel [18F]fluorinated species.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the radiolabeled [18F]fluorinated species is viewed by an imaging technique.

### Claim 4 (depends on 3)

The method according to claim 3, wherein the imaging technique is a PET scanner.