# US 10,308,642 B2 · Anti-hepatitis B virus agent

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- Number: US 10,308,642 B2
- Document ID: US10308642B2
- Status: Granted
- Kind: B2
- Application number: 15/765,011
- Filed: 2016-10-05
- Published: 2018-10-11
- Granted: 2019-06-04
- Earliest claimed: 2015-10-05
- Assignees: FUJIFILM Toyama Chemical Co., Ltd.; Public University Corporation Nagoya City University
- Applicants: FUJIFILM Toyama Chemical Co., Ltd.; Public University Corporation Nagoya City University
- Inventors: Kazuki Shimane; Yasuhito Tanaka
- Web page: https://patentgrep.com/patent/US10308642B2

## CPC

- C07D 409/04: directly linked by a ring-member-to-ring-member bond
- A61K 31/4422: 1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A61K 31/443: containing a five-membered ring with oxygen as a ring hetero atom
- A61K 31/4436: containing a heterocyclic ring having sulfur as a ring hetero atom
- A61K 31/4439: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465)
- A61P 31/20: for DNA viruses
- C07D 213/80: in position 3
- C07D 405/10: linked by a carbon chain containing aromatic rings
- C07D 409/10: linked by a carbon chain containing aromatic rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

An anti-hepatitis B virus agent comprising a compound represented by general formula [1], wherein R1 represents an aryl group, which may be substituted, or the like; R2 represents an aryl group, which may be substituted, or the like; and R3 represents a hydrogen atom or the like; or a salt thereof.

## Claims

### Claim 1

A method of treating hepatitis B virus, the method comprising administering an anti-hepatitis B virus agent to a patient in need thereof, the anti-hepatitis B virus agent comprising a compound represented by general formula [1]:
wherein R1 represents an aryl group which may be substituted or a heterocyclic group which may be substituted;
R2 represents a C3-8 cycloalkyl group which may be substituted, an aryl group which may be substituted, or a heterocyclic group which may be substituted; and
R3 represents a hydrogen atom or a carboxyl protecting group, or a salt thereof.

### Claim 2 (depends on 1)

The method according to claim 1, wherein R1 represents an aryl group which may be substituted.

### Claim 3 (depends on 1)

The method according to claim 1, wherein R1 represents a phenyl group which may be substituted.

### Claim 4 (depends on 1)

The method according to claim 1, wherein R1 represents a heterocyclic group which may be substituted.

### Claim 5 (depends on 1)

The method according to claim 1, wherein R1 represents a bicyclic heterocyclic group which may be substituted.

### Claim 6 (depends on 1)

The method according to claim 1, wherein R2 represents an aryl group which may be substituted.

### Claim 7 (depends on 1)

The method according to claim 1, wherein R2 represents a phenyl group which may be substituted.

### Claim 8 (depends on 1)

The method according to claim 1, wherein R2 represents a heterocyclic group which may be substituted.

### Claim 9 (depends on 1)

The method according to claim 1, wherein R2 represents a monocyclic heterocyclic group which may be substituted.