# US 10,308,639 B2 · Phosphatidylinositol 3-kinase inhibitors

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- Number: US 10,308,639 B2
- Document ID: US10308639B2
- Status: Granted
- Kind: B2
- Application number: 14/735,924
- Filed: 2015-06-10
- Published: 2015-12-17
- Granted: 2019-06-04
- Earliest claimed: 2014-06-13
- Assignees: Gilead Sciences, Inc.
- Applicants: Gilead Sciences, Inc.
- Inventors: Jerry Evarts; Joshua Kaplan; Leena Patel; Stephane Perreault; Barton W. Phillips; Gary Phillips; Jennifer A. Treiberg; Suet Chung Yeung
- Web page: https://patentgrep.com/patent/US10308639B2

## CPC

- C07D 403/14: containing three or more hetero rings
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/06: Antiasthmatics
- A61P 13/00: Drugs for disorders of the urinary system
- A61P 13/12: of the kidneys
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/06: Antipsoriatics
- A61P 17/14: for baldness or alopecia
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/02: Immunomodulators
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 471/04: Ortho-condensed systems
- C07D 473/34: attached in position 6, e.g. adenine
- C07D 487/04: Ortho-condensed systems
- C07D 491/04: Ortho-condensed systems
- C07D 491/048: the oxygen-containing ring being five-membered
- C07D 495/04: Ortho-condensed systems
- C07D 498/04: Ortho-condensed systems
- C07D 513/04: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein X, Y, Z, n, m′, A′, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

## Claims

### Claim 1

A compound having the structure of formula (I):
wherein:
X, Y and Z are independently selected from C(R′) and N, wherein at least one of X, Y, and Z is C(R′);
n is 0, 1, 2, 3, or 4;
m′ is 0 or 1;
A is a single bond or C(O);
each R′ is independently selected from hydrogen, halo, optionally substituted alkyl, optionally substituted haloalkyl, and optionally substituted cycloalkyl;
each R1 is independently selected from halo, cyano, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkoxy, hydroxy, optionally substituted C3-8 cycloalkyl, and optionally substituted sulfonyl;
each R2 is independently selected from halo, optionally substituted C1-6 alkyl, optionally substituted C1-6 haloalkyl, and optionally substituted C3-8 cycloalkyl;
R3 is hydrogen, optionally substituted C1-6 alkyl, optionally substituted C3-8 cycloalkyl, or optionally substituted C6-10 aryl;
R4 is a six- to twelve-membered heteroaryl selected from the group consisting of pyrimidinyl, pyrazinyl, pyridazinyl, thiazolopyrimidinyl, pyridopyrimidinyl, thienopyrimidinyl, pyrrolopyrimidinyl, furopyrimidinyl, and imidazotriazinyl, wherein the heteroaryl is optionally substituted with one, two, or three members independently selected from halo, cyano, —NH2, optionally substituted C1-6 alkyl, and optionally substituted C2-6 alkynyl; and
R5 is hydrogen or optionally substituted C1-6 alkyl;
or a pharmaceutically acceptable salt, isomer, or a mixture thereof.

### Claim 2 (depends on 1)

The compound of claim 1, wherein
A is a single bond;
each R′ is independently selected from hydrogen, halo, C1-4 alkyl, C1-4 haloalkyl, and C3-6 cycloalkyl, wherein the alkyl moiety is optionally substituted with C1-4 alkoxy;
each R1 is independently selected from halo, cyano, C1-4 alkyl, C1-4 haloalkyl, and —SO2C1-4 alkyl;
each R2 is independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, and C3-6 cycloalkyl, wherein the alkyl moiety is optionally substituted with C1-4 alkoxy;
R3 is hydrogen, C1-4 alkyl, C3-6 cycloalkyl, or C6-10 aryl; wherein the alkyl moiety is optionally substituted with hydroxyl or C1-4 alkoxy, wherein C1-4 alkoxy is optionally substituted with C6-10 aryl;
R4 is a six- to twelve-membered heteroaryl selected from the group consisting of pyrimidinyl, pyrazinyl, pyridazinyl, thiazolopyrimidinyl, pyridopyrimidinyl, thienopyrimidinyl, pyrrolopyrimidinyl, furopyrimidinyl, and imidazotriazinyl, wherein the heteroaryl is optionally substituted with one, two, or three members independently selected from halo, cyano, —NH2, C2-4 alkynyl, C1-4 haloalkyl, and C1-4 alkyl, wherein the C2-4 alkynyl moiety is optionally substituted with C6-10 aryl or C3-8 heteroaryl, wherein each of the C6-10 aryl and C3-8 heteroaryl moieties is optionally substituted with one or two members independently selected from halo and C1-6 haloalkyl; and
R5 is hydrogen or C1-4 alkyl;
or a pharmaceutically acceptable salt, isomer, or a mixture thereof.

### Claim 3 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, wherein each R1 is independently selected from fluoro, chloro, bromo, iodo, methyl, ethyl, propyl, butyl, fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, difluoroethyl, trifluoroethyl, cyano, methylsulfonyl, and ethylsulfonyl.

### Claim 4 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, wherein each R2 is independently selected from fluoro, chloro, bromo, iodo, methyl, ethyl, propyl, butyl, fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, difluoroethyl, trifluoroethyl, methoxymethyl, methoxyethyl, ethoxymethyl, methoxypropyl, ethoxyethyl, ethoxypropyl, cyclopropyl, and cyclobutyl.

### Claim 5 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, wherein R3 is selected from methyl, ethyl, propyl, cyclopropyl, cyclobutyl, phenyl, benzyloxymethyl, benzyloxyethyl, benzyloxypropyl, —CH2OH, —C2H4OH, and —C3H6OH.

### Claim 6 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, wherein R5 is selected from hydrogen, methyl, ethyl, and propyl.

### Claim 7 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, wherein R4 is pyrimidinyl, pyrazinyl, or pyridazinyl, each of which is optionally substituted with two or three members independently selected from the group consisting of halo, cyano, —NH2, C1-4 alkyl, and C2-4 alkynyl, wherein the C2-4 alkynyl moiety is substituted with C6-10 aryl or C3-8 heteroaryl, each of C6-10 aryl or C3-8 heteroaryl is optionally substituted with one or two members independently selected from halo and C1-4 haloalkyl.

### Claim 8 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, wherein R4 is thiazolopyrimidinyl, pyridopyrimidinyl, thienopyrimidinyl, pyrrolopyrimidinyl, furopyrimidinyl, or imidazotriazinyl, each of which is optionally substituted with one, two, or three members independently selected from the group consisting of halo, cyano, —NH2, and C1-4 alkyl.

### Claim 9 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, wherein the heteroaryl of R4 is optionally substituted with one, two, or three members independently selected from the group consisting of bromo, chloro, fluoro, iodo, cyano, —NH2, methyl, ethyl, propyl, butyl, and C2-4 alkynyl, wherein the C2-4 alkynyl moiety is optionally substituted with C6-10 aryl or C4-8 heteroaryl, wherein each of C6-10 aryl or C3-8 heteroaryl is optionally substituted with one member selected from fluoro, chloro, bromo, iodo, fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, difluoroethyl, and trifluoroethyl.

### Claim 10

A compound selected from the group consisting of:
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-3-(5-isobutyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-3-(5-cyclopropyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-(5-(trifluoromethyl)-1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-3-(5-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-3-(5-methyl-1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-(furo[2,3-d]pyrimidin-4-ylamino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-3-(5-chloro-1H-pyrazol-3-yl)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(2-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)pyrrolidin-1-yl)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(2-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pyrrolidin-1-yl)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl(thiazolo[5,4-d]pyrimidin-7-ylamino)methyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclopropyl(thiazolo[5,4-d]pyrimidin-7-ylamino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((8-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((8-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(8-methyl-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(8-methyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-fluoro-8-methyl-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-fluoro-8-methyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-5,8-dichloro-2-(cyclopropyl(thiazolo[5,4-d]pyrimidin-7-ylamino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(cyclopropyl(thiazolo[5,4-d]pyrimidin-7-ylamino)methyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-4-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-(imidazo[2,1-f][1,2,4]triazin-4-ylamino)propyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-4-yl)-2-(1-(pyrido[3,2-d]pyrimidin-4-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((6-chloropyrido[3,2-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-(imidazo[2,1-f][1,2,4]triazin-4-ylamino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-3-yl)-2-(1-(pyrido[3,2-d]pyrimidin-4-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((6-chloropyrido[3,2-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(R)-2-(2-(benzyloxy)-1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)-5-chloro-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(R)-2-(2-(benzyloxy)-1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-3-(5-(3-methoxypropyl)-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(R)-5-chloro-2-(2-hydroxy-1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(R)-5-chloro-2-(2-hydroxy-1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-3-yl)-2-(1-(thieno[2,3-d]pyrimidin-4-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-4-yl)-2-(1-(thieno[2,3-d]pyrimidin-4-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-3-(1H-pyrazol-3-yl)-2-(1-(thieno[2,3-d]pyrimidin-4-ylamino)ethyl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-(furo[3,2-d]pyrimidin-4-ylamino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-(furo[3,2-d]pyrimidin-4-ylamino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-chloro-6-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((6-amino-5-((5-fluoropyridin-2-yl)ethynyl)pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-4-oxo-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-4-oxo-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2-amino-5-cyano-6-methylpyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-5-chloro-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((6-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-2-(1-((6-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((6-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-5,8-dichloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(3-(4-bromo-1H-pyrazol-3-yl)-5-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(3-(4-bromo-1H-pyrazol-3-yl)-5-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-5,8-dichloro-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)quinazolin-4(3H)-one;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-5,8-dichloro-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5-(methylsulfonyl)-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((6-chloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((6-chloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((6-amino-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((6-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2-amino-5-cyano-6-methylpyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((6-chloropyrido[3,2-d]pyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2-amino-6-chloro-5-cyanopyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-bromo-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-bromo-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-5-bromo-3-(1H-pyrazol-4-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5-bromo-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-4-oxo-3-(1H-pyrazol-4-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-5-chloro-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(phenyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(phenyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(((2,6-diamino-5-chloropyrimidin-4-yl)amino)(phenyl)methyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(phenyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-5-chloro-2-(((2,6-diamino-5-chloropyrimidin-4-yl)amino)(phenyl)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(phenyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-N-(1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;
(S)-3-amino-N-(1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)pyrazine-2-carboxamide;
(S)—N-(1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;
(S)—N-(1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;
(S)-3-amino-N-(1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazine-2-carboxamide;
(S)-3-amino-N-(1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)pyrazine-2-carboxamide;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((5-bromothieno[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclobutyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclobutyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(cyclobutyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclobutyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclobutyl(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclobutyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((cyclopropyl(4-oxo-3-(1H-pyrazol-3-yl)-8-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)-8-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(4-oxo-3-(1H-pyrazol-3-yl)-8-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)-8-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(6-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(7-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(8-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-(difluoromethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-(difluoromethyl)-6-((1-(8-(difluoromethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(8-(difluoromethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-8-(difluoromethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-((cyclopropyl(8-(difluoromethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)-2-methylpropyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(R)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)-2-hydroxyethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((5-bromothieno[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-3-(5-chloro-1H-pyrazol-3-yl)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(5-fluoro-1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-fluoro-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(R)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diaminopyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((6-amino-5-chloropyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(((6-amino-5-chloropyrimidin-4-yl)amino)(cyclopropyl)methyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-(isothiazolo[5,4-d]pyrimidin-4-ylamino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(trifluoromethyl)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(6,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(6,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(R)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(R)-2,4-diamino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((cyclopropyl(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(4-oxo-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(R)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(R)-2,4-diamino-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(5-chloro-8-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(8-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(6,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(8-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(2-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)pyrrolidin-1-yl)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(5-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(5,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((5-chloro-8-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((cyclopropyl(6,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((8-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-2-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-2-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-3-(5-amino-1H-pyrazol-3-yl)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-(trifluoromethyl)pyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-4-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)thieno[2,3-d]pyrimidine-5-carbonitrile;
(S)-2-(((2-amino-5-cyano-6-methylpyrimidin-4-yl)amino)(cyclopropyl)methyl)-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2,4-diamino-6-((1-(4-oxo-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(4-oxo-3-(1H-pyrazol-4-yl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(4-oxo-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-4-yl)-5-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((cyclopropyl(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-3-(3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(3-methyl-1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5,8-dichloro-3-(3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-3-(3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(3-methyl-1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-5-methyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-methyl-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-((1-(8-chloro-5-methyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-(1-((2-amino-5-chloro-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2-amino-5-chloro-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-8-chloro-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-6-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(6-chloro-5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(7,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-7,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2-amino-5-chloro-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-5,7-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2-amino-5-chloro-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-7,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5,7-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5,7-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-7-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-7-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((5-chloro-7-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-7-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-cyanopyrimidin-4-yl)amino)methyl)-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazoline-8-carbonitrile;
2-((1S)-((6-amino-3-bromo-3aH-pyrazolo[3,4-d]pyrimidin-4-yl)amino)(cyclopropyl)methyl)-5-chloro-3-(4-methyl-1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(4-methyl-1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-chloro-6-(((5-chloro-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((5-chloro-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-cyclopropyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(((2-amino-6-chloro-5-cyanopyrimidin-4-yl)amino)(cyclopropyl)methyl)-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2,4-diamino-6-(((5-chloro-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((5-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoroquinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)ethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2,4-diamino-6-((1-(4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-3,5-diamino-6-chloro-N-(1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazine-2-carboxamide;
(S)-3,5-diamino-6-chloro-N-(1-(5-chloro-8-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazine-2-carboxamide;
(S)-3,5-diamino-6-chloro-N-(1-(5-chloro-8-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazine-2-carboxamide;
(S)-2,4-diamino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-imidazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-imidazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-imidazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-6-fluoro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5,8-dichloro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-imidazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrrol-2-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrrol-2-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile; and
(S)-5-chloro-2-(1-(imidazo[2,1-f][1,2,4]triazin-4-ylamino)ethyl)-3-(1H-pyrrol-2-yl)quinazolin-4(3H)-one;
or a pharmaceutically acceptable salt, isomer, or a mixture thereof.

### Claim 11 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is an atropisomer.

### Claim 12 (depends on 1)

A pharmaceutical composition comprising the compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, and at least one pharmaceutically acceptable vehicle.

### Claim 13 (depends on 1)

A kit comprising the compound of claim 1, or a pharmaceutically acceptable salt, isomer, or a mixture thereof, and a label and/or instructions for use.

### Claim 14 (depends on 1)

The compound, a pharmaceutically acceptable salt, isomer, or a mixture thereof of claim 1 for use in therapy.

### Claim 15 (depends on 1)

The compound of claim 1 having the formula:
wherein n, A, R1, R2, R3, R4, and R5 are defined in claim 1; and,
m is 0 or 1;
or a pharmaceutically acceptable salt thereof.

### Claim 16 (depends on 15)

The compound of claim 15 wherein the heteroaryl of R4 is selected from the group consisting of:

### Claim 17 (depends on 10)

The compound of claim 10, wherein the compound is selected from the group consisting of:
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-3-(5-isobutyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-3-(5-cyclopropyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-(5-(trifluoromethyl)-1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-3-(5-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-3-(5-methyl-1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-(furo[2,3-d]pyrimidin-4-ylamino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-3-(5-chloro-1H-pyrazol-3-yl)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl(thiazolo[5,4-d]pyrimidin-7-ylamino)methyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclopropyl(thiazolo[5,4-d]pyrimidin-7-ylamino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((8-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((8-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(8-methyl-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(8-methyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-fluoro-8-methyl-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-fluoro-8-methyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-5,8-dichloro-2-(cyclopropyl(thiazolo[5,4-d]pyrimidin-7-ylamino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(cyclopropyl(thiazolo[5,4-d]pyrimidin-7-ylamino)methyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-4-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-(imidazo[2,1-f][1,2,4]triazin-4-ylamino)propyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-4-yl)-2-(1-(pyrido[3,2-d]pyrimidin-4-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((6-chloropyrido[3,2-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-(imidazo[2,1-f][1,2,4]triazin-4-ylamino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-3-yl)-2-(1-(pyrido[3,2-d]pyrimidin-4-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((6-chloropyrido[3,2-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(R)-2-(2-(benzyloxy)-1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)-5-chloro-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(R)-2-(2-(benzyloxy)-1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-3-(5-(3-methoxypropyl)-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(R)-5-chloro-2-(2-hydroxy-1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(R)-5-chloro-2-(2-hydroxy-1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-3-yl)-2-(1-(thieno[2,3-d]pyrimidin-4-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-3-(1H-pyrazol-4-yl)-2-(1-(thieno[2,3-d]pyrimidin-4-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-3-(1H-pyrazol-3-yl)-2-(1-(thieno[2,3-d]pyrimidin-4-ylamino)ethyl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-(furo[3,2-d]pyrimidin-4-ylamino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-(furo[3,2-d]pyrimidin-4-ylamino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-chloro-6-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((6-amino-5-((5-fluoropyridin-2-yl)ethynyl)pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-4-oxo-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-4-oxo-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2-amino-5-cyano-6-methylpyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-5-chloro-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((6-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-2-(1-((6-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((6-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-5,8-dichloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(3-(4-bromo-1H-pyrazol-3-yl)-5-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(3-(4-bromo-1H-pyrazol-3-yl)-5-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-5,8-dichloro-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)quinazolin-4(3H)-one;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-5,8-dichloro-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5-(methylsulfonyl)-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((6-chloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)propyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((6-chloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((6-amino-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((6-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2-amino-5-cyano-6-methylpyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((6-chloropyrido[3,2-d]pyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2-amino-6-chloro-5-cyanopyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-bromo-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-bromo-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-5-bromo-3-(1H-pyrazol-4-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-5-bromo-3-(1H-pyrazol-3-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)propyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-4-oxo-3-(1H-pyrazol-4-yl)-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)propyl)-3,4-dihydroquinazoline-5-carbonitrile;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-5-chloro-2-(1-(thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(phenyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(phenyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(((2,6-diamino-5-chloropyrimidin-4-yl)amino)(phenyl)methyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(phenyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-5-chloro-2-(((2,6-diamino-5-chloropyrimidin-4-yl)amino)(phenyl)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(phenyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-N-(1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;
(S)-3-amino-N-(1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)pyrazine-2-carboxamide;
(S)—N-(1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;
(S)—N-(1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;
(S)-3-amino-N-(1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazine-2-carboxamide;
(S)-3-amino-N-(1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)propyl)pyrazine-2-carboxamide;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((5-bromothieno[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclobutyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclobutyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(cyclobutyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclobutyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclobutyl(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclobutyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((cyclopropyl(4-oxo-3-(1H-pyrazol-3-yl)-8-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)-8-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(4-oxo-3-(1H-pyrazol-3-yl)-8-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)-8-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(6-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(7-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(8-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-(difluoromethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-(difluoromethyl)-6-((1-(8-(difluoromethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(8-(difluoromethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-8-(difluoromethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-((cyclopropyl(8-(difluoromethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)-2-methylpropyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(R)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)-2-hydroxyethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((5-bromothieno[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-3-(5-chloro-1H-pyrazol-3-yl)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(5-fluoro-1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-fluoro-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(R)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diaminopyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((6-amino-5-chloropyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(((6-amino-5-chloropyrimidin-4-yl)amino)(cyclopropyl)methyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-(isothiazolo[5,4-d]pyrimidin-4-ylamino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(trifluoromethyl)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(6,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(6,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(R)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(R)-2,4-diamino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((cyclopropyl(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(4-oxo-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(R)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(R)-2,4-diamino-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(5-chloro-8-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(8-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(6,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(8-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(5-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((1-(5,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(difluoromethyl)-6-((1-(6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((5-chloro-8-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-((cyclopropyl(6,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((8-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-2-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-4-amino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-2-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-3-(5-amino-1H-pyrazol-3-yl)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-8-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(1-((2,6-diamino-5-(trifluoromethyl)pyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-4-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)thieno[2,3-d]pyrimidine-5-carbonitrile;
(S)-2-(((2-amino-5-cyano-6-methylpyrimidin-4-yl)amino)(cyclopropyl)methyl)-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2,4-diamino-6-((1-(4-oxo-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(4-oxo-3-(1H-pyrazol-4-yl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((cyclopropyl(4-oxo-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-4-yl)-5-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-pyrazol-3-yl)-5-(trifluoromethyl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((cyclopropyl(5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-3-(3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(3-methyl-1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5,8-dichloro-3-(3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-3-(3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(3-methyl-1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-5-methyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-methyl-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-((1-(8-chloro-5-methyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)-6-(difluoromethyl)pyrimidine-5-carbonitrile;
(S)-2-(1-((2-amino-5-chloro-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-5-chloro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2-amino-5-chloro-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-8-chloro-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-6-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5-(difluoromethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(6-chloro-5-(difluoromethyl)-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(7,8-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-7,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2-amino-5-chloro-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-5,7-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(1-((2-amino-5-chloro-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-7,8-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5,7-difluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-5,7-difluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-7-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-7-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((5-chloro-7-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-7-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-(cyclopropyl((2,6-diamino-5-cyanopyrimidin-4-yl)amino)methyl)-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazoline-8-carbonitrile;
2-((1S)-((6-amino-3-bromo-3aH-pyrazolo[3,4-d]pyrimidin-4-yl)amino)(cyclopropyl)methyl)-5-chloro-3-(4-methyl-1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(4-methyl-1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2-amino-4-chloro-6-(((5-chloro-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2-amino-4-(((5-chloro-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)-6-methylpyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-cyclopropyl-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(((2-amino-6-chloro-5-cyanopyrimidin-4-yl)amino)(cyclopropyl)methyl)-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2,4-diamino-6-(((5-chloro-3-(4-methyl-1H-pyrazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5,8-dichloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-5,8-dichloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)propyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)propyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((5-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-pyrazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-6-fluoro-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-3-(4-bromo-1H-pyrazol-3-yl)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoroquinazolin-4(3H)-one;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(1-((2,6-diamino-5-cyanopyrimidin-4-yl)amino)ethyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazoline-8-carbonitrile;
(S)-2,4-diamino-6-((1-(4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-3-(1H-pyrazol-3-yl)quinazolin-4(3H)-one;
(S)-3,5-diamino-6-chloro-N-(1-(5-chloro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazine-2-carboxamide;
(S)-3,5-diamino-6-chloro-N-(1-(5-chloro-8-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazine-2-carboxamide;
(S)-3,5-diamino-6-chloro-N-(1-(5-chloro-8-fluoro-4-oxo-3-(1H-pyrazol-4-yl)-3,4-dihydroquinazolin-2-yl)ethyl)pyrazine-2-carboxamide;
(S)-2,4-diamino-6-((1-(8-chloro-6-fluoro-4-oxo-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-6-fluoro-3-(1H-imidazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-(((8-chloro-6-fluoro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)butyl)-3-(1H-imidazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)butyl)amino)pyrimidine-5-carbonitrile;
(S)-8-chloro-2-(1-((2,6-diamino-5-chloropyrimidin-4-yl)amino)ethyl)-6-fluoro-3-(1H-imidazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(8-chloro-6-fluoro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5,8-dichloro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-5-chloro-2-(cyclopropyl((2,6-diamino-5-chloropyrimidin-4-yl)amino)methyl)-3-(1H-imidazol-4-yl)quinazolin-4(3H)-one;
(S)-2,4-diamino-6-((1-(5-chloro-3-(1H-imidazol-4-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrrol-2-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile;
(S)-2,4-diamino-6-((1-(5-chloro-4-oxo-3-(1H-pyrrol-2-yl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile; and
(S)-5-chloro-2-(1-(imidazo[2,1-f][1,2,4]triazin-4-ylamino)ethyl)-3-(1H-pyrrol-2-yl)quinazolin-4(3H)-one;
or a pharmaceutically acceptable salt, isomer, or a mixture thereof.

### Claim 18 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt thereof.

### Claim 19 (depends on 10)

The compound of claim 10, or a pharmaceutically acceptable salt thereof.

### Claim 20 (depends on 17)

The compound of claim 17, or a pharmaceutically acceptable salt thereof.