# US 10,308,608 B2 · Histone deacetylase inhibitors

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- Number: US 10,308,608 B2
- Document ID: US10308608B2
- Status: Granted
- Kind: B2
- Application number: 16/047,179
- Filed: 2018-07-27
- Published: 2018-12-27
- Granted: 2019-06-04
- Earliest claimed: 2015-07-02
- Assignees: Biomarin Pharmaceutical Inc.
- Applicants: Biomarin Pharmaceutical Inc.
- Inventors: Shripad Bhagwat; Gregory Luedtke; Alexander Bridges
- Web page: https://patentgrep.com/patent/US10308608B2

## CPC

- C07D 211/46: having a hydrogen atom as the second substituent in position 4
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61P 25/14: for treating abnormal movements, e.g. chorea, dyskinesia
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 25/30: for treating abuse or dependence
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 35/00: Antineoplastic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 205/04: having no double bonds between ring members or between ring members and non-ring members
- C07D 207/12: Oxygen or sulfur atoms
- C07D 207/14: Nitrogen atoms not forming part of a nitro radical
- C07D 211/54: Sulfur atoms
- C07D 211/58: attached in position 4
- C07D 223/08: Oxygen atoms
- C07D 223/12: Nitrogen atoms not forming part of a nitro radical
- C07D 451/02: containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D 451/04: with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D 451/06: Oxygen atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided herein are compounds and methods for inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).

## Claims

### Claim 1

A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 3 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 4 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 5 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 6 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 7 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 8 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 9 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 10 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 11 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 12 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 13 (depends on 1)

The compound or salt of claim 1, having a structure:

### Claim 14 (depends on 1)

The compound or salt of claim 1, having a structure: