Inhibitors of creatine transport and uses thereof

A compound having the structure:

• wherein Q1 is
• m is 1 or 2;
• R7 is hydrogen;
• one R8 combines with R12 with the atoms to which they are attached to form an optionally substituted C3-C4 heterocycle;
• a second R8, if present, is hydrogen, deuterium, halo, NH2, optionally substituted C1-C3 alkyl, or combines with an R9 and with the atoms to which they are attached to form an optionally substituted C3-C6 cycloalkyl ring;
• or combines with R10 or R11 and with the atoms to which they are attached to form an optionally substituted C3-C4 cycloalkyl ring;
• each R9 is independently hydrogen, deuterium, halo, NH2, optionally substituted C1-C3 alkyl or combines with the second R8, if present, and with the atoms to which they are attached to form an optionally substituted C3-C6 cycloalkyl ring;
• or combines with R10 or R11 and with the atoms to which they are attached to form an optionally substituted C3-C4 cycloalkyl ring;
• R10 and R11 are independently hydrogen, deuterium, optionally substituted C1-C4 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl or R10 and R11 combine with the atoms to which they are attached to form an optionally substituted C3-C6 cycloalkyl ring;
• or R10 or R11 combine with R8 or R9 with the atoms to which they are attached to form an optionally substituted C3-C4 cycloalkyl ring;
• or R10 or R11 combine with R12 with the atoms to which they are attached to form an optionally substituted C3-C4 heterocycle;
• R12 is hydrogen, optionally substituted C1-C6 alkyl, or R12 combines with R8 or R9 with the atoms to which they are attached to form an optionally substituted C3-C4 heterocycle, or R12 combines with R10 or R11 with the atoms to which they are attached to form an optionally substituted C3-C4 heterocycle;
• wherein if m is 1 and R10 is methyl then at least one of R9, and R11 is not hydrogen;
• or a pharmaceutically acceptable salt thereof.