# US 10,308,408 B2 · Packaging for adhesive patch containing rivastigmine

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- Number: US 10,308,408 B2
- Document ID: US10308408B2
- Status: Granted
- Kind: B2
- Application number: 15/310,412
- Filed: 2015-05-14
- Published: 2017-06-01
- Granted: 2019-06-04
- Earliest claimed: 2014-05-15
- Assignees: Nichiban Co., Ltd.
- Applicants: Nichiban Co., Ltd.
- Inventors: Shuta Nakanami; Kanako Inagaki
- Web page: https://patentgrep.com/patent/US10308408B2

## CPC

- B65D 65/40: Applications of laminates for particular packaging purposes {(B65D1/0215, B65D1/28, B65D3/22, B65D5/0281, B65D5/563, B65D9/30, B65D29/02, B65D31/02, B65D75/26, B65D77/2024, B65D81/1275, B65D81/3811, B65D81/3823, B65D81/3834, B65D81/3846, B65D81/3858, B65D81/3874, B65D81/3886, B65D81/3897 take precedence; laminates per se or laminated packages characterised by the composition or)}
- A61J 1/00: Containers specially adapted for medical or pharmaceutical purposes (capsules or the like for oral use A61J3/07; specially adapted for surgical or diagnostic appliances or instruments A61B50/30; containers for radioactive substances G21F5/00)
- A61K 9/7007: {Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence)}
- A61K 9/7061: {Polyacrylates}
- A61K 31/27: of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- B32B 7/04: Interconnection of layers
- B32B 15/08: of synthetic resin
- B32B 15/082: comprising vinyl resins; comprising acrylic resins
- B32B 15/085: comprising polyolefins
- B32B 15/088: comprising polyamides
- B32B 15/09: comprising polyesters
- B32B 15/12: of paper or cardboard
- B32B 15/20: comprising aluminium or copper {(B32B15/016 and B32B15/017 take precedence)}
- B32B 27/08: of synthetic resin
- B32B 27/28: comprising synthetic resins not wholly covered by any one of the sub-groups {B32B27/30 - B32B27/42}
- B32B 27/281: {comprising polyimides}
- B32B 27/302: {comprising aromatic vinyl (co)polymers, e.g. styrenic (co)polymers}
- B32B 27/306: {comprising vinyl acetate or vinyl alcohol (co)polymers}
- B32B 27/308: {comprising acrylic (co)polymers}
- B32B 27/32: comprising polyolefins {(comprising vinyl (co)polymers or acrylic (co)polymers B32B27/30)}
- B32B 27/34: comprising polyamides
- B32B 27/36: comprising polyesters
- B32B 27/365: {comprising polycarbonates}
- B65B 7/02: Closing containers or receptacles deformed by, or taking-up shape, of, contents, e.g. bags, sacks
- B65B 31/00: Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65D 77/00: Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B32B 2250/03: 3 layers
- B32B 2250/04: 4 layers
- B32B 2307/31: Heat sealable
- B32B 2307/714: Inert, i.e. inert to chemical degradation, corrosion
- B32B 2307/7244: Oxygen barrier
- B32B 2307/748: Releasability
- B32B 2439/46: Bags
- B32B 2439/80: Medical packaging
- B65B 5/045: {in bags}
- B65B 31/04: Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied
- B65B 51/10: Applying or generating heat or pressure or combinations thereof {(welding of plastics per se B29C65/02; closing plastic tube ends in general B29C57/10)}
- B65D 77/04: Articles or materials enclosed in two or more containers disposed one within another
- B65D 81/2084: {in a flexible container}
- B65D 81/266: {for absorbing gases, e.g. oxygen absorbers or desiccants (B65D51/244, B65D51/30 take precedence)}
- B65D: CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- B32B: LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B65B: MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING (bundling and pressing devices for cigars A24C1/44; devices for tensioning and securing binders adapted to be supported by the article or articles to be bound B25B25/00; applying closure members to bottles, jars or similar containers B67B1/00-B67B6/00; concurrent cleaning, filling and closing of bottles B67C7/00; emptying bottles, jars, cans, casks, barrels or similar containers B67C9/00)

## Abstract

To provide a packaging for a rivastigmine-containing adhesive patch having excellent temporal stability of rivastigmine, an adhesive patch product including the adhesive patch and a packaging bag, and a method for manufacturing the same. An adhesive patch product including a packaging bag formed from a laminate of at least three layers including an ethylene-vinyl alcohol copolymer film and a rivastigmine-containing adhesive patch housed in the packaging bag and having a residual oxygen concentration of 10% by volume or less in the packaging bag, and a method for manufacturing the same are provided. In addition, a packaging for a rivastigmine-containing adhesive patch formed from a laminate including an ethylene-vinyl alcohol copolymer film and having a residual oxygen concentration of 10% by volume or less therein is provided.

## Claims

### Claim 1

An adhesive patch product comprising a packaging bag and a rivastigmine-containing adhesive patch housed in the packaging bag, wherein
the packaging bag is formed from a laminate of at least three layers including an ethylene-vinyl alcohol copolymer film, wherein the content of an ethylene unit in the ethylene-vinyl alcohol copolymer is from 10% to 50% by mol,
the laminate has a lamination configuration having a heat-sealable ethylene-vinyl alcohol copolymer film as an innermost layer of the packaging bag, an oxygen blocking layer as a layer outside the ethylene-vinyl alcohol copolymer film, and an outer layer as a layer outside the oxygen blocking layer, or
the laminate has a lamination configuration having a sealant layer as an innermost layer of the packaging bag, an ethylene-vinyl alcohol copolymer film as a layer outside the sealant layer, an oxygen blocking layer as a layer outside the ethylene-vinyl alcohol copolymer film, and an outer layer as a layer outside the oxygen blocking layer, and
a residual oxygen concentration in the packaging bag is 10% by volume or less.

### Claim 2 (depends on 1)

The adhesive patch product according to claim 1, wherein the adhesive patch includes:
a support, a rivastigmine-containing drug storage layer disposed on at least one surface of the support, an adhesive layer disposed on the drug storage layer, and release paper disposed on the adhesive layer; or
a support, an adhesive layer disposed on at least one surface of the support, a rivastigmine-containing drug storage layer disposed on the adhesive layer, and release paper disposed on the drug storage layer; or
a support, a rivastigmine-containing adhesive layer disposed on at least one surface of the support, and release paper disposed on the rivastigmine-containing adhesive layer.

### Claim 3 (depends on 2)

The adhesive patch product according to claim 2, wherein, in the adhesive patch,
the content of rivastigmine in the rivastigmine-containing drug storage layer is from 10% to 40% by mass based on a total mass of the drug storage layer and the adhesive layer, or
the content of rivastigmine in the rivastigmine-containing adhesive layer is from 10% to 40% by mass based on a total mass of the rivastigmine-containing adhesive layer.

### Claim 4 (depends on 2)

The adhesive patch product according to claim 2, wherein the adhesive layer or the rivastigmine-containing adhesive layer contains an acrylic adhesive.

### Claim 5 (depends on 1)

The adhesive patch product according to claim 1, wherein the oxygen blocking layer comprises an aluminum foil.

### Claim 6 (depends on 1)

The adhesive patch product according to claim 1, wherein the laminate has the lamination configuration having the heat-sealable ethylene-vinyl alcohol copolymer film as an innermost layer of the packaging bag, the oxygen blocking layer as a layer outside the ethylene-vinyl alcohol copolymer film, and the outer layer as a layer outside the oxygen blocking layer.

### Claim 7 (depends on 1)

The adhesive patch product according to claim 1, wherein no antioxidant is added to the adhesive in the rivastigmine-containing adhesive patch.