# US 10,307,753 B2 · Pipette tips

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- Number: US 10,307,753 B2
- Document ID: US10307753B2
- Status: Granted
- Kind: B2
- Application number: 15/444,883
- Filed: 2017-02-28
- Published: 2017-06-15
- Granted: 2019-06-04
- Earliest claimed: 2010-01-22
- Assignees: Biotix, Inc.
- Applicants: Biotix, Inc.
- Inventors: Arta Motadel; Peter Paul Blaszcak; Phillip Chad Hairfield; Sean Michael Callahan
- Web page: https://patentgrep.com/patent/US10307753B2

## CPC

- B01L 3/0279: {co-operating with positive ejection means}
- B01L 3/0275: {Interchangeable or disposable dispensing tips}
- Y10T 436/2575: Volumetric liquid transfer
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.

## Claims

### Claim 1

A pipette tip comprising an exterior surface, an interior surface, a proximal region, a distal region and a junction between the proximal region and the distal region,
which proximal region comprises:
an annular flange at the proximal terminus of the proximal region;
a plurality of axially oriented ribs circumferentially spaced around the exterior surface of the proximal region;
a wall thickness of about 0.005 inches to about 0.015 inches (i) at or near a sealing zone for a dispensing device, and (ii) at a portion between the ribs;
the ribs or portion thereof extend over the sealing zone; and
which interior surface is substantially smooth and uniform and defines a substantially frustrum-shaped void.

### Claim 2 (depends on 1)

The pipette tip of claim 1, wherein one end of the ribs is co-extensive with, or terminates at the annular flange.

### Claim 3 (depends on 2)

The pipette tip of claim 2, wherein one end of the ribs is co-extensive with, or terminates at a junction between the annular flange and the proximal region.

### Claim 4 (depends on 3)

The pipette tip of claim 3, wherein the ribs extend from the junction between the annular flange and the proximal region to the junction between the proximal region and distal region.

### Claim 5 (depends on 1)

The pipette tip of claim 1, wherein the exterior surface of the distal region comprises a step at the junction between the proximal region and the distal region.

### Claim 6 (depends on 1)

The pipette tip of claim 1, wherein the wall thickness at or near the proximal terminus of the distal region is substantially similar to the wall thickness at or near the distal terminus of the proximal region.

### Claim 7 (depends on 1)

The pipette tip of claim 1, wherein the proximal region comprises an annular groove on the interior surface.

### Claim 8 (depends on 7)

The pipette tip of claim 7, wherein the sealing zone is located at a position in the pipette tip interior proximal of the annular groove.

### Claim 9 (depends on 7)

The pipette tip of claim 7, wherein the sealing zone is located at a position in the pipette tip interior distal of the annular groove.

### Claim 10 (depends on 1)

The pipette tip of claim 1, wherein the wall thickness of the proximal region is about 0.005 inches to about 0.008 inches at or near the sealing zone for a dispensing device and at the portion between the ribs.

### Claim 11 (depends on 1)

The pipette tip of claim 1, wherein the axially oriented ribs are of uniform thickness.

### Claim 12 (depends on 1)

The pipette tip of claim 1, wherein:
the distal region wall thickness tapers from (a) a point at or between (i) about the junction of the proximal region and distal region to (ii) about one-quarter of the axial distance from the terminus of the distal region to the junction, to (b) the distal region terminus, and
the wall thickness at the distal region terminus is about 0.0040 inches to about 0.0055 inches.

### Claim 13 (depends on 12)

The pipette tip of claim 12, wherein the wall thickness at the distal region terminus is about 0.0043 inches to about 0.0050 inches.

### Claim 14 (depends on 13)

The pipette tip of claim 13, wherein the wall thickness at the distal region terminus is about 0.0044 inches to about 0.0049 inches.

### Claim 15 (depends on 12)

The pipette tip of claim 12, wherein the interior surface of the distal region is substantially smooth.

### Claim 16 (depends on 12)

The pipette tip of claim 12, wherein the pipette tip retains less than 0.065% of the fluid drawn into the pipette tip after the liquid is dispensed.

### Claim 17 (depends on 12)

The pipette tip of claim 12, wherein the pipette tip retains no more than 0.00012% of the fluid drawn into the pipette tip after the liquid is dispensed.

### Claim 18 (depends on 1)

The pipette tip of claim 1, wherein the wall thickness of the proximal region is uniform.

### Claim 19 (depends on 12)

The pipette tip of claim 12, wherein the wall thickness gradually tapers from about the junction of the proximal region and the distal region to the distal region terminus.

### Claim 20 (depends on 1)

The pipette tip of claim 1, wherein the proximal region comprises 4 or more ribs.

### Claim 21 (depends on 1)

The pipette tip of claim 1, wherein the proximal region comprises about 6 to about 60 ribs.

### Claim 22 (depends on 1)

The pipette tip of claim 1, wherein the wall thickness of the proximal region is about 0.010 inches to about 0.013 inches at or near the sealing zone for a dispensing device and at the portion between the ribs.

### Claim 23 (depends on 1)

The pipette tip of claim 1, wherein the wall thickness of the proximal region is about 0.010 inches to about 0.015 inches at or near the sealing zone for a dispensing device and at the portion between the ribs.