# US 10,307,592 B1 · Method and system to accelerate consolidation of specific memories using transcranial stimulation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,592 B1 - Document ID: US10307592B1 - Status: Granted - Kind: B1 - Application number: 15/332,787 - Filed: 2016-10-24 - Granted: 2019-06-04 - Earliest claimed: 2015-10-23 - Assignees: HRL Laboratories, LLC - Applicants: HRL Laboratories, LLC - Inventors: Praveen K. Pilly; Michael D. Howard; Jaehoon Choe; Rajan Bhattacharyya - Web page: https://patentgrep.com/patent/US10307592B1 ## CPC - A61N 1/36025: {for treating a mental or cerebral condition} - A61B 5/374: Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves - A61B 5/4812: {Detecting sleep stages or cycles} - A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)} - A61N 1/0456: {Specially adapted for transcutaneous electrical nerve stimulation [TENS]} - A61N 1/3603: {Control systems} - A61N 1/0476: {Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)} - A61N 1/0484: {Garment electrodes worn by the patient} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Described is a system for consolidation of specific memories of events. A sleep state detector assesses a subject's sleep state from neural recordings obtained from a high-density electroencephalogram (HD-EEG) device. During a memory encoding phase, a high-definition transcranial current stimulation (HD-tCS) system simultaneously applies a spatiotemporal amplitude-modulated pattern (STAMP) tag and a transcranial direct current stimulation (tDCS) signal to the subject as an event is experienced by the subject. During a memory consolidation phase, the HD-tCS system applies a transcranial alternating current stimulation (tACS) signal to the subject during a sleep or quiet waking state of the subject. ## Claims ### Claim 1 A system for memory consolidation, the system comprising: a high-definition transcranial current stimulation (HD-tCS) system; a high-density electroencephalogram (HD-EEG) device for generating neural recordings; one or more processors and a non-transitory computer-readable medium having executable instructions encoded thereon such that when executed, the one or more processors perform an operation of generating a spatiotemporal amplitude-modulated pattern (STAMP) tag; and a sleep state detector for assessing the sleep state from the neural recordings, wherein during a memory encoding phase, the HD-tCS system simultaneously applies the STAMP tag and a transcranial direct current stimulation (tDCS) signal during an event, and wherein during a memory consolidation phase, the HD-tCS system applies a transcranial alternating current stimulation (tACS) signal during a sleep or quiet waking state. ### Claim 2 (depends on 1) The system as set forth in claim 1, wherein the STAMP tag is a weighted combination of endogenous brain rhythms. ### Claim 3 (depends on 1) The system as set forth in claim 1, wherein the HD-tCS system applies the STAMP tag during the sleep or quiet waking state to stimulate replays of a memory of the event and consolidate the memory. ### Claim 4 (depends on 1) The system as set forth in claim 1, wherein when a slow-wave-sleep (SWS) state is detected, the sleep state detector signals the HD-tCS system to apply a temporally compressed version of the STAMP tag. ### Claim 5 (depends on 1) The system as set forth in claim 1, wherein the HD-tCS system applies the tACS signal when the sleep state detector detects non-rapid eye movement (NREM) sleep. ### Claim 6 (depends on 1) The system as set forth in claim 1, wherein the event can be re-encoded in a memory by deliberate recall using a video of the event. ### Claim 7 A method for memory consolidation, comprising acts of: generating neural recordings using a high-density electroencephalogram (HD-EEG) device; assessing the sleep state from the neural recordings using a sleep state detector; generating a spatiotemporal amplitude-modulated pattern (STAMP) tag; during a memory encoding phase, simultaneously applying, using a high-definition transcranial current stimulation (HD-tCS) system, the STAMP tag and a transcranial direct current stimulation (tDCS) signal during an event; and during a memory consolidation phase, applying, using the HD-tCS system, a transcranial alternating current stimulation (tACS) signal during a sleep or quiet waking state. ### Claim 8 (depends on 7) The method as set forth in claim 7, wherein the STAMP tag is a weighted combination of endogenous brain rhythms. ### Claim 9 (depends on 7) The method as set forth in claim 7, wherein the HD-tCS system applies the STAMP tag during the sleep or quiet waking state to stimulate replays of a memory of the event and consolidate the memory. ### Claim 10 (depends on 7) The method as set forth in claim 7, wherein when a slow-wave-sleep (SWS) state is detected, the sleep state detector signals the HD-tCS system to apply a temporally compressed version of the STAMP tag. ### Claim 11 (depends on 7) The method as set forth in claim 7, wherein the HD-tCS system applies the tACS signal when the sleep state detector detects non-rapid eye movement (NREM) sleep. ### Claim 12 (depends on 7) The method as set forth in claim 7, wherein the event can be re-encoded in the memory by deliberate recall using a video of the event. ### Claim 13 A computer program product for memory consolidation, the computer program product comprising: computer-readable instructions stored on a non-transitory computer-readable medium that are executable by a computer having one or more processors for causing the processor to perform operations of: generating neural recordings using a high-density electroencephalogram (HD-EEG) device; assessing the sleep state from the neural recordings using a sleep state detector; generating a spatiotemporal amplitude-modulated pattern (STAMP) tag; during a memory encoding phase, simultaneously applying, using a high-definition transcranial current stimulation (HD-tCS) system, the STAMP tag and a transcranial direct current stimulation (tDCS) signal during an event; and during a memory consolidation phase, applying, using the HD-tCS system, a transcranial alternating current stimulation (tACS) signal during a sleep or quiet waking state.