# US 10,307,591 B2 · Topical neurological stimulation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,591 B2 - Document ID: US10307591B2 - Status: Granted - Kind: B2 - Application number: 15/650,228 - Filed: 2017-07-14 - Published: 2017-11-02 - Granted: 2019-06-04 - Earliest claimed: 2013-05-30 - Assignees: Neurostim Solutions, LLC - Applicants: Graham H. Creasey; Hoo-Min Toong - Inventors: Graham H. Creasey; Hoo-Min Toong - Web page: https://patentgrep.com/patent/US10307591B2 ## CPC - A61N 1/0452: {Specially adapted for transcutaneous muscle stimulation [TMS]} - A61B 5/388: Nerve conduction study, e.g. detecting action potential of peripheral nerves - A61N 1/0456: {Specially adapted for transcutaneous electrical nerve stimulation [TENS]} - A61N 1/0476: {Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)} - A61N 1/0492: {Patch electrodes (A61N1/0412, A61N1/0428 take precedence)} - A61N 1/36003: {of motor muscles, e.g. for walking assistance} - A61N 1/36007: {of urogenital or gastrointestinal organs, e.g. for incontinence control} - A61N 1/36031: {using physiological parameters for adjustment} - A61N 1/36034: {specified by the stimulation parameters} - A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)} - A61N 1/36021: {for treatment of pain} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor. ## Claims ### Claim 1 A topical nerve stimulator system comprising: a flexible dermis conforming patch defining a surface and formed by a substrate; electrodes positioned on the patch proximal the surface and directly coupled to the substrate; electronic circuitry embedded in the patch comprising a system on a chip that is directly coupled to the substrate and comprising: an electrical signal generator configured to electrically activate the electrodes; a signal receiver in communication with the electrical signal generator; an antenna; a transmitter; and a receiver; a remote control device in wireless communication with the electronic circuitry, the remote control device configured to provide a signal to start stimulation on a user via the electrodes, the signal generated in response to the user interacting with the remote control device. ### Claim 2 (depends on 1) The topical nerve stimulator system of claim 1, the surface further comprises adhesive. ### Claim 3 (depends on 1) The topical nerve stimulator system of claim 1, further comprising a feedback sensor on the patch coupled to the substrate and configured to sense muscle and/or nerve activation and communicate data to the remote control device. ### Claim 4 (depends on 1) The topical nerve stimulator system of claim 1, the remote control device is a smartphone and the signal is generated via a smartphone app. ### Claim 5 (depends on 1) The topical nerve stimulator system of claim 1, the remote control device is a key fob controller comprising a button and the signal is generated via a pressing of the button. ### Claim 6 (depends on 3) The topical nerve stimulator system of claim 3, the stimulation based on a stimulation pattern that is revised in response to the sensed muscle and/or nerve activation. ### Claim 7 (depends on 1) The topical nerve stimulator system of claim 1, the electrodes configured to stimulate a mammalian nerve. ### Claim 8 (depends on 1) The topical nerve stimulator system of claim 1, the remote control device comprising a user interface configured to provide visual, audio and tactile feedback to a user. ### Claim 9 A method for controlling a body function of a user comprising: applying a flexible dermis conforming patch to a dermis of the user in proximity to a selected nerve, the patch formed by a substrate and comprising electrodes directly coupled to the substrate, electronic circuitry embedded in the patch comprising a system on a chip that is directly coupled to the substrate and comprising an electrical signal generator configured to electrically activate the electrodes, a signal receiver in communication with the electric signal generator, an antenna, a transmitter and a receiver; applying an electrical signal generated by the flexible dermis conforming patch to the selected nerve; and sensing nerve stimulation response; the applying in response to a signal to start stimulation on the user via the electrodes from a remote control device in wireless communication with the electronic circuitry, the signal generated in response to the user interacting with the remote control device. ### Claim 10 (depends on 9) The method of claim 9 further comprising monitoring the nerve response to the electrical signal and adjusting a nerve stimulation pattern that is revised in response to the nerve response. ### Claim 11 (depends on 9) The method of claim 9 further comprising monitoring a muscle response to the nerve stimulation and adjusting a nerve stimulation pattern that is revised in response to the nerve response. ### Claim 12 (depends on 9) The method of claim 9, the remote control device is a smartphone and the signal is generated via a smartphone app. ### Claim 13 (depends on 9) The method of claim 9, the remote control device is a key fob controller comprising a button and the signal is generated via a pressing of the button. ### Claim 14 (depends on 9) The method of claim 9 further comprising applying the flexible dermis conforming patch to the dermis with adhesive. ### Claim 15 (depends on 9) The method of claim 9 further comprising applying more than one flexible dermis conforming patches to the dermis. ### Claim 16 (depends on 9) The method of claim 9 further comprising stimulating more than one nerve with one or more flexible dermis conforming patches to create a nerve stimulation pattern. ### Claim 17 (depends on 9) The method of claim 9 further comprising applying the electrical signal to a selected portion of a nerve. ### Claim 18 (depends on 9) The method of claim 9 further comprising selectively adjusting a strength of the electrical signal. ### Claim 19 (depends on 9) The method of claim 9 further comprising selectively adjusting a shape of the electrical signal. ### Claim 20 (depends on 9) The method of claim 9 further comprising receiving a signal feedback from a stimulated nerve. ### Claim 21 (depends on 9) The method of claim 9 further comprising receiving feedback from a stimulated nerve and adjusting the electrical signal based on the feedback. ### Claim 22 (depends on 9) The method of claim 9, the remote control device comprising a user interface configured to provide visual, audio and tactile feedback to a user. ### Claim 23 A topical nerve stimulator patch comprising: a substrate; electrodes positioned on the patch proximal the surface and directly coupled to the substrate; electronic circuitry embedded in the patch comprising a system on a chip that is directly coupled to the substrate and comprising: an electrical signal generator configured to electrically activate the electrodes; a signal receiver in communication with the electrical signal generator; an antenna; a transmitter; and a receiver; the electrical circuitry configured to be in wireless communication with a remote control device, the remote control device configured to provide a signal to start stimulation on a user via the electrodes, the signal generated in response to the user interacting with the remote control device. ### Claim 24 (depends on 23) The topical nerve stimulator patch of claim 23, further comprising a feedback sensor on the patch coupled to the substrate and configured to sense muscle and/or nerve activation and communicate data to the remote control device. ### Claim 25 (depends on 24) The topical nerve stimulator patch of claim 24, the stimulation based on a stimulation pattern that is revised in response to the sensed muscle and/or nerve activation.