# US 10,307,523 B2 · Blood purification device

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,307,523 B2
- Document ID: US10307523B2
- Status: Granted
- Kind: B2
- Application number: 15/123,349
- Filed: 2015-04-24
- Published: 2017-10-26
- Granted: 2019-06-04
- Earliest claimed: 2015-04-24
- Assignees: Nipro Corporation
- Applicants: Nipro Corporation
- Inventors: Mitsutaka Ueda; Tomoyuki Matsumoto; Shogo Okada; Hiroomi Nakano
- Web page: https://patentgrep.com/patent/US10307523B2

## CPC

- A61M 1/1621: {Constructional aspects thereof (semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00)}
- A61M 1/1641: {linked by pistons}
- A61M 1/3424: {Substitution fluid path}
- F04B 9/02: the means being mechanical
- F04B 9/04: the means being cams, eccentrics or pin-and-slot mechanisms
- F04B 23/04: Combinations of two or more pumps
- F04B 23/06: the pumps being all of reciprocating positive-displacement type
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- F04B: POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS (machines for liquids, or pumps, of rotary-piston or oscillating-piston type F04C; non-positive-displacement pumps F04D; pumping of fluid by direct contact of another fluid or by using inertia of fluid to be pumped F04F)

## Abstract

In a blood purification device containing a blood purifier, a blood circuit, a blood pump, and a dialysate line having a fresh dialysate supply line and a used dialysate discharge line, a pair of plunger pumps are disposed in the dialysate line. The pair of plunger pumps are synchronized so that delivery of a fresh dialysate from one plunger pump and suction of a used dialysate into the other plunger pump simultaneously occur and the stroke of at least one of the pair of plunger pumps is made variable.

## Claims

### Claim 1

A blood purification device comprising:
a blood purifier;
a blood circuit;
a blood pump; and
a dialysate line having a fresh dialysate supply line and a used dialysate discharge line, wherein:
a pair of plunger pumps are disposed in the dialysate line,
the pair of plunger pumps are synchronized so that delivery of a fresh dialysate from one plunger pump and suction of a used dialysate into the other plunger pump simultaneously occur,
a stroke of at least one of the pair of plunger pumps is variable, and
the pair of plunger pumps are disposed in a mirror-target manner with respect to a rotation shaft of a synchronization motor and are individually connected to the synchronization motor located in a central portion of the rotation shaft through drive joints.

### Claim 2 (depends on 1)

The blood purification device according to claim 1, wherein a stroke of the plunger pump on a fresh dialysate delivery side is fixed and adjustment of a stroke of the plunger pump on a used dialysate suction side is performed by an angle adjustment motor adjusting a horizontal inclination angle between the plunger pumps and the rotation shaft of the synchronization motor.

### Claim 3 (depends on 1)

The blood purification device according to claim 1, wherein
a rotation radius of the drive joint on the used dialysate suction side is made larger than a rotation radius of the drive joint on the fresh dialysate delivery side, and
a stroke of the plunger pump on the used dialysate suction side is made variable.

### Claim 4 (depends on 1)

The blood purification device according to claim 1, wherein the plunger pump is a valveless plunger pump.

### Claim 5 (depends on 1)

The blood purification device according to claim 1, wherein another pair of plunger pumps having a 180° shifted phase are disposed in parallel to the dialysate line.

### Claim 6

A blood purification device comprising:
a blood purifier;
a blood circuit connected to the blood purifier;
a blood pump for generating blood flow in the blood circuit;
a synchronization motor;
drive joints which rotate by driving force given from the synchronization motor;
a dialysate line having a fresh dialysate supply line and a used dialysate discharge line each connected to the blood purifier; and
plunger pumps provided, respectively, in the fresh dialysate supply line and the used dialysate discharge line so as to form one pair, wherein:
the plunger pump provided in the fresh dialysate supply line and the plunger pump provided in the used dialysate discharge line are synchronized so that delivery of a fresh dialysate by the plunger pump provided in the fresh dialysate supply line and suction of a used dialysate by the plunger pump provided in the used dialysate discharge line are simultaneously performed, and
the pair of plunger pumps are disposed in a mirrored, symmetrical manner with respect to a plane orthogonal to a rotation shaft of the synchronization motor and are connected to the synchronization motor by the drive joints.

### Claim 7

A blood purification device comprising:
a blood purifier;
a blood circuit connected to the blood purifier;
a blood pump for generating blood flow in the blood circuit;
a synchronization motor;
drive joints which rotate by driving force given from the synchronization motor;
a dialysate line having a fresh dialysate supply line and a used dialysate discharge line each connected to the blood purifier; and
plunger pumps provided, respectively, in the fresh dialysate supply line and the used dialysate discharge line so as to form one pair, wherein:
the plunger pump provided in the fresh dialysate supply line and the plunger pump provided in the used dialysate discharge line are synchronized so that delivery of a fresh dialysate by the plunger pump provided in the fresh dialysate supply line and suction of a used dialysate by the plunger pump provided in the used dialysate discharge line are simultaneously performed,
a stroke of at least one of the plunger pumps individually provided in the fresh dialysate supply line and the used dialysate discharge line is variable,
a stroke of the plunger pump provided in the used dialysate discharge line is variable, and
a rotation radius of the drive joint on a used dialysate suction side is larger than a rotation radius of a drive joint on a fresh dialysate delivery side.

### Claim 8 (depends on 7)

The blood purification device according to claim 7, wherein in the plunger pump in which the stroke is variable of the pair of plunger pumps, an inclination angle of a shaft of a plunger with respect to the rotation shaft of a synchronization motor is adjustable.

### Claim 9 (depends on 7)

The blood purification device according to claim 7 further comprising:
an angle adjustment motor varying the inclination angle of the shaft of the plunger.

### Claim 10

A method for passing a dialysate to a blood purifier using a first plunger pump and a second plunger pump, respectively provided in a fresh dialysate supply line and a used dialysate discharge line, each of the fresh dialysate supply line and the used dialysate discharge line connected to the blood purifier, the method comprising:
a delivery step of delivering a fresh dialysate to the blood purifier through the fresh dialysate supply line by transmitting rotary drive to the first plunger pump from the synchronization motor; and
a suction step of sucking a used dialysate from the blood purifier through the used dialysate discharge line by transmitting rotary drive to the second plunger pump from a synchronization motor, wherein
the delivery step and the step are simultaneously performed in a synchronized manner.

### Claim 11 (depends on 10)

The method for passing a dialysate to a blood purifier according to claim 10, wherein the transmission of the drive of the synchronization motor to the first plunger pump in the delivery step and the transmission of the drive of the synchronization motor to the second plunger pump in the suction step are performed at a 180° shifted phase.

### Claim 12 (depends on 10)

The method for passing a dialysate to a blood purifier according to claim 10, wherein a stroke length of the first plunger pump in the delivery step and a stroke length of the second plunger pump in the suction step are different.

### Claim 13

A blood purification device comprising:
a blood purifier;
a blood circuit connected to the blood purifier;
a synchronization motor;
a first drive joint which rotates by driving force given from the synchronization motor;
a blood pump for generating blood flow in the blood circuit;
a dialysate line having (i) a fresh dialysate supply line coupled to a fresh dialysate tank and to the blood purifier, and (ii) a used dialysate discharge line coupled to a waste dialysate tank and to the blood purifier, each of the fresh dialysate supply line and the used dialysate discharge line divided into a respective pair of parallel lines for a respective length; and
a first pair of plunger pumps provided, respectively, in each of the parallel fresh dialysate supply lines, and a second pair of plunger pumps provided, respectively, in each of the parallel used dialysate discharge lines, wherein:
the first pair of plunger pumps alternately and continuously perform delivery of a fresh dialysate by one plunger pump of the first pair of plunger pumps and delivery of a fresh dialysate by the other plunger pump of the first pair of plunger pumps,
the second pair of plunger pumps alternately and continuously perform suction of a used dialysate by one plunger pump of the second pair of plunger pumps and suction of a used dialysate by the other plunger pump of the second pair of plunger pumps,
the first pair of plunger pumps and the second pair of plunger pumps are synchronized so that delivery of a fresh dialysate by the first pair of plunger pumps and suction of a used dialysate by the second pair of plunger pumps are simultaneously performed, and
the first pair of plunger pumps are disposed in a mirrored, symmetrical manner with respect to a plane orthogonal to a rotation shaft of the synchronization motor and are connected to the synchronization motor by the first drive joint.

### Claim 14 (depends on 13)

The blood purification device according to claim 13 further comprising:
a synchronization motor; and
a second drive joint which rotates by driving force given from the synchronization motor, wherein
the second pair of plunger pumps are disposed in a mirrored, symmetrical manner with respect to a plane orthogonal to the rotation shaft of the synchronization motor and are connected to the synchronization motor by the second drive joint.

### Claim 15 (depends on 14)

The blood purification device according to claim 14, wherein the first pair of plunger pumps and the second pair of plunger pumps are disposed in a mirrored, symmetrical manner with respect to a plane orthogonal to the rotation shaft of the synchronization motor.