# US 10,307,507 B2 · Hydrocolloid wound dressings with increased WVTR > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,507 B2 - Document ID: US10307507B2 - Status: Granted - Kind: B2 - Application number: 14/775,084 - Filed: 2014-03-11 - Published: 2016-01-21 - Granted: 2019-06-04 - Earliest claimed: 2013-03-14 - Assignees: 3M Innovative Properties Company - Applicants: 3M Innovative Properties Company - Inventors: Herbert C. Chiou; Hae-Seung Lee - Web page: https://patentgrep.com/patent/US10307507B2 ## CPC - A61L 15/585: {Mixtures of macromolecular compounds} - A61L 15/225: {Mixtures of macromolecular compounds} - A61L 15/60: Liquid-swellable gel-forming materials, e.g. super-absorbents - A61L 24/0031: {Hydrogels or hydrocolloids} - A61L 24/043: {Mixtures of macromolecular materials} - A61P 17/00: Drugs for dermatological disorders - C08L 1/286: {substituted with acid radicals, e.g. carboxymethyl cellulose [CMC] (C08L1/282 takes precedence)} - C08L 9/00: Compositions of homopolymers or copolymers of conjugated diene hydrocarbons - C08L 87/00: Compositions of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds - C09J 123/20: having four to nine carbon atoms - C09J 147/00: Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds; Adhesives based on derivatives of such polymers (C09J145/00 takes precedence; based on conjugated diene rubbers C09J109/00 - C09J121/00) - C09J 179/02: Polyamines - A61L 2400/14: Adhesives for ostomy devices - A61L 2420/06: Coatings containing a mixture of two or more compounds - C08G 81/025: {containing polyether sequences} - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06) - C09J: ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES (preparation of glue or gelatine C09H) - C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ## Abstract Hydrocolloid compositions, wound dressings, methods of using such compositions and such wound dressings, and methods of forming such hydrocolloid compositions, wherein the hydrocolloid compositions include a hydrophobic, unsaturated, elastomeric polymer; a hydrocolloid absorbent; and a hydrophilic polymer including an unsaturated polymer backbone having polyalkylene ether groups bonded thereto. ## Claims ### Claim 1 A hydrocolloid composition comprising: a hydrophobic, unsaturated, elastomeric polymer; a hydrocolloid absorbent; and a hydrophilic polymer comprising an unsaturated polymer backbone having polyalkylene ether pendant groups bonded thereto, wherein the polyalkylene ether groups are derived from a hydrophilic polyalkylene oxide-containing compound and wherein the hydrophilic polyalkylene oxide-containing compound comprises ethylene oxide units and optionally co-polymerized propylene oxide units, wherein the unsaturated polymer backbone comprises one of epoxidized polyubutadiene, polyubutadiene and polyisoprene, and wherein the hydrophilic polymer is present in an amount that increases the water vapor transmission rate (WVTR) of the hydrocolloid composition relative to the same hydrocolloid composition without the hydrophilic polymer. ### Claim 2 (depends on 1) The hydrocolloid composition of claim 1 wherein the hydrophobic and hydrophilic polymers are crosslinked to provide the composition with a crosslinked matrix comprising partial unsaturation. ### Claim 3 (depends on 2) The hydrocolloid composition of claim 2 which is in the form of an adhesive. ### Claim 4 (depends on 3) The hydrocolloid composition of claim 3 which is in the form of a pressure sensitive adhesive. ### Claim 5 (depends on 1) The hydrocolloid composition of claim 1 wherein the hydrophobic, unsaturated, elastomeric polymer is present in an amount of 20-50 wt-%, based on the total weight of the composition. ### Claim 6 (depends on 1) The hydrocolloid composition of claim 1 wherein the hydrophilic polymer is present in an amount of 0.5-20 wt-%, based on the total weight of the composition. ### Claim 7 (depends on 1) The hydrocolloid composition of claim 1 wherein the hydrocolloid absorbent is present in an amount of 5-60 wt-%, based on the total weight of the composition. ### Claim 8 (depends on 1) The hydrocolloid composition of claim 1 wherein the polyalkylene ether groups comprise at least 70 wt-% ethylene oxide units, based on the total weight of a polyalkylene oxide-containing compound from which the hydrophilic polymer is derived. ### Claim 9 (depends on 1) The hydrocolloid composition of claim 1 wherein the hydrophilic polymer comprises 20-95 wt-% hydrophobic polymer backbone and 5-80 wt-% hydrophilic polyalkylene ether groups bonded thereto, based on the total weight of the hydrophilic polymer. ### Claim 10 (depends on 1) The hydrocolloid composition of claim 1 wherein the hydrophilic polymer is derived from an optionally functionalized hydrophobic, unsaturated, elastomeric polymer and a hydrophilic polyalkylene oxide-containing compound. ### Claim 11 (depends on 1) The hydrocolloid composition of claim 1 comprising: a hydrophobic, unsaturated, elastomeric homopolymer; a tackifier; a hydrocolloid absorbent selected from the group of a natural hydrocolloid, a semi-synthetic hydrocolloid, a synthetic hydrocolloid, and combinations thereof; and a hydrophilic polymer comprising an unsaturated polymer backbone having polyalkylene ether groups bonded thereto; wherein the hydrophobic and hydrophilic polymers are crosslinked by 5-200 kGy gamma radiation to provide an adhesive composition with a crosslinked matrix. ### Claim 12 (depends on 1) The hydrocolloid composition of claim 1 wherein the hydrophilic polymer is present in an amount that increases the WVTR of the hydrocolloid composition by at least 50% relative to the same hydrocolloid composition without the hydrophilic polymer. ### Claim 13 A hydrocolloid composition comprising: 20-50 wt-% of a hydrophobic, unsaturated, elastomeric homopolymer; 5-60 wt-% of a hydrocolloid absorbent; and 0.5-20 wt-% of a hydrophilic polymer comprising an unsaturated polymer backbone having polyalkylene ether pendant groups bonded thereto; wherein the polyalkylene ether groups are derived from a hydrophilic polyalkylene oxide-containing compound and wherein the hydrophilic polyalkylene oxide-containing compound comprises ethylene oxide units and optionally co-polymerized propylene oxide units, wherein the unsaturated polymer backbone comprises one of epoxidized polyubutadiene, polyubutadiene and polyisoprene, wherein the hydrocolloid composition is in the form of a pressure sensitive adhesive; and wherein the hydrophilic polymer is present in an amount that increases the WVTR of the hydrocolloid composition relative to the same hydrocolloid composition without the hydrophilic polymer. ### Claim 14 (depends on 1) A wound dressing comprising the hydrocolloid composition of claim 1 coated on a surface of a moisture vapor permeable backing. ### Claim 15 (depends on 14) The wound dressing of claim 14 wherein the backing further comprises a release coating coated on the surface of the backing opposite the surface coated with the hydrocolloid composition. ### Claim 16 (depends on 14) The wound dressing of claim 14 wherein the backing extends beyond the periphery of the hydrocolloid composition coating on all sides, and wherein at least a portion of the extended backing surface is coated with a second pressure sensitive adhesive. ### Claim 17 A method of forming a hydrocolloid composition, the method comprising: compounding a mixture comprising: a hydrophobic, unsaturated, elastomeric polymer; a hydrocolloid absorbent; and a hydrophilic polymer comprising an unsaturated polymer backbone having polyalkylene ether pendant groups bonded thereto, wherein the polyalkylene ether groups are derived from a hydrophilic polyalkylene oxide-containing compound, wherein the hydrophilic polyalkylene oxide-containing compound comprises ethylene oxide units and optionally co-polymerized propylene oxide units, and wherein the unsaturated polymer backbone comprises one of epoxidized polyubutadiene, polyubutadiene and polyisoprene; and irradiating the mixture with radiation sufficient to crosslink the hydrophobic and hydrophilic polymers and form a composition with a crosslinked matrix comprising partial unsaturation. ### Claim 18 (depends on 17) The method of claim 17 wherein irradiating the mixture comprises exposing the mixture to a dose of radiation from 5 kGy to 200 kGy. ### Claim 19 (depends on 17) The method of claim 17 wherein the mixture comprises: a hydrophobic, unsaturated, elastomeric homopolymer; a tackifier; a hydrocolloid absorbent selected from the group of a natural hydrocolloid, a semi-synthetic hydrocolloid, a synthetic hydrocolloid, and combinations thereof; and a hydrophilic polymer comprising an unsaturated polymer backbone having polyalkylene ether groups bonded thereto.