# US 10,307,498 B2 · Cleaning and disinfecting composition

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- Number: US 10,307,498 B2
- Document ID: US10307498B2
- Status: Granted
- Kind: B2
- Application number: 15/485,525
- Filed: 2017-04-12
- Published: 2017-08-03
- Granted: 2019-06-04
- Earliest claimed: 2015-11-10
- Assignees: American Sterilizer Company
- Applicants: American Sterilizer Company
- Inventors: Phillip P. Franciskovich; Donald G. Rosenhamer; Kathleen A. Fix
- Web page: https://patentgrep.com/patent/US10307498B2

## CPC

- A61L 2/18: Liquid substances
- A01N 37/02: Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A01N 37/16: containing the group [IMAGE cpc-sch-A01N-0934.gif]; Thio analogues thereof
- A01N 59/00: Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N 59/02: Sulfur; Selenium; Tellurium; Compounds thereof
- A61B 1/005: Flexible endoscopes
- A61B 1/125: {using fluid circuits}
- A61L 2/186: Peroxide solutions
- B08B 3/08: the liquid having chemical or dissolving effect
- C11D 1/66: Non-ionic compounds {(C11D1/002, C11D1/004, C11D1/008 take precedence)}
- C11D 1/662: {Carbohydrates or derivatives}
- C11D 1/72: Ethers of polyoxyalkylene glycols
- C11D 1/722: Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; {Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups (C11D1/721 takes precedence)}
- C11D 1/75: Amino oxides
- C11D 1/88: Ampholytes; Electroneutral compounds {(C11D1/002, C11D1/004, C11D1/008 take precedence)}
- C11D 1/90: Betaines
- C11D 3/0073: {Anticorrosion compositions}
- C11D 3/046: {Salts}
- C11D 3/2068: {Ethers}
- C11D 3/2075: {Carboxylic acids-salts thereof}
- C11D 3/2082: {Polycarboxylic acids-salts thereof}
- C11D 3/2086: {Hydroxy carboxylic acids-salts thereof}
- C11D 3/225: {etherified, e.g. CMC}
- C11D 3/28: Heterocyclic compounds containing nitrogen in the ring
- C11D 3/30: Amines; Substituted amines {; Quaternized amines}
- C11D 3/33: Amino carboxylic acids
- C11D 3/361: {Phosphonates, phosphinates or phosphonites}
- C11D 3/364: {containing nitrogen}
- C11D 3/365: {containing carboxyl groups}
- C11D 3/3707: {Polyethers, e.g. polyalkyleneoxides}
- C11D 3/38618: {Protease or amylase in liquid compositions only}
- C11D 3/38627: {containing lipase}
- C11D 3/38636: {containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase}
- C11D 3/3947: {Liquid compositions}
- C11D 3/48: Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
- C11D 7/10: Salts
- C11D 7/263: {Ethers}
- C11D 7/265: {Carboxylic acids or salts thereof}
- C11D 7/3218: {Alkanolamines or alkanolimines}
- C11D 7/3245: {Aminoacids}
- C11D 7/3281: {Heterocyclic compounds}
- C11D 7/36: containing phosphorus
- A61L 2103/15: Laboratory, medical or dentistry appliances, e.g. catheters or sharps
- A61L 2202/17: Combination with washing or cleaning means
- B08B 3/04: Cleaning involving contact with liquid
- C11D 3/2041: {Dihydric alcohols}
- C11D 3/2044: {linear}
- C11D 3/222: {Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin}
- C11D 3/3945: {Organic per-compounds (C11D3/3902 takes precedence)}
- C11D 2111/20: Industrial or commercial equipment, e.g. reactors, tubes or engines
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- B08B: CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- C11D: DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL

## Abstract

The disclosed invention relates to a two-part liquid composition for cleaning and disinfecting a substrate, comprising: (A) a disinfectant medium comprising peracetic acid; and (B) a supplemental medium comprising a non-enzymatic cleaner, a corrosion inhibitor, and a chelator. The supplemental medium (B) may further comprise an enzymatic cleaner, a surfactant, a buffer, a pH modifier, or a mixture of two or more thereof. The substrate may be a medical device, for example, an endoscope.

## Claims

### Claim 1

A process for cleaning and disinfecting a substrate contaminated with living microorganisms using a two-part liquid composition comprising components (A) and (B), wherein component (A) comprises a disinfectant medium comprising from about 5% to about 60% by weight of the disinfectant medium of peracetic acid, acetic acid, hydrogen peroxide and from about 0.5% to about 2% by weight of the disinfectant medium of sulfuric acid, wherein the pH of the disinfectant medium is from about 1 to about 8; and component (B) comprises a supplemental medium comprising an enzymatic cleaner, a non-enzymatic cleaner, a corrosion inhibitor and a chelator; wherein the non-enzymatic cleaner comprises an alkanol amine, a polyalkylene glycol, an alkyl diproprionate, an alkyl dialkylamine oxide, or a mixture of two or more thereof, wherein the volumetric ratio of (a) to (B) is in the range from about 5:1 to 1:5; the process comprising: contacting the substrate with the supplemental medium (B) and the disinfectant medium (A) to clean and disinfect the substrate.

### Claim 2 (depends on 1)

The process of claim 1 wherein the substrate is made of a material comprising brass, copper, aluminum, stainless steel, carbon steel, plastic, glass, or a combination of two or more thereof.

### Claim 3 (depends on 1)

The process of claim 1 wherein the substrate comprises a medical, dental, pharmaceutical, veterinary or mortuary instrument or device.

### Claim 4 (depends on 1)

The process of claim 1 wherein the substrate comprises an endoscope.

### Claim 5 (depends on 4)

The process of claim 4 wherein the endoscope comprises a rigid endoscope.

### Claim 6 (depends on 4)

The process of claim 4 wherein the endoscope comprises a flexible endoscope.

### Claim 7 (depends on 1)

The process of claim 1 wherein the process is conducted at a temperature in the range from about 15° C. to about 60° C.

### Claim 8 (depends on 1)

The process of claim 1 wherein the substrate is cleaned and sterilized.

### Claim 9 (depends on 1)

The process of claim 1 wherein supplemental medium (B) further comprises a surfactant, a buffer, a pH modifier or a mixture of two or more thereof.

### Claim 10 (depends on 1)

The process of claim 1 wherein the alkanol amine comprises monoethanol amine, diethanol amine, triethanol amine, or a mixture of two or more thereof.

### Claim 11 (depends on 1)

The process of claim 1 wherein the polyalkylene glycol comprises polyethylene glycol, polypropylene glycol, or a mixture thereof.

### Claim 12 (depends on 1)

The process of claim 1 wherein the polyalkylene glycol comprises polyethylene glycol.

### Claim 13 (depends on 1)

The process of claim 1 wherein the alkyl diproprionate comprises an octyl diproprionate.

### Claim 14 (depends on 1)

The process of claim 1 wherein the alkyl dialkylamine oxide comprises octyl dimethylamine oxide.

### Claim 15 (depends on 1)

The process of claim 1 wherein the supplemental medium (B) comprises monoethanolamine, triethanolamine, octyldimethylamine oxide, polyalkylene glycol, octyl dipropionate, or a mixture of two or more thereof.

### Claim 16 (depends on 1)

The process of claim 1 wherein the supplemental medium (B) comprises from about 0.1 to about 25% by weight of the non-enzymatic cleaner.

### Claim 17 (depends on 1)

The process of claim 1 wherein the enzymatic cleaner comprises a lipase, an amylase, a carbohydrase, a protease, or a mixture of two or more thereof.

### Claim 18 (depends on 1)

The process of claim 1 wherein the enzymatic cleaner comprises a proteolytic enzyme.

### Claim 19 (depends on 1)

The process of claim 1 wherein the enzymatic cleaner comprises a subtilisin.

### Claim 20 (depends on 1)

The process of claim 1 wherein the enzymatic cleaner comprises a protein hydrolyzing enzyme, a protein digesting enzyme, or a mixture thereof.

### Claim 21 (depends on 1)

The process of claim 1 wherein the supplemental medium (B) comprises from about 0.2% to about 25% by weight of the enzymatic cleaner.

### Claim 22 (depends on 9)

The process of claim 9 wherein the buffer comprises an alkali metal phosphate, an alkali metal carbonate, or a mixture thereof.

### Claim 23 (depends on 9)

The process of claim 9 wherein the supplemental medium (B) comprises up to about 15% by weight of the buffer.

### Claim 24 (depends on 1)

The process of claim 1 wherein the corrosion inhibitor comprises benzotriazole, tolyltriazole, sodium salt of benzotriazole, sodium salt of tolyltriazole, aminotrimethylene phosphonic acid, octyl betaine, a carboxylic acid, ethanolamine, phosphonobutane tricarboxylic acid, or a mixture of two or more thereof.

### Claim 25 (depends on 1)

The process of claim 1 wherein the supplemental medium (B) comprises from about 0.1% to about 10% by weight of the corrosion inhibitor.

### Claim 26 (depends on 1)

The process of claim 1 wherein the chelator comprises ethylenediaminetetraacetic acid, hydroxyethylidenediphosphonic acid, sodium salt of ethylenediaminetetraacetic acid, sodium salt of hydroxyethylidenediphosphonic acid, aminotrimethylene phosphonic acid, a polycarboxylic acid, tetrasodium iminodisuccinate, carboxymethyl inulin, sodium borate, methylglycine diacetic acid, or a mixture of two or more thereof.

### Claim 27 (depends on 1)

The process of claim 1 wherein the chelator comprises citric acid.

### Claim 28 (depends on 1)

The process of claim 1 wherein the supplemental medium (B) comprises from about 0.1 to about 70% by weight of the chelator.

### Claim 29 (depends on 9)

The process of claim 9 wherein the buffer comprises an amine, a carboxylic acid, a phosphate, a carbonate, or a mixture of two or more thereof.

### Claim 30 (depends on 9)

The process of claim 9 wherein the supplemental medium (B) comprises from about 1 to about 15% by weight of the buffer.

### Claim 31 (depends on 9)

The process of claim 9 wherein the surfactant comprises a detergent, wetting agent, emulsifier, foaming agent and/or dispersant.

### Claim 32 (depends on 9)

The process of claim 9 wherein the surfactant comprises a compound that contains at least one hydrophobic group and at least one hydrophilic group.

### Claim 33 (depends on 9)

The process of claim 9 wherein the surfactant comprises a water insoluble component and a water soluble component.

### Claim 34 (depends on 9)

The process of claim 9 wherein the surfactant comprises an anionic, cationic, zwitterionic and/or nonionic compound.

### Claim 35 (depends on 9)

The process of claim 9 wherein the surfactant comprises one or more polyalkylene glycol ethers, alkylarylsulfonates, amine oxides, poly(oxyalkylene) compounds, block copolymers comprising alkylene oxide repeat units, carboxylated alcohol ethoxylates, ethoxylated alkyl phenols, ethoxylated amines, ethoxylated amides, oxiranes, ethoxylated fatty acids, ethoxylated fatty esters, ethoxylated oils, fatty esters, fatty acid amides, glycerol esters, glycol esters, sorbitan esters, imidazoline and/or derivatives thereof, lecithin and/or derivatives thereof, lignin and/or derivatives thereof, glycerides and/or derivatives thereof, olefin sulfonates, phosphate esters and/or derivatives thereof, propoxylated and/or ethoxylated fatty acids and/or alcohols, alkyl phenols, sorbitan and/or derivatives thereof, sucrose esters and/or derivatives thereof, sulfates and/or alcohols and/or ethoxylated alcohols of fatty esters, sulfonates of dodecyl and/or tridecyl benzenes, condensed naphthalenes, sulfosuccinates and/or derivatives thereof, tridecyl and/or dodecyl benzene sulfonic acids, octyl betaine, or a mixture of two or more thereof.

### Claim 36 (depends on 9)

The process of claim 9 wherein the concentration of the surfactant in the supplemental medium (B) is in the range up to about 25% by weight.

### Claim 37 (depends on 1)

The process of claim 1 wherein the supplemental medium (B) further comprises one or more scale inhibitors, preservatives, defloculents, suspension agents, metal passivators, thickening agents, antifoam agents, foam enhancing agents, oil removal agents, sequestration agents, rheology modification agents, penetration agents, solubility agents, rinse aids, or a mixture of two or more thereof.

### Claim 38 (depends on 1)

The process of claim 1 wherein the supplemental medium (B) has a pH in the range from about 6 to about 14.

### Claim 39 (depends on 1)

The process of claim 1 wherein the disinfectant medium (A) is diluted with water, the volumetric ratio of water to the disinfectant medium (A) being up to about 1000:1.

### Claim 40 (depends on 1)

The process of claim 1 wherein the supplemental medium (B) is diluted with water, the volumetric ratio of water to the supplemental medium (B) being up to about 100:1.