# US 10,307,494 B2 · Curable composition and method for implantation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,494 B2 - Document ID: US10307494B2 - Status: Granted - Kind: B2 - Application number: 15/195,116 - Filed: 2016-06-28 - Published: 2017-12-28 - Granted: 2019-06-04 - Earliest claimed: 2016-06-28 - Assignees: National Guard Health Affairs; King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center - Applicants: National Guard Health Affairs; King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center - Inventors: Mamdooh Alqathami - Web page: https://patentgrep.com/patent/US10307494B2 ## CPC - A61K 49/1818: {particles, e.g. uncoated or non-functionalised microparticles or nanoparticles} - A61K 49/12: Macromolecular compounds - A61K 51/06: Macromolecular compounds {, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules (peptides, proteins, polyamino acids A61K51/08; antibodies A61K51/10)} - A61K 51/1213: {Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature} - A61K 51/1282: {Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract A biocompatible curable composition and a method of detecting a border of a tumor, a tissue of interest, or both including injecting the biocompatible curable composition and contacting the border of a tumor or a tissue, the biocompatible curable composition crosslinks to form a three-dimensional cured nanocomposite, and imaging the three-dimensional (3D) cured nanocomposite, and imaging the 3D cured nanocomposite by at least one of MRI, CT, ultrasound, and X-ray, to detect the border of the tumor or the tissue of interest or track tumor motion during radiotherapy treatment. The biocompatible curable composition comprising an organic polymer having a hydrolysable functional group, a metallic nanoparticle, and a polar or a non-polar solvent. A brachytherapy strand consisting of a biocompatible curable composition and a radio-isotope seed. The biocompatible curable composition is shaped into an elongated cylinder and forms a 3D cured nanocomposite with a radio-isotope seed embedded. ## Claims ### Claim 1 A biocompatible curable composition comprising: an organic polymer comprising at least one hydrolysable functional group selected from the group consisting of a silane and an isocyanate; a solvent selected from the group consisting of hexane and toluene; and a metallic nanoparticle, wherein the metallic nanoparticle is at least one of a manganese-based nanoparticle and a gadolinium-based nanoparticle, and is dispersed in the organic polymer and the solvent at a weight percent relative to the total weight of the biocompatible curable composition of 0.1% to 30%; wherein the biocompatible curable composition crosslinks upon contact with an aqueous solution or moisture to form a three-dimensional cured nanocomposite. ### Claim 2 (depends on 1) The biocompatible curable composition of claim 1, wherein the metallic nanoparticle has at least one dimension of 1 nm-150 nm. ### Claim 3 (depends on 1) The biocompatible curable composition of claim 1, wherein a weight percent of the metallic nanoparticle is 2.5-30 wt. % relative to the total weight of the biocompatible curable composition. ### Claim 4 (depends on 1) The biocompatible curable composition of claim 1, wherein the metallic nanoparticle is modified by at least one of an organic ligand, a coupling agent, and a surfactant. ### Claim 5 (depends on 1) The biocompatible curable composition of claim 1, wherein the biocompatible curable composition and the three-dimensional cured nanocomposite are detectable by at least one imaging modality selected from the group consisting of magnetic resonance imaging, computed tomography, ultrasound, and X-ray. ### Claim 6 (depends on 1) The biocompatible curable composition of claim 1, further comprising a second nanoparticle comprising at least one of a paramagnetic element, a radio-isotope, a radio-opaque element, and a radio-opaque compound. ### Claim 7 (depends on 6) The biocompatible curable composition of claim 6, wherein the second nanoparticle is a radio-isotope seed. ### Claim 8 (depends on 1) The biocompatible curable composition of claim 1, wherein the three-dimensional cured nanocomposite is an elastomeric three-dimensional cured nanocomposite. ### Claim 9 (depends on 8) The biocompatible curable composition of claim 8, wherein the elastomeric three-dimensional cured nanocomposite is configured to crosslink a biological tissue via the hydrolysable functional group. ### Claim 10 (depends on 9) The biocompatible curable composition of claim 9, wherein the elastomeric three-dimensional cured nanocomposite has a Shore durometer hardness of 5 to 40 on a Shore durometer Type A scale, or a Shore durometer hardness of 40-100 on a Shore durometer Type OO scale. ### Claim 11 (depends on 1) The biocompatible curable composition of claim 1, wherein the organic polymer comprises at least one reacted form of a tetraethoxysilane, a methyltrimethoxysilane, a methyltriethoxysilane, an isobutyltrimethoxysilane, a phenyl trimethoxysilane, and a n-octyltriethoxysilane. ### Claim 12 A brachytherapy strand consisting of: a biocompatible curable composition; and a radio-isotope seed; wherein the biocompatible curable composition comprises: an organic polymer comprising at least one hydrolysable or non-hydrolysable functional group selected from a silane and an isocyanate; a solvent selected from the group consisting of hexane and toluene; and a metallic nanoparticle, wherein the metallic nanoparticle is at least one of a manganese-based nanoparticle and a gadolinium-based nanoparticle, is dispersed in the organic polymer and the solvent at a weight percent relative to the total weight of the biocompatible curable composition of 0.1% to 30%, and is visible by MRI; and wherein the biocompatible curable composition is in the form of an elongated cylinder and crosslinks upon contact with an aqueous solution or moisture to form a three-dimensional cured nanocomposite having the radio-isotope seed embedded in the three-dimensional cured nanocomposite. ### Claim 13 A method of detecting a border of a tumor, a tissue of interest, or both comprising: injecting a biocompatible curable composition into a subject and contacting the biocompatible curable composition with the border of a tumor, a tissue of interest, or both, wherein the biocompatible curable composition crosslinks upon exposure to an aqueous solution or moisture to form a three-dimensional cured nanocomposite, which is covalently bonded to the border of the tumor, the tissue of interest, or both; and imaging the three-dimensional cured nanocomposite by at least one of magnetic resonance imaging, computed tomography, ultrasound, and X-ray, wherein the border of the tumor, the tissue of interest, or both is detected; wherein the biocompatible curable composition comprises: an organic polymer comprising at least one hydrolysable functional group selected from the group consisting of a silane and an isocyanate; a solvent selected from the group consisting of hexane and toluene; and a metallic nanoparticle, wherein the metallic nanoparticle is at least one of a manganese-based nanoparticle and a gadolinium-based nanoparticle, and is dispersed in the organic polymer and the solvent at a weight percent relative to the total weight of the biocompatible curable composition of 0.1% to 30%. ### Claim 14 (depends on 13) The method of claim 13, wherein the metallic nanoparticle has at least one dimension of 1 nm-150 nm. ### Claim 15 (depends on 13) The method of claim 13, wherein the metallic nanoparticle is modified by at least one of an organic ligand, a coupling agent, and a surfactant. ### Claim 16 (depends on 13) The method of claim 13, wherein the three-dimensional cured nanocomposite is an elastomeric three-dimensional cured nanocomposite. ### Claim 17 (depends on 13) The method of claim 13, wherein the imaging comprises registering the image of the three-dimensional cured nanocomposite at the border of a tumor, a tissue of interest, or both. ### Claim 18 (depends on 13) The method of claim 13, further comprising injecting a radio-isotope seed into the three-dimensional cured nanocomposite after the injecting of the biocompatible curable composition or after the imaging. ### Claim 19 (depends on 13) The method of claim 13, wherein the biocompatible curable composition is employed in real-time target motion tracking in radiotherapy.