# US 10,307,453 B2 · Method for extracting stilbene compounds

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,307,453 B2
- Document ID: US10307453B2
- Status: Granted
- Kind: B2
- Application number: 15/527,933
- Filed: 2015-12-30
- Published: 2018-11-01
- Granted: 2019-06-04
- Earliest claimed: 2015-01-08
- Assignees: Kpc Pharmaceuticals, Inc.
- Applicants: Kpc Pharmaceuticals, Inc
- Inventors: Yunqi Gong; Jinxin Chen; Fang Fang
- Web page: https://patentgrep.com/patent/US10307453B2

## CPC

- A61K 36/708: Rheum (rhubarb)
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- B01D 11/0288: {Applications, solvents}
- A61K 2236/00: Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K 2236/33: involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K 2236/331: using water, e.g. cold water, infusion, tea, steam distillation or decoction
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)

## Abstract

A method for extracting stilbene compounds comprises the following steps: grinding a medicinal material rich in stilbene compounds such as rheum officinale; extracting the medicinal material with a herbal flash extractor for one to four times, 5-20 minutes each time; filtering and combining filtrate and concentrating the filtrate to dryness; the proportion of the medicinal material to a solvent being 1 g: 10 ml-1 g:15 ml.

## Claims

### Claim 1

A method for extracting stilbenoid compounds, comprising:
(a) providing a medicinal material rich in stilbenoid compounds as a raw material,
(b) extracting the medicinal material with a flash extractor one or more times,
(c) filtering the extract made in step (b) after each extraction,
(d) combining the filtrates when there are two or more filtrates and
(e) drying the filtrate or combined filtrates to concentrate the stilbenoid compounds.

### Claim 2 (depends on 1)

The method according to claim 1, comprising:
(a) providing a medicinal material rich in stilbenoid compounds as a raw material,
(b) pulverizing the medicinal material,
(c) adding a solvent to the pulverized material,
(d) extracting the pulverized material one to four times with a flash extractor for 5-20 minutes each time,
(e) filtering the extract made in step (d) after each extraction,
(f) combining the filtrates when there are two or more filtrates and
(g) drying the filtrate or combined filtrates to concentrate the stilbenoid compounds.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the medicinal material rich in stilbenoid compounds is one of Rheum lhasaense A. J. Li et P. K. Hsiao, Rheum hotaoense C. Y Cheng et Kao, Rheum australe D. Don and Rheum likiangense Sam., or a mixture thereof.

### Claim 4 (depends on 2)

The method according to claim 2, wherein the solvent is water, methanol, ethanol, acetone or a mixture thereof, wherein, in the mixture, the solvents may be in any ratio.

### Claim 5 (depends on 2)

The method according to claim 2, wherein the solvent is methanol, ethanol or acetone.

### Claim 6 (depends on 2)

The method according to claim 2, wherein the temperature of the solvent is 20° C. to 40° C.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the extracting is performed one to three times.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the extracting is performed for 5-10 minutes each time.

### Claim 9 (depends on 2)

The method according to claim 2, wherein the weight-to-volume ratio of the medicinal material to the solvent is 1:10 to 1:15.