# US 10,307,438 B2 · Methods of treating hepatitis E viral infection

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- Number: US 10,307,438 B2
- Document ID: US10307438B2
- Status: Granted
- Kind: B2
- Application number: 15/611,307
- Filed: 2017-06-01
- Published: 2017-12-07
- Granted: 2019-06-04
- Earliest claimed: 2016-06-03
- Assignees: Gilead Sciences, Inc.
- Applicants: Gilead Sciences, Inc.
- Inventors: Norbert W. Bischofberger; John G. McHutchison
- Web page: https://patentgrep.com/patent/US10307438B2

## CPC

- A61K 31/7072: having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A61K 31/7056: containing five-membered rings with nitrogen as a ring hetero atom
- A61P 31/14: for RNA viruses
- A61K 31/706: containing six-membered rings with nitrogen as a ring hetero atom
- A61K 31/7064: containing condensed or non-condensed pyrimidines
- A61K 31/7068: having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed herein are methods of treating a hepatitis E viral infection comprising administering to a human subject in need thereof a therapeutically effective amount of the compound sofosbuvir, also known as (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate. Some methods further comprise concomitantly administering ribavirin to the subject. In some methods, the treatment is ribavirin-free. In some methods, the subject is immunocompromised. In some methods, the subject is pregnant.

## Claims

### Claim 1

A method of treating a Hepatitis E viral infection comprising administering to a human subject in need thereof a therapeutically effective amount of the compound of Formula (IA)
wherein the subject is pregnant.