# US 10,307,435 B2 · Exercise performance enhancers

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- Number: US 10,307,435 B2
- Document ID: US10307435B2
- Status: Granted
- Kind: B2
- Application number: 15/381,877
- Filed: 2016-12-16
- Published: 2017-06-22
- Granted: 2019-06-04
- Earliest claimed: 2015-12-16
- Assignees: University of Georgia Research Foundation, Inc.
- Applicants: University of Georgia Research Foundation, Inc.
- Inventors: Jamie A. Cooper
- Web page: https://patentgrep.com/patent/US10307435B2

## CPC

- A61K 31/7016: Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032)
- A23L 33/125: containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates (indigestible substances A23L33/21)
- A61K 9/006: {Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays}
- A61K 9/7007: {Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence)}
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)

## Abstract

Disclosed are compositions, articles, and method for enhancing exercise performance in a subject. The method involves contacting the oral cavity of the subject with a composition comprising a sweet and caloric food product for a period sufficient to cause a cephalic phase response in the subject.

## Claims

### Claim 1

A method for enhancing exercise performance in a subject, comprising contacting the oral cavity of the subject with a composition comprising a sweet and caloric food product for a period of 5 seconds to 60 seconds without ingestion of the food product, wherein the oral cavity of the subject is contacted with the composition after fasting intervals of at least 6 to 10 minutes.

### Claim 2 (depends on 1)

The method of claim 1, wherein the food product comprises a sugar.

### Claim 3 (depends on 2)

The method of claim 2, wherein the sugar comprises sucrose.

### Claim 4 (depends on 1)

The method of claim 1, wherein the food product contains calories and has a sweetness equivalent to at least 5 wt % sucrose.

### Claim 5 (depends on 1)

The method of claim 1, wherein the oral cavity is first contacted with the composition during the last 20 minutes of the exercise.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition is in the form of a tablet, capsule, lozenge, film, or strip that can completely dissolve in the oral cavity of a human subject within 60 seconds.

### Claim 7 (depends on 1)

The method of claim 1, wherein the composition is in the form of an orally consumable film or strip, wherein the film or strip completely dissolves in the oral cavity within 60 seconds.

### Claim 8 (depends on 7)

The method of claim 7, wherein the film or strip comprises a mucoadhesive polymer.

### Claim 9 (depends on 2)

The method of claim 2, wherein the sugar comprises glucose.