# US 10,307,381 B2 · Patch

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- Number: US 10,307,381 B2
- Document ID: US10307381B2
- Status: Granted
- Kind: B2
- Application number: 15/518,847
- Filed: 2015-10-13
- Published: 2017-08-10
- Granted: 2019-06-04
- Earliest claimed: 2014-10-14
- Assignees: Hisamitsu Pharmaceutical Co., Inc.
- Applicants: Hisamitsu Pharmaceutical Co., Inc.
- Inventors: Junji Noguchi; Eisuke Hatanaka; Hisakazu Kurita; Ryusuke Fudoji; Yasunari Michinaka
- Web page: https://patentgrep.com/patent/US10307381B2

## CPC

- A61K 9/7053: {obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene}
- A61K 9/7061: {Polyacrylates}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 31/485: Morphinan derivatives, e.g. morphine, codeine
- A61K 47/06: Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- C08F 226/02: by a single or double bond to nitrogen
- C08F 226/10: N-Vinyl-pyrrolidone
- C08K 5/092: Polycarboxylic acids
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08K: Use of inorganic or non-macromolecular organic substances as compounding ingredients (paints, inks, varnishes, dyes, polishes, adhesives C09)

## Abstract

A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

## Claims

### Claim 1

A patch, comprising:
a support; and
an adhesive layer disposed on at least one surface of the support,
wherein the adhesive layer comprises a higher aliphatic alcohol having 12 to 20 carbon atoms, a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer, and at least one of butorphanol and a pharmaceutically acceptable salt thereof; wherein the content of the higher aliphatic alcohol is in a range of 3 to 25% by mass based on the total mass of the adhesive layer, the content of the butorphanol and/or pharmaceutically acceptable salt thereof is 4 to 20% by mass based on the total mass of the adhesive layer, the content of the non-cross-linking polyvinylpyrrolidone is in a range of 4 to 20% by mass based on the total mass of the adhesive layer, the non-cross-linking polyvinylpyrrolidone has a K value in a range of 10 to 30; and wherein precipitation of crystals derived from the butorphanol and/or pharmaceutically acceptable salt thereof is suppressed.

### Claim 2 (depends on 1)

The patch according to claim 1, wherein the higher aliphatic alcohol is at least one selected from the group consisting of isostearyl alcohol, octyldodecanol, and oleyl alcohol.

### Claim 3 (depends on 1)

The patch according to claim 1, wherein a content ratio between the butorphanol and/or pharmaceutically acceptable salt thereof and the non-cross-linking polyvinylpyrrolidone is in a range of 1:0.8 to 2.5 in mass ratio.

### Claim 4 (depends on 1)

The patch according to claim 1, wherein the adhesive layer further comprises a styrene-isoprene-styrene block copolymer.

### Claim 5 (depends on 2)

The patch according to claim 2, wherein a content ratio between the butorphanol and/or pharmaceutically acceptable salt thereof and the non-cross-linking polyvinylpyrrolidone is in a range of 1:0.8 to 2.5 in mass ratio.

### Claim 6 (depends on 2)

The patch according to claim 2, wherein the adhesive layer further comprises a styrene-isoprene-styrene block copolymer.

### Claim 7 (depends on 3)

The patch according to claim 3, wherein the adhesive layer further comprises a styrene-isoprene-styrene block copolymer.

### Claim 8 (depends on 5)

The patch according to claim 5, wherein the adhesive layer further comprises a styrene-isoprene-styrene block copolymer.

### Claim 9 (depends on 1)

The patch according to claim 1, wherein the content of the higher aliphatic alcohol is in a range of 3 to 5% by mass based on the total mass of the adhesive layer.