# US 10,307,369 B2 · Antimicrobial polymer for use in ophthalmic implants

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- Number: US 10,307,369 B2
- Document ID: US10307369B2
- Status: Granted
- Kind: B2
- Application number: 15/260,251
- Filed: 2016-09-08
- Published: 2018-03-08
- Granted: 2019-06-04
- Earliest claimed: 2016-09-08
- Applicants: Yichieh Shiuey
- Inventors: Yichieh Shiuey
- Web page: https://patentgrep.com/patent/US10307369B2

## CPC

- A61K 9/0051: {Ocular inserts or implants}
- A61L 27/16: obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/24: Collagen
- A61L 27/26: Mixtures of macromolecular compounds
- A61L 27/3641: {characterised by the site of application in the body (materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60)}
- A61L 27/3687: {characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents}
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61P 31/04: Antibacterial agents
- C08G 18/83: Chemically modified polymers
- C08L 33/00: Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61L 2300/208: Quaternary ammonium compounds
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2430/16: for reconstruction of eye parts, e.g. intraocular lens, cornea
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)

## Abstract

An antimicrobial polymer for use in an ophthalmic implant, includes at least one antimicrobial monomer; and at least one other monomer selected from an acrylic, silicone, vinyl and collagen monomer.

## Claims

### Claim 1

An ophthalmic implant comprising an antimicrobial polymer, comprising:
at least one antimicrobial monomer, wherein the antimicrobial monomer is a quaternary ammonium salt based monomer selected from 1-[12-(methacryloyloxy)dodecyl]-pyridinium bromide (MDPB), methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), 2-methacryloxyethyl dodecyl methyl ammonium bromide (MAE-DB), 2-methacryloxyethyl hexadecyl methyl ammonium bromide (MAE-HB), and bis(2-methacryloxyethyl) dimethyl ammonium bromide (IDMA-1); and
at least one other monomer selected from an acrylic, vinyl and collagen monomer;
and wherein the ophthalmic implant is an artificial cornea, a glaucoma valve, a retinal prosthesis, or an intracorneal implant.

### Claim 2 (depends on 1)

The ophthalmic implant according to claim 1, wherein the antimicrobial polymer is clear, opaque, or translucent.

### Claim 3 (depends on 1)

The ophthalmic implant according to claim 1, wherein the antimicrobial polymer is reversibly deformable.

### Claim 4 (depends on 1)

The ophthalmic implant according to claim 1, wherein the at least one other monomer is an acrylic monomer selected from methyl acrylate (MA) and methyl methacrylate (MMA), or a vinyl monomer selected from a vinyl carbonate and a vinyl carbamate.

### Claim 5

An ophthalmic implant comprising an antimicrobial polymer, comprising:
at least one antimicrobial monomer, wherein the antimicrobial monomer is a quaternary ammonium salt based monomer selected from 1-[12-(methacryloyloxy)dodecyl]-pyridinium bromide (MDPB), methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), 2-methacryloxyethyl dodecyl methyl ammonium bromide (MAE-DB), 2-methacryloxyethyl hexadecyl methyl ammonium bromide (MAE-HB), and bis(2-methacryloxyethyl) dimethyl ammonium bromide (IDMA-1); and
at least one other monomer selected from an acrylic, vinyl and collagen monomer,
wherein the antimicrobial polymer is for use in an ophthalmic implant;
and wherein the ophthalmic implant is an artificial cornea, a glaucoma valve, a retinal prosthesis, or an intracorneal implant.

### Claim 6 (depends on 5)

The ophthalmic implant according to claim 5, wherein the at least one other monomer is an acrylic monomer selected from methyl acrylate (MA) and methyl methacrylate (MMA), or a vinyl monomer selected from a vinyl carbonate and a vinyl carbamate.

### Claim 7 (depends on 5)

The ophthalmic implant according to claim 5, wherein the antimicrobial polymer is clear, opaque, or translucent.

### Claim 8 (depends on 5)

The ophthalmic implant according to claim 5, wherein the antimicrobial polymer is reversibly deformable.

### Claim 9

An ophthalmic implant comprising an antimicrobial polymer, comprising:
at least one antimicrobial monomer, wherein the antimicrobial monomer is a quaternary ammonium salt based monomer selected from 1-[12-(methacryloyloxy)dodecyl]-pyridinium bromide (MDPB), methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), 2-methacryloxyethyl dodecyl methyl ammonium bromide (MAE-DB), 2-methacryloxyethyl hexadecyl methyl ammonium bromide (MAE-HB), and bis(2-methacryloxyethyl) dimethyl ammonium bromide (IDMA-1); and
at least one other monomer selected from an acrylic, vinyl and collagen monomer,
wherein the antimicrobial polymer is formed into an ophthalmic implant.

### Claim 10 (depends on 9)

The ophthalmic implant according to claim 9, wherein the at least one other monomer is an acrylic monomer selected from methyl acrylate (MA) and methyl methacrylate (MMA) or a vinyl monomer selected from a vinyl carbonate and a vinyl carbamate.

### Claim 11 (depends on 9)

The ophthalmic implant according to claim 9, wherein the antimicrobial polymer is clear, opaque, or translucent.

### Claim 12 (depends on 9)

The ophthalmic implant according to claim 9, wherein the antimicrobial polymer is reversibly deformable.

### Claim 13 (depends on 9)

The ophthalmic implant according to claim 9, wherein the ophthalmic implant is an artificial cornea, a glaucoma valve, a retinal prosthesis, or an intracorneal implant.

### Claim 14 (depends on 1)

The ophthalmic implant according to claim 1, wherein the intracorneal implant is an intraocular lens.

### Claim 15 (depends on 5)

The ophthalmic implant according to claim 5, wherein the intracorneal implant is an intraocular lens.

### Claim 16 (depends on 13)

The ophthalmic implant according to claim 13, wherein the intracorneal implant is an intraocular lens.