# US 10,307,366 B2 · Composition and related method for inhibiting moisture loss from skin > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,366 B2 - Document ID: US10307366B2 - Status: Granted - Kind: B2 - Application number: 15/447,634 - Filed: 2017-03-02 - Published: 2017-09-07 - Granted: 2019-06-04 - Earliest claimed: 2016-03-03 - Assignees: Access Business Group International LLC - Applicants: Access Business Group International LLC - Inventors: Ernest H. Brumbaugh; Hilary Cadeau Kindt; Kelly M. Glynn - Web page: https://patentgrep.com/patent/US10307366B2 ## CPC - A61K 8/988: {Honey; Royal jelly, Propolis} - A61K 8/04: Dispersions; Emulsions - A61K 8/345: {containing more than one hydroxy group} - A61K 8/602: {Glycosides, e.g. rutin} - A61Q 15/00: Anti-perspirants or body deodorants (deodorisation of air A61L9/00) - A61Q 19/00: Preparations for care of the skin - A61Q 19/007: {Preparations for dry skin} - A61Q 19/10: Washing or bathing preparations - C11D 17/0047: {Detergents in the form of bars or tablets} - A61K 2800/30: Characterized by the absence of a particular group of ingredients - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - C11D: DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL ## Abstract A method useful for inhibiting moisture loss from skin comprises the step of administering a composition to a subject's skin. The composition comprises a first humectant and a second humectant different from the first humectant. The humectants are useful for increasing moisture content of the subject's skin, specifically the subject's epidermis. The first humectant may comprise a conventional humectant, e.g. glycerol. The second humectant generally comprises certain types of honey. The honey is capable of inhibiting moisture loss from the subject's epidermis and/or moisture loss from the first humectant when the subject is exposed to dry air conditions, e.g. wintertime air having a relative humidity of about 50% or less. Specifically, the second humectant is useful for mitigating adverse effects of the first humectant under certain conditions. Examples of suitable honeys generally include those comprising the flavanone hesperidin, such as orange blossom honey, buckwheat (blossom) honey, or a combination thereof. ## Claims ### Claim 1 A method of inhibiting moisture loss from skin, said method comprising the step of administering a composition to a subject's skin, wherein the composition comprises: I) a first humectant for increasing moisture content of the subject's epidermis; and II) a second humectant different from the first humectant for increasing moisture content of the subject's epidermis; wherein the second humectant comprises honey capable of inhibiting moisture loss from the subject's epidermis and/or moisture loss from the first humectant when the subject is exposed to dry air conditions; wherein the honey is orange blossom honey that is derived from blossoms of the genus Citrus; wherein the composition is free of honey different from the orange blossom honey; and wherein a combination of the first and the second humectants shows increased cell growth as measured by cell size. ### Claim 2 (depends on 1) The method as set forth in claim 1, wherein the orange blossom honey comprises hesperidin. ### Claim 3 (depends on 1) The method as set forth in claim 1, wherein the orange blossom honey comprises a monofloral honey. ### Claim 4 (depends on 1) The method as set forth in claim 1, wherein a majority of the orange blossom honey is derived from blossoms of the species Citrus sinensis. ### Claim 5 (depends on 1) The method as set forth in claim 1, wherein the orange blossom honey is: i) selected from the group of raw honey, strained honey, filtered honey, ultra-sonicated honey, or combinations thereof; ii) unpasteurized honey; or iii) both i) and ii). ### Claim 6 (depends on 1) The method as set forth in claim 1, wherein the second humectant is present in an amount of from about 0.001 to about 99.999 parts by weight based on 100 parts by weight of the composition. ### Claim 7 (depends on 1) The method as set forth in claim 1, wherein the first humectant comprises a sugar alcohol. ### Claim 8 (depends on 1) The method as set forth in claim 1, wherein the first humectant is present in an amount of from about 0.001 to about 99.999 parts by weight based on 100 parts by weight of the composition. ### Claim 9 (depends on 1) The method as set forth in claim 1, wherein the first and second humectants are present in the composition in a weight ratio of from about 12,000:1 to about 1:12,000. ### Claim 10 (depends on 1) The method as set forth in claim 1, wherein the composition is in the form of a topical composition. ### Claim 11 (depends on 1) The method as set forth in claim 1, wherein the subject is mammalian. ### Claim 12 (depends on 1) The method as set forth in claim 1, wherein the composition is substantially free of an occlusive agent different from the first and second humectants. ### Claim 13 (depends on 1) The method as set forth in claim 1, wherein the composition consists essentially of the first and second humectants. ### Claim 14 A method of inhibiting moisture loss from skin, said method comprising the step of administering a composition to a subject's skin, wherein the composition comprises: I) a first humectant comprising glycerol for increasing moisture content of the subject's epidermis; and II) a second humectant comprising orange blossom honey that is derived from blossoms of the genus Citrus for increasing moisture content of the subject's epidermis; wherein the orange blossom honey is capable of inhibiting moisture loss from the subject's epidermis and/or moisture loss from the first humectant when the subject is exposed to air having a relative humidity of no greater than about 50%; wherein the orange blossom honey comprises hesperidin, and the composition is free of honey different from the orange blossom honey; wherein the first and second humectants are present in the composition in a weight ratio of from about 12,000:1 to about 1:12,000; and wherein a combination of the first and the second humectants shows increased cell growth as measured by cell size. ### Claim 15 (depends on 14) The method as set forth in claim 14, wherein a majority of the orange blossom honey is derived from blossoms of the species Citrus sinensis. ### Claim 16 (depends on 14) The method as set forth in claim 14, wherein the composition is completely free of an occlusive agent different from the first and second humectants and wherein the occlusive agent comprises mineral oil. ### Claim 17 (depends on 14) The method as set forth in claim 14, wherein the composition consists essentially of the first and second humectants. ### Claim 18 (depends on 6) The method as set forth in claim 6, wherein the second humectant is present in an amount of from about 0.001 to about 0.1 parts by weight based on 100 parts by weight of the composition. ### Claim 19 (depends on 12) The method as set forth in claim 12, wherein the composition is completely free of an occlusive agent different from the first and second humectants and wherein the occlusive agent comprises mineral oil. ### Claim 20 (depends on 14) The method as set forth in claim 14, wherein the second humectant is present in an amount of from about 0.001 to about 0.1 parts by weight based on 100 parts by weight of the composition.