# US 10,307,357 B2 · Prebiotic oral care compositions containing an alkyl glycoside

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- Number: US 10,307,357 B2
- Document ID: US10307357B2
- Status: Granted
- Kind: B2
- Application number: 15/108,111
- Filed: 2013-12-27
- Published: 2016-11-24
- Granted: 2019-06-04
- Earliest claimed: 2013-12-27
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company; Katholieke Universiteit Leuven; Universiteit Gent
- Inventors: Hans Stettler; Wim Teughels; Marc Quirynen; Nico Boon; Gitte Loozen
- Web page: https://patentgrep.com/patent/US10307357B2

## CPC

- A61K 8/602: {Glycosides, e.g. rutin}
- A61K 31/7004: Monosaccharides having only carbon, hydrogen and oxygen atoms
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/48: Thickener, Thickening system
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The disclosure relates to an oral care composition an effective amount of at least one C?1-4#191 (optionally hydroxylated) alkyl glycoside, e.g., β-methyl-D-galactoside, wherein the glycoside promotes the growth of beneficial endogenous bacteria and negatively affects the growth of endogenous pathogenic strains of bacteria. The disclosure also relates to methods of use, methods of screening, and methods of manufacture of said oral care compositions.

## Claims

### Claim 1

A method of selectively promoting, in an oral cavity of a subject: growth, metabolic activity or colonization of Streptococcus salivarius bacteria that have beneficial effects on oral health; the method comprising contacting the oral cavity with an oral care composition comprising an effective amount of β-methyl-D-galactoside for prebiotic effects of promoting the growth of Streptococcus salivarius, wherein the amount of β-methyl-D-galactoside is selected from 10 μmol/ml, 20 μmol/ml, and 25 μmol/ml;
wherein the composition is a mouthwash, toothpaste, tooth gel, tooth powder, non-abrasive gel, mousse, foam, mouth spray, lozenge, oral tablet, dental implement, or pet care product.

### Claim 2 (depends on 1)

The method of claim 1 wherein the amount of β-methyl-D-galactoside is selected from 20 μmol/ml, and 25 μmol/ml.

### Claim 3 (depends on 1)

The method of claim 1 wherein the amount of β-methyl-D-galactoside is 20 μmol/ml.

### Claim 4 (depends on 1)

The method of claim 1, wherein the composition further comprises bacteria that has beneficial effects on oral health comprising Streptococcus salivarius.

### Claim 5 (depends on 1)

The method of claim 1, wherein the amount of β-methyl-D-galactoside is 25 μmol/ml.