# US 10,307,348 B2 · Single layer tooth whitening system

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- Number: US 10,307,348 B2
- Document ID: US10307348B2
- Status: Granted
- Kind: B2
- Application number: 15/545,434
- Filed: 2016-02-02
- Published: 2018-10-04
- Granted: 2019-06-04
- Earliest claimed: 2015-02-17
- Assignees: Koninklijke Philips N.V.
- Applicants: Koninklijke Philips N.V.
- Inventors: Antonius Wilhelmus Maria De Laat; James Donald Gwyer; Martin John Edwards; Zeynep Sabah
- Web page: https://patentgrep.com/patent/US10307348B2

## CPC

- A61K 8/044: {Suspensions}
- A61K 8/06: Emulsions
- A61K 8/22: Peroxides; Oxygen; Ozone
- A61K 8/31: Hydrocarbons
- A61K 8/42: Amides
- A61K 8/466: {containing sulfonic acid derivatives; Salts}
- A61K 8/60: Sugars; Derivatives thereof
- A61K 8/8117: {Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers}
- A61K 8/8176: {Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers}
- A61K 8/90: Block copolymers (A61K8/89 takes precedence)
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A varnish composition is provided comprising a hydrophilic oral care agent, such as a peroxide material, dispersed in a solution of a film-forming hydrophobic polymer in a non-polar solvent. The solvent is selected so as to be a good solvent for the polymer and to be susceptible to evaporation. The composition can be applied as a single layer varnish, preferably a whitening varnish. E.g., the dispersed hydrophilic peroxide material is an aqueous peroxide solution, such as a hydrogen peroxide solution, whereby the dispersion is an emulsion.

## Claims

### Claim 1

An oral care varnish composition comprising a dispersion of a hydrophilic oral care agent in a solution of a film-forming hydrophobic polymer in a non-polar solvent, wherein the polymer is selected from the group consisting of hydrogenated polyisobutene, Ethylene/Propylene/Styrene Copolymer, Butylene/Ethylene/Styrene Copolymer, alkylated polyvinylpyrrolidone, poly alpha olefins, Hydrogenated Polycyclopentadiene, Polyvinylstearylether, or polystyrene/rubber block-copolymers, and wherein the solvent is selected from the group consisting of pentane, isopentane, heptane, isooctane, isodecane, cyclomethicone (D4), cyclomethicone (D5), C7-9 isoparaffin, C8-9 isoparaffin, and mixtures of these solvents.

### Claim 2 (depends on 1)

A varnish composition according to claim 1, wherein the dispersion is a suspension of hydrophilic particles comprising a solid peroxide.

### Claim 3 (depends on 2)

A varnish composition according to claim 2, wherein the peroxide is selected from carbamide peroxide, PVP-hydrogen peroxide complexes, and mixtures thereof.

### Claim 4 (depends on 1)

A varnish composition according to claim 1, wherein the dispersion is an emulsion of an aqueous solution of hydrogen peroxide.

### Claim 5 (depends on 4)

A varnish composition according to claim 4, comprising at least one emulsifier.

### Claim 6 (depends on 1)

A varnish composition according to claim 1, wherein the solvent is selected from the group consisting of heptane, isooctane, and mixtures thereof, optionally in admixture with isopentane or pentane.

### Claim 7

An oral care varnish composition comprising a dispersion of a hydrophilic oral care agent in a solution of a film-forming hydrophobic polymer in a non-polar solvent, said solvent being volatile and being characterized as a better than theta θ solvent for the polymer, wherein the polymer is a linear triblock copolymer based on styrene and ethylene/butylene, and (SEBS), optionally grafted with maleic anhydride.

### Claim 8 (depends on 1)

A varnish composition according to claim 1, wherein the dispersion comprises an oral care agent selected from the group consisting of sodium fluoride, ACP (amorphous calcium phosphate, including the calcium and phosphate precursors thereof), potassium nitrate, potassium oxalate, phosphates and polyphosphates, monofluorphosphate, aminfluoride, xylitol, chlorhexidine (CHX), cetylpyridiniumchloride (CPC), triclosan (Irgasan), stannous fluoride (SnF2), zinc acetate, silver diamine fluoride, hypochlorite, chlorine dioxide, and iodine.

### Claim 9 (depends on 1)

A cured varnish composition on at least one tooth, obtainable by applying a varnish composition according to claim 1 on said at least one tooth, and curing said composition by evaporation of solvent, said cured composition comprising a hydrophilic oral care agent dispersed in a matrix of a hydrophobic polymer, wherein the hydrophilic oral care agent is present in an aggregate state at least at the surface of the cured composition facing the tooth, and a layer of the hydrophobic polymer is present at least the surface of the cured composition facing away from the tooth.

### Claim 10 (depends on 1)

A method of applying an oral care agent to teeth, the method comprising providing a varnish composition as defined in claim 1 to at least one tooth, and allowing the solvent to evaporate so as to cure the varnish composition.

### Claim 11 (depends on 10)

A method according to claim 10, wherein the oral care agent comprises a peroxide, the method being a teeth whitening method.

### Claim 12 (depends on 10)

A method according to claim 10, wherein the oral care agent comprises an agent selected from the group consisting of sodium fluoride, ACP (amorphous calcium phosphate, including the calcium and phosphate precursors thereof), potassium nitrate, potassium oxalate, phosphates and polyphosphates, monofluorphosphate, aminfluoride, xylitol, chlorhexidine (CHX), cetylpyridiniumchloride (CPC), triclosan (Irgasan), stannous fluoride (SnF2), zinc acetate, silver diamine fluoride, hypochlorite, chlorine dioxide, and iodine.

### Claim 13 (depends on 1)

A cosmetic method of whitening teeth of a subject, preferably a human subject, the method comprising applying a varnish composition according to claim 1 to at least one tooth of said subject, wherein the oral care agent comprises a peroxide, allowing the solvent to evaporate so as to form a cured varnish layer, and allowing the cured varnish layer to stay on said at least one tooth for a desired treatment period.

### Claim 14 (depends on 13)

A cosmetic method according to claim 13, wherein the treatment period is of sufficient length so as to bring about a change in colour of at least 1 ΔE, whereby ΔE is computed according to the formula:
ΔE=√{square root over ((L2*−L1*)2+(a2*−a1*)2+(b2*−b1*)2)}, using the L*, a, *b* values of the teeth, with said values being CIE76 values according to the 1976 definition by the International Commission on Illumination, wherein the values denoted by the subscript 1 are before whitening, and, the values denoted by the subscript 2 are after whitening.