# US 10,307,342 B2 · Oral biofilm inhibitor > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,342 B2 - Document ID: US10307342B2 - Status: Granted - Kind: B2 - Application number: 15/505,411 - Filed: 2015-08-21 - Published: 2017-09-28 - Granted: 2019-06-04 - Earliest claimed: 2015-08-21 - Assignees: National University Corporation Okayama University - Applicants: National University Corporation Okayama University - Inventors: Kazuhiro Omori; Takashi Ito; Shogo Takashiba; Masao Irie - Web page: https://patentgrep.com/patent/US10307342B2 ## CPC - A61K 6/80: Preparations for artificial teeth, for filling teeth or for capping teeth - A61K 6/20: Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish - A61K 6/884: comprising natural or synthetic resins - A61K 8/4926: {having six membered rings} - A61K 9/08: Solutions {(composition of solutions A61K47/00)} - A61K 45/00: Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00 - A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis - A61P 31/04: Antibacterial agents - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract There is provided an oral biofilm inhibitor having an exceptional inhibitory effect on oral biofilm formation. It is an oral biofilm inhibitor comprising a curable composition containing an antimicrobial agent, wherein a compressive strength of a cured product formed by curing the composition is 150 MPa or less, and a content of the antimicrobial agent is 0.001 to 3% by weight. An oral biofilm inhibitor thus obtained is used for inhibiting biofilm formation in an oral cavity by applying a curable composition containing an antimicrobial agent to a dental defect site for allowing the composition to cure at the dental defect site, and then disintegrating the cured composition. ## Claims ### Claim 1 An oral biofilm inhibitor consisting of a curable composition containing cetylpyridinium chloride in paste form and which is at least one of a hydraulic composition, a photocurable composition or a thermosetting composition, wherein a compressive strength of a cured product formed by curing the composition is 10 MPa or less, and a content of the cetylpyridinium chloride is 0.001 to 3% by weight. ### Claim 2 (depends on 1) The oral biofilm inhibitor according to claim 1, used for inhibiting biofilm formation in an oral cavity by applying the curable composition containing the cetylpyridinium chloride to a dental defect site for allowing the composition to cure at the dental defect site, and then disintegrating the cured composition. ### Claim 3 (depends on 2) The oral biofilm inhibitor according to claim 2, wherein the curable composition is again applied to the site where the cured composition has been disintegrated. ### Claim 4 An oral biofilm inhibitor kit comprising a curable composition and cetylpyridinium chloride in paste form and which is at least one of a hydraulic composition, a photocurable composition or a thermosetting composition, wherein a compressive strength of a cured product formed by curing an oral biofilm inhibitor is 10 MPa or less, and the curable composition and the cetylpyridinium chloride are blended for use such that a content of the cetylpyridinium chloride in the oral biofilm inhibitor comes to be 0.001 to 3% by weight. ### Claim 5 An oral biofilm inhibitor kit comprising a curable composition in paste form which is at least one of a hydraulic composition, a photocurable composition or a thermosetting composition and a liquid agent containing water as a main component, wherein at least one of the curable composition and the liquid agent containing water as a main component comprises the cetylpyridinium chloride, a compressive strength of a cured product formed by curing the oral biofilm inhibitor is 10 MPa or less, and the curable composition and the liquid agent are blended for use such that a content of the cetylpyridinium chloride comes to be 0.001 to 3% by weight. ### Claim 6 (depends on 1) A method for producing an oral biofilm inhibitor comprising a curable composition containing cetylpyridinium chloride according to claim 1, comprising blending the curable composition and the cetylpyridinium chloride such that a content of the cetylpyridinium chloride in the oral biofilm inhibitor comes to be 0.001 to 3% by weight. ### Claim 7 (depends on 2) A method for producing an oral biofilm inhibitor comprising a curable composition containing cetylpyridinium chloride according to claim 2, comprising blending the curable composition and the cetylpyridinium chloride such that a content of the cetylpyridinium chloride in the oral biofilm inhibitor comes to be 0.001 to 3% by weight. ### Claim 8 (depends on 3) A method for producing an oral biofilm inhibitor comprising a curable composition containing cetylpyridinium chloride according to claim 3, comprising blending the curable composition and the cetylpyridinium chloride such that a content of the cetylpyridinium chloride in the oral biofilm inhibitor comes to be 0.001 to 3% by weight.