# US 10,307,294 B2 · System and process for neuroprotective therapy for glaucoma > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,294 B2 - Document ID: US10307294B2 - Status: Granted - Kind: B2 - Application number: 15/939,993 - Filed: 2018-03-29 - Published: 2018-08-09 - Granted: 2019-06-04 - Earliest claimed: 2012-05-25 - Assignees: Ojai Retinal Technology, LLC - Applicants: Ojai Retinal Technology, LLC - Inventors: Jeffrey K. Luttrull; Benjamin W. L. Margolis; David B. Chang - Web page: https://patentgrep.com/patent/US10307294B2 ## CPC - A61F 9/00823: {Laser features or special beam parameters therefor} - A61F 9/00821: {for coagulation} - A61N 5/0613: {Apparatus adapted for a specific treatment} - A61B 90/361: {Image-producing devices, e.g. surgical cameras} - A61F 9/008: using laser - A61F 9/00817: {Beam shaping with masks} - A61F 2009/00844: {Feedback systems} - A61F 2009/00863: {Retina} - A61F 2009/00891: {Glaucoma} - A61F 2009/00897: {Scanning mechanisms or algorithms} - A61N 5/067: using laser light - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Providing neuroprotective therapy for glaucoma includes generating a micropulsed laser light beam having parameters and characteristics, including pulse length, power, and duty cycle, selected to create a therapeutic effect with no visible laser lesions or tissue damage to the retina. The laser light beam is applied to retinal and/or foveal tissue of an eye having glaucoma or a risk of glaucoma to create a therapeutic effect to the retinal and/or foveal tissue exposed to the laser light beam without destroying or permanently damaging the retinal and/or foveal tissue and improve function or condition of an optic nerve and/or retinal ganglion cells of the eye. ## Claims ### Claim 1 A system for providing neuroprotective treatment, comprising: a laser console producing a micropulsed laser light beam having characteristics of providing a therapeutic effect to retinal tissue without permanently damaging the retinal tissue, the micropulsed laser light beam characteristics including a wavelength of 532 nm or greater and a duty cycle of less than 10%; an optical mask comprising diffractive optics that the laser light beam passes through to generate a plurality of laser light beams; a coaxial wide-field non-contact digital optical viewing camera projecting the laser light beams to the retinal tissue; and an optical scanning mechanism for controllably directing the light beams onto the retinal tissue to simultaneously apply the plurality of laser light beams to a first treatment area of the retinal tissue, then simultaneously reapply the plurality of laser light beams to the first treatment area after an interval of time less than one second during a single treatment session, and simultaneously apply the plurality of laser light beams to a second treatment area of the retinal tissue spaced apart from the first treatment area during the interval of time. ### Claim 2 (depends on 1) The system of claim 1, wherein the laser light beams are controllably moved by the optical scanning mechanism to different treatment areas between micropulses of the laser light beam, and returned to a previously exposed area within less than one second of a prior exposure until a predetermined number of laser light beam exposures have been achieved in that treatment area. ### Claim 3 (depends on 2) The system of claim 2, wherein the laser light beams are returned to a previously exposed area within 1 to 3 milliseconds of the prior laser light beam exposure. ### Claim 4 (depends on 1) The system of claim 1, wherein the laser console comprises a plurality of laser consoles emitting laser light beams of different wavelengths. ### Claim 5 (depends on 1, 2, 3, 4) The system of any of claim 1 or 2-4, wherein the laser console produces laser light beams having a wavelength between 532 nm and 1300 nm. ### Claim 6 (depends on 5) The system of claim 5, wherein the laser console produces laser light beams having a wavelength of 810 nm. ### Claim 7 (depends on 1, 2, 3, 4) The system of any of claim 1 or 2-4, wherein the optical scanning mechanism controllably moves the light beams until all of the retina has been exposed to the light beams. ### Claim 8 (depends on 1, 2, 3, 4) The system of any claim 1 or 2-4, wherein the plurality of laser light beams are repeatedly applied to the first and second treatment areas until each of the first and second treatment areas receives 50 to 200 laser light applications. ### Claim 9 (depends on 8) The system of claim 8, wherein each laser light application comprises a single pulse of laser light. ### Claim 10 (depends on 1, 2, 3, 4) The system of any of claim 1 or 2-4, wherein the first and second treatment areas are separated by at least a predetermined minimum distance to avoid thermal tissue damage. ### Claim 11 (depends on 4) The system of claim 4, wherein the laser light beams of different wavelengths are simultaneously applied to the retinal tissue by the coaxial wide-field non-contact digital optical viewing camera. ### Claim 12 (depends on 1) The system of claim 1, wherein a pulse length of the laser light beams is 500 milliseconds or less. ### Claim 13 (depends on 1) The system of claim 1, wherein the duty cycle of the laser light beams is 5% or less. ### Claim 14 (depends on 1) The system of claim 1, wherein the laser console produces a laser light beam having an intensity of 100-590 watts per square centimeter.