# US 10,307,292 B2 · Device for adjusting the intraocular pressure > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,292 B2 - Document ID: US10307292B2 - Status: Granted - Kind: B2 - Application number: 14/233,614 - Filed: 2012-07-18 - Published: 2014-05-29 - Granted: 2019-06-04 - Earliest claimed: 2011-07-18 - Assignees: Mor Research Applications Ltd. - Applicants: Gilad Litvin - Inventors: Gilad Litvin - Web page: https://patentgrep.com/patent/US10307292B2 ## CPC - A61F 9/00781: {Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment (drainage implants in general A61M27/002)} - A61F 9/0017: {implantable in, or in contact with, the eye, e.g. ocular inserts} - A61F 13/15252: {compostable or biodegradable} - A61L 31/04: Macromolecular materials - A61L 31/146: {Porous materials, e.g. foams or sponges} - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61M 27/002: {Implant devices for drainage of body fluids from one part of the body to another (intraocular A61F9/00781; middle ear A61F11/202)} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Provided is a device for use in controlling the liquid outflow from the anterior chamber of the eye, methods of draining aqueous humor from the anterior chamber to the intra-orbital space using the device, methods for controlling the liquid outflow from the anterior chamber of the eye and further surgical methods for implanting the presently described device. ## Claims ### Claim 1 An implantable device for controlling liquid outflow from an anterior chamber of an eye, comprising: an implantable elongate body having a first end that is positionable at an anterior chamber of the eye and a second end that is positionable at a conal orbital space of the eye, wherein the elongate body is positionable on the sclera of the eye and is configured to provide a fluid path for draining fluid entering the first end of the elongate body from the anterior chamber to the conal orbital space via the second end, wherein the elongate body comprises at least one first porous swellable polymeric fibrous material and at least one external tubular structure, the at least one first porous swellable fibrous polymeric material being disposed within the at least one external tubular structure. ### Claim 2 (depends on 1) The device according to claim 1, wherein said first porous swellable polymeric fibrous material is non-woven. ### Claim 3 (depends on 1) The device according to claim 1, wherein said first porous swellable polymeric fibrous material is electrospun. ### Claim 4 (depends on 1) The device according to claim 1, having an external at least one layer including at least one second polymeric fibrous material. ### Claim 5 (depends on 1) The device according to claim 1, having an external at least one layer including at least one second polymeric fibrous material wherein said at least one second polymeric fibrous material is a biostable and/or a biocompatible polymer. ### Claim 6 (depends on 1) The device according to claim 1, having an external at least one layer including at least one second polymeric fibrous material wherein said external at least one layer is made of a biodegradable polymer. ### Claim 7 (depends on 1) The device according to claim 1, having an external at least one layer including at least one second polymeric fibrous material wherein said external layer has an elongated shape exceeding the length of said first porous swellable polymeric fibrous material. ### Claim 8 (depends on 1) The device according to claim 1, wherein said first porous swellable polymer fibrous material comprises a water-swellable polymer fibrous material. ### Claim 9 (depends on 1) The device according to claim 1, wherein said first porous swellable polymeric fibrous material is non-woven and has a swellability of at least 50 percent in volume. ### Claim 10 (depends on 1) The device according to claim 1, wherein said first porous swellable polymeric fibrous material is non-woven and has an elasticity of at least 10 percent. ### Claim 11 (depends on 1) The device according to claim 1, wherein said first porous swellable polymeric fibrous material has a porosity of at least 50 percent. ### Claim 12 (depends on 1) The device according to claim 1, wherein said first porous swellable polymeric fibrous material has a water permeability of at least 0.3 ml/cm2/min. ### Claim 13 (depends on 1) The device according to claim 1, comprising at least two first porous swellable polymeric fibrous materials arranged in a layered structure. ### Claim 14 (depends on 1) The device according to claim 1, further comprising at least one pharmaceutical agent incorporated in said first porous swellable polymeric fibrous material. ### Claim 15 (depends on 14) The device according to claim 14, wherein said at least one pharmaceutical agent comprises an antifibrotic agent, an anticoagulant, an antithrombotic agent, an antibiotic agent, an anti-inflammatory agent, a biodegradable material, a pressure lowering agent, an antiangiogenic agent or any combination thereof. ### Claim 16 (depends on 1) A method for controlling the liquid outflow from the anterior chamber of the eye comprising: providing a device according to claim 1; and implanting said device into the eye of a subject so that at least one end of said device is directed towards (or located at) the anterior chamber and its opposite end is directed towards (or located at) the orbital space. ### Claim 17 (depends on 1) The implantable device of claim 1, wherein the first porous swellable polymeric fibrous material comprises pores which increase in volume responsive to an increase of intraocular pressure of fluid at the anterior chamber of the eye for adjusting intraocular pressure in the eye. ### Claim 18 An implantable device for controlling liquid outflow from an anterior chamber of an eye, comprising: an implantable elongate body having a first end that is positionable at an anterior chamber of an eye and a second end that is positionable at a conal orbital space of the eye, wherein the elongate body is positionable on the sclera of the eye and is configured to provide a fluid path for draining fluid entering the first end of the elongate body from the anterior chamber to the conal orbital space via the second end, wherein the elongate body comprises at least one first porous swellable polymeric fibrous material and at least one external tubular structure. ### Claim 19 An implantable device for controlling and maintaining the dynamic equilibrium of aqueous production and liquid outflow from an anterior chamber of an eye, comprising: an implantable elongate body having a first end that is positionable at an anterior chamber of an eye and a second end that is positionable at a conal orbital space of the eye, wherein the elongate body is positionable on the sclera of the eye and is configured to provide a fluid path for draining fluid entering the first end of the elongate body from the anterior chamber to the conal orbital space via the second end, wherein the elongate body comprises at least one first porous swellable polymeric fibrous material and at least one external tubular structure.