# US 10,307,218 B2 · Stereotactic guide assemblies and methods of using same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,218 B2 - Document ID: US10307218B2 - Status: Granted - Kind: B2 - Application number: 14/989,342 - Filed: 2016-01-06 - Published: 2016-07-07 - Granted: 2019-06-04 - Earliest claimed: 2015-01-06 - Assignees: The Cleveland Clinic Foundation - Applicants: The Cleveland Clinic Foundation - Inventors: John T. Gale; Jorge Gonzalez-Martinez; Shawan J. Anthony - Web page: https://patentgrep.com/patent/US10307218B2 ## CPC - A61B 90/10: for stereotaxic surgery, e.g. frame-based stereotaxis - A61B 90/11: with guides for needles or instruments, e.g. arcuate slides or ball joints - A61M 27/006: {Cerebrospinal drainage; Accessories therefor, e.g. valves} - A61N 1/0529: {Electrodes for brain stimulation} - A61B 2090/103: {Cranial plugs for access to brain} - A61B 2090/376: {using X-rays, e.g. fluoroscopy} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract One aspect of the present disclosure relates to a stereotactic guide assembly comprising an implantable body and a fastener. The implantable body can have an interior chamber and a first passageway that extends through the implantable body into communication with the interior chamber. At least a portion of the interior chamber can be defined by a first coupling feature. The fastener can be configured to fit in the interior chamber. The fastener can have a second passageway extending therethrough, and a second coupling feature adapted to releasably engage the first coupling feature. ## Claims ### Claim 1 A stereotactic guide assembly comprising: an implantable body having an interior chamber and a first passageway that extends through the implantable body into communication with the interior chamber, the implantable body having a stepped-down configuration wherein the implantable body comprises an upper portion connected to a lower portion, the upper portion at least partially defined by a first coupling feature and having an outer diameter greater than an outer diameter of the lower portion, the implantable body sized and dimensioned to fit within a burr hole located in a cranium of a human subject; and a fastener configured to fit in the interior chamber, the fastener having a second passageway extending therethrough and a second coupling feature adapted to releasably engage the first coupling feature. ### Claim 2 (depends on 1) The stereotactic guide assembly of claim 1, wherein the portion of the interior chamber defined by a first coupling feature comprises a first series of threads, and the second coupling feature comprises a second series of threads that are complementary to the first series of threads. ### Claim 3 (depends on 1) The stereotactic guide assembly of claim 1, wherein the fastener further includes an upper receiving surface adapted to mate with a complementary surface of a fastener insertion tool. ### Claim 4 (depends on 1) The stereotactic guide assembly of claim 1, further comprising a cranial fixation ring adapted to mate with the implantable body and thereby secure the implantable body within a burr hole. ### Claim 5 (depends on 4) The stereotactic guide assembly of claim 4, wherein the cranial fixation ring further comprises: a guide portion adapted to mate with an upper surface of the implantable body; and a plurality of radially spaced apart attachment members, each of which is connected to the guide portion and adapted to contact separate portions of a cranium located adjacent the burr hole. ### Claim 6 A stereotactic guide assembly comprising: an implantable body having an interior chamber and a first passageway that extends through the implantable body into communication with the interior chamber, the implantable body having a stepped-down configuration wherein the implantable body comprises an upper portion connected to a lower portion, the upper portion at least partially defined by an external coupling feature and having an outer diameter greater than an outer diameter of the lower portion, the implantable body sized and dimensioned to fit within a burr hole located in a cranium of a human subject; and a fastener configured to fit in the interior chamber, the fastener having a second passageway extending therethrough and an internal coupling feature adapted to releasably engage the external coupling feature. ### Claim 7 (depends on 6) The stereotactic guide assembly of claim 6, wherein the external coupling feature is a threaded section that is complementary to a threaded section of the internal coupling feature. ### Claim 8 (depends on 6) The stereotactic guide assembly of claim 6, wherein an upper portion of the external coupling feature has a beveled edge. ### Claim 9 (depends on 6) The stereotactic guide assembly of claim 6, wherein an outer surface of the fastener and an inner surface of the interior chamber are threaded. ### Claim 10 (depends on 6) The stereotactic guide assembly of claim 6, further comprising a sealing ring configured to fit within the second passageway of the fastener. ### Claim 11 (depends on 6) The stereotactic guide assembly of claim 6, further comprising a cover that is sized and dimensioned to cover the implantable body when implanted in a burr hole. ### Claim 12 (depends on 11) The stereotactic guide assembly of claim 11, wherein the cover includes a rim having a notch adapted to receive an electrical lead. ### Claim 13 (depends on 6) The stereotactic guide assembly of claim 6, further comprising a locking mechanism configured to engage the fastener and prevent or minimize movement of the fastener when the fastener is seated within the implantable body. ### Claim 14 (depends on 13) The stereotactic guide assembly of claim 13, wherein the locking mechanism comprises a plurality of C-shaped clips adapted to separately wedge between an inner surface of the interior chamber and an outer surface of the fastener.