# US 10,307,075 B2 · External standard reference system of type inserted into coil of human magnetic resonance imaging equipment > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,307,075 B2 - Document ID: US10307075B2 - Status: Granted - Kind: B2 - Application number: 14/872,805 - Filed: 2015-10-01 - Published: 2017-02-23 - Granted: 2019-06-04 - Earliest claimed: 2015-08-18 - Assignees: The Catholic University of Korea Industry-Academic Cooperation Foundation - Applicants: The Catholic University of Korea Industry-Academic Cooperation Foundation - Inventors: Bo-Young Choe; Kyu-Ho Song; Do-Wan Lee - Web page: https://patentgrep.com/patent/US10307075B2 ## CPC - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 5/0042: {for the brain} - G01R 33/58: Calibration of imaging systems, e.g. using test probes {, Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material} - G01R 35/00: Testing or calibrating of apparatus covered by the other groups of this subclass - G01R 33/46: NMR spectroscopy - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) ## Abstract The present invention relates to an external standard reference system of a type inserted into the coil of a human magnetic resonance imaging equipment, and more specifically, to a system capable of analyzing metabolic components (quantity of metabolites) in a human body without an error and a limited range using an external standard reference analysis method, in order to enhance accuracy of diagnosis by utilizing magnetic resonance spectroscopy of the human magnetic resonance imaging equipment. A system for evaluating performance of magnetic resonance spectroscopy includes an outer container for inserting an RF coil and provided with a plurality of holes; a plurality of inner containers arranged to be inserted into the plurality of holes respectively and capable of being filled with metabolites different from each other in at least a type or a concentration; and a frame for fixing a head of an object arranged inside the outer container. ## Claims ### Claim 1 An external standard reference structure insertable into magnetic resonance imaging equipment for evaluating performance of magnetic resonance spectroscopy, the structure comprising: an outer container comprising an opening and a plurality of holes surrounding the opening, the opening to receive a head of an object; and a plurality of inner containers insertable into the plurality of holes respectively, the inner containers capable of being filled with metabolites that are different from each other in at least a type or a concentration; wherein performance of the magnetic resonance spectroscopy is capable of being evaluated via the magnetic resonance imaging equipment using the structure in association with a following mathematical expression, Cmb=Ccp×(Smp/Scp)×(fT1cp/fT1mp)×(fT2cp/fT2mp)×(Ncp/Nmp), wherein Cmb denotes concentration of a human brain metabolite, Ccp denotes concentration of a metabolite, Smp denotes a peak area of a brain metabolite, Scp denotes a peak area in an inner container, fT1mp denotes T1 relaxation time of a brain metabolite, fT1cp denotes T1 relaxation time of a metabolite in an inner container, fT2mp denotes T2 relaxation time of a brain metabolite, fT2cp denotes T2 relaxation time of a metabolite in an inner container, Nmp denotes the number of transients acquired in a voxel for acquiring a brain metabolite, and Ncp denotes the number of transients acquired in each voxel in an inner container. ### Claim 2 (depends on 1) The structure according to claim 1, wherein vertical lengths of at least some of the plurality of inner containers are different from each other. ### Claim 3 (depends on 1) The structure according to claim 1, wherein the inner containers are filled with the metabolites. ### Claim 4 (depends on 3) The structure according to claim 3, wherein the metabolites are different from each other in at least the type or the concentration. ### Claim 5 (depends on 3) The structure according to claim 3, wherein the type and the concentration of at least some of the metabolites filled in the plurality of inner containers are replaceable. ### Claim 6 (depends on 1) The structure according to claim 1, wherein the plurality of inner containers is six. ### Claim 7 (depends on 1) The structure according to claim 1, wherein each of the inner containers is filled with metabolites comprising 12.5 mM of N-acetyl-aspartate [NAA], 12.5 mM of glutamate [Glu], 10 mM of creatine [Cr], 7.5 mM of myo-Inositol [mIns], 5.0 mM of lactate [Lac], and 3.0 mM of choline [Cho]. ### Claim 8 (depends on 1) The structure according to claim 1, wherein the outer container is configured to receive a coil in association with an inside surface of the opening of the outer container or an outside surface of the outer container surrounding the plurality of holes. ### Claim 9 A system to evaluate performance of magnetic resonance spectroscopy, the system comprising: an external standard reference structure comprising: an outer container having an opening and a plurality of holes surrounding the opening, the opening to receive a head of an object; and a plurality of inner containers insertable into the plurality of holes respectively, the inner containers capable of being filled with metabolites that are different from each other in at least a type or a concentration; and magnetic resonance imaging equipment into which the external standard reference structure is capable of being inserted to evaluate the performance of magnetic resonance spectroscopy using the external standard reference structure in association with a following mathematical expression, Cmb=Ccpλ(Smp/Scp)×(fT1cp/fT1mp)×(fT2cp/fT2mp)×(Ncp/Nmp), wherein Cmb denotes concentration of a human brain metabolite, Ccp denotes concentration of a metabolite, Smp denotes a peak area of a brain metabolite, Scp denotes a peak area in an inner container, fT1mp denotes T1 relaxation time of a brain metabolite, fT1cp denotes T1 relaxation time of a metabolite in an inner container, fT2mp denotes T2 relaxation time of a brain metabolite, fT2cp denotes T2 relaxation time of a metabolite in an inner container, Nmp denotes the number of transients acquired in a voxel for acquiring a brain metabolite, and Ncp denotes the number of transients acquired in each voxel in an inner container. ### Claim 10 (depends on 9) The system according to claim 9, wherein vertical lengths of at least some of the plurality of inner containers are different from each other. ### Claim 11 (depends on 9) The system according to claim 9, wherein the inner containers are filled with the metabolites. ### Claim 12 (depends on 11) The system according to claim 11, wherein the metabolites are different from each other in at least the type or the concentration. ### Claim 13 (depends on 11) The system according to claim 11, wherein the type and the concentration of at least some of the metabolites filled in the plurality of inner containers are replaceable. ### Claim 14 (depends on 9) The system according to claim 9, wherein the plurality of inner containers is six. ### Claim 15 (depends on 9) The system according to claim 9, wherein each of the inner containers is filled with metabolites comprising 12.5 mM of N-acetyl-aspartate [NAA], 12.5 mM of glutamate [Glu], 10 mM of creatine [Cr], 7.5 mM of myo-Inositol [mIns], 5.0 mM of lactate [Lac], and 3.0 mM of choline [Cho]. ### Claim 16 (depends on 9) The system according to claim 9, wherein the outer container is configured to receive a coil in association with an inside surface of the opening of the outer container or an outside surface of the outer container surrounding the plurality of holes.