# US 10,307,070 B2 · Intravascular pressure and flow data diagnostic systems, devices, and methods

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- Number: US 10,307,070 B2
- Document ID: US10307070B2
- Status: Granted
- Kind: B2
- Application number: 14/678,973
- Filed: 2015-04-04
- Published: 2015-11-05
- Granted: 2019-06-04
- Earliest claimed: 2014-04-04
- Assignees: St. Jude Medical Coordination Center Bvba
- Applicants: St. Jude Medical Systems AB
- Inventors: Eugen Veszelei; Fredrik Lundgren
- Web page: https://patentgrep.com/patent/US10307070B2

## CPC

- A61B 5/027: using catheters
- A61B 5/02055: {Simultaneously evaluating both cardiovascular condition and temperature}
- A61B 5/0215: by means inserted into the body
- A61B 5/02158: {provided with two or more sensor elements}
- A61B 5/026: Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)}
- A61B 5/029: Measuring blood output from the heart, e.g. minute volume
- A61B 5/7225: {Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation (input circuits for detecting, measuring, or recording bioelectric or biomagnetic signals A61B5/30; specific diagnostic methods using bioelectric or biomagnetic signals A61B5/316)}
- A61B 5/7278: {Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals}
- A61B 5/743: {Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots}
- A61B 5/7475: {User input or interface means, e.g. keyboard, pointing device, joystick}
- A61B 5/01: Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20)
- A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance}
- A61B 5/0245: by using sensing means generating electric signals, {i.e. ECG signals}
- A61B 5/6851: {Guide wires}
- A61B 2560/0214: of power generation or supply
- A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors
- A61B 2560/0475: Special features of memory means, e.g. removable memory cards
- A61B 2562/0247: Pressure sensors
- A61B 2562/0271: Thermal or temperature sensors
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

In part, the disclosure relates to computer-based methods, devices, and systems suitable for performing intravascular data analysis and measurement of various types of data such as pressure and flow data. The disclosure relates to probes and methods suitable for determining an event in a cardiac cycle such as flow threshold such as a peak flow, a fraction thereof, other intravascular parameters or a point in time during which peak flow or a change in one of the parameters occurs. An exemplary probe includes one or more of a pressure sensor, a resistor, a flow sensor and can be used to generate diagnostic data based upon measured intravascular and other parameters. In part, the disclosure relates to methods and systems suitable for determining a coronary flow reserve value in response to one or more of intravascular pressure and flow data or data otherwise correlated therewith.

## Claims

### Claim 1

A method of collecting blood vessel related data comprising:
storing, in one or more memory devices in electronic communication with an intravascular data processing system, guide wire-based intravascular probe data;
measuring a first electrical signal associated with a first resistor and a second resistor disposed in a region of a blood vessel, wherein the first resistor is sensitive to temperature;
measuring a second electrical signal associated with the second resistor disposed in the region of the blood vessel, wherein the second resistor is sensitive to pressure;
determining, using an intravascular data processing system, a transfer function using the stored guide wire-based intravascular probe data, the transfer function having a flow parameter as an output;
determining, using an intravascular data processing system, a blood pressure value for the region of the blood vessel using one or more of the first and second electrical signals;
determining, using an intravascular data processing system, a blood temperature value for the region of the blood vessel using one or more of the first and second electrical signals;
determining, using an intravascular data processing system, a blood flow value for the region of the blood vessel by measuring changes in blood temperature using one or more of the first and second electrical signals and the transfer function; and
displaying a pressure versus flow curve for the region of the blood vessel.

### Claim 2 (depends on 1)

The method of claim 1 wherein the transfer function relates the flow parameter and an excitation voltage.

### Claim 3 (depends on 1)

The method of claim 1 wherein the transfer function relates the flow value and a temperature of one or more of the first resistor and the second resistor.

### Claim 4 (depends on 1)

The method of claim 1 further comprising identifying, using an intravascular pressure and flow monitoring system, one or more of an occurrence of a maximum flow, a minimum flow, and a relative extremum of flow and correlating such an occurrence with an intravascular or cardiac event.

### Claim 5 (depends on 1)

The method of claim 1 wherein the transfer function is T(x), wherein x is flow, is of the form T(x)=a+b*xc, wherein a, b and c are constants.

### Claim 6 (depends on 5)

The method of claim 5 wherein c varies based on position of the guide wire-based probe in the blood vessel.

### Claim 7 (depends on 1)

The method of claim 1 further comprising displaying one or more trajectories or signatures generated in response to intravascular probe data with respect to one or more positions in the blood vessel.

### Claim 8 (depends on 1)

The method of claim 1 further comprising determining one or more temperature values using a second electrical signal from a measurement circuit formed from the guide wire-based probe and an interface device, wherein the interface device receives signals from the guide wire-based probe indicative of flow and pressure at one or more locations along a blood vessel.

### Claim 9 (depends on 1)

The method of claim 1 further comprising tuning a temperature signal received from the guide wire-based probe to find a maximum, a minimum, or other value.

### Claim 10 (depends on 1)

The method of claim 1 further comprising
receiving electrical signals correlated with temperature changes of an intravascular guide wire-based probe in thermal communication with the blood vessel, the temperature changes correlated with changes in a flow during one or more cardiac cycles, and
determining a peak blood flow value from the electrical signals correlated with temperature changes.

### Claim 11 (depends on 1)

The method of claim 1, further comprising calculating a pressure difference using the blood pressure value and another blood pressure value for a plurality of heartbeats.

### Claim 12 (depends on 1)

The method of claim 1 further comprising displaying, on a user display, diagnostic information about the blood vessel, wherein the diagnostic information comprises one or more of a pressure ratio, a pressure difference, a plot of pressure ratio, or a plot of a pressure-difference.

### Claim 13 (depends on 1)

The method of claim 1 wherein the intravascular data processing system comprises one or more computing devices.

### Claim 14 (depends on 1)

The method of claim 1 wherein the guide wire-based intravascular probe comprises the first resistor and the second resistor.

### Claim 15 (depends on 14)

The method of claim 14 wherein one of the first resistor and the second resistor is a reference resistor and the other resistor of the first resistor and the second resistor is a pressure sensing resistor.

### Claim 16 (depends on 1)

The method of claim 1 wherein the second resistor is also sensitive to temperature.