# US 10,306,909 B2 · Amino acid based diet with improved taste

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- Number: US 10,306,909 B2
- Document ID: US10306909B2
- Status: Granted
- Kind: B2
- Application number: 15/321,915
- Filed: 2015-06-30
- Published: 2017-05-25
- Granted: 2019-06-04
- Earliest claimed: 2014-07-01
- Assignees: N.V. Nutricia
- Applicants: N.V. Nutricia
- Inventors: Jonathan Rason; Carole Springett
- Web page: https://patentgrep.com/patent/US10306909B2

## CPC

- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A23L 2/52: Adding ingredients (adding preservatives A23B70/10)
- A23L 33/12: Fatty acids or derivatives thereof
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/175: Amino acids
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine
- A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K 38/16: Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof {(enzyme inhibitors A61K38/005)}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present invention is based on the finding that free amino acids can both negatively or positively influence overall taste of free amino acid-based enteral nutritional compositions, and the amino acids can thus be categorized. A striking balance of both categories of amino acids to arrive at amino acid-based nutritional composition with improved taste, yet not compromising the (regulatory) dietary restrictions on essential amino acids and conditionally essential amino acids.

## Claims

### Claim 1

An enteral nutritional composition, comprising up to 75 wt % glycomacropeptide (GMP), based on the weight of all proteinaceous matter, and free amino acids, wherein:
(a) 50-80 wt % of the weight of total free amino acids in the composition is comprised of the sum of the amounts of free amino acids selected from the group consisting of alanine, cysteine, glutamine, glutamic acid, proline, serine, threonine, and tyrosine; and
(b) 20-40 wt % of the weight of total free amino acids in the composition is comprised of the sum of the amounts of free amino acids selected from the group consisting of arginine, aspartic acid, asparagine, histidine, isoleucine, lysine, methionine, tryptophan, and valine,
wherein the composition comprises, as free amino acids, at least 0-10 g phenylalanine, 4-8 g valine, 2.5-11 g threonine, 0.7-3 g tryptophan, 2.5-6 g isoleucine, 1.5-4 g methionine, 6.5-8.5 g leucine, 3-6 g lysine, and 1.5-3 g histidine, per 100 g free amino acids in the composition,
wherein the sum of the amount of free amino acids selected from the group consisting of arginine, aspartic acid, asparagine, histidine, isoleucine, leucine, lysine and methionine is between 25 and 35 wt %, based on the total free amino acids in the composition.

### Claim 2 (depends on 1)

The composition according to claim 1, comprising as free amino acids 0-10 g phenylalanine, 4-6.5 g valine, 7-11 g threonine, 0.7-3 g tryptophan, 3.5-6 g isoleucine, 1.5-4 g methionine, 6.5-8.5 g leucine, 3-6 g lysine, and 1.5-3 g histidine, per 100 g free amino acids in the composition.

### Claim 3 (depends on 1)

The composition according to claim 1, comprising as free amino acids 0-2 g phenylalanine, 4-6 g valine, 7.5-9 g threonine, 0.7-1.5 g tryptophan, 6.5-7.5 g isoleucine, 1.5-2.5 g methionine, 6.5-7.5 g leucine, 3.5-5 g lysine, and 1.5-2.5 g histidine, per 100 g free amino acids in the composition.

### Claim 4 (depends on 1)

The composition according to claim 1, comprising less than 0.5 g phenylalanine per 100 g free amino acids.

### Claim 5 (depends on 1)

The composition according to claim 1, wherein at least 80 wt % of the proteinaceous matter comprised in the composition is formed from free amino acids.

### Claim 6 (depends on 5)

The composition according to claim 5, wherein at least 90 wt % of the proteinaceous matter comprised in the composition is formed from free amino acids.

### Claim 7 (depends on 1)

The composition according to claim 1, wherein the weight ratio of the sum of the amounts of free amino acids selected from the group consisting of alanine, cysteine, glutamine, glutamic acid, proline, serine, threonine and tyrosine to the sum of the amounts of free amino acids selected from the group consisting of arginine, aspartic acid, asparagine, histidine, isoleucine, leucine, lysine, methionine, tryptophan and valine in the composition ranges between 60:40 and 75:25.

### Claim 8 (depends on 7)

The composition according to claim 7, wherein the weight ratio of the sum of the amounts of free amino acids selected from the group consisting of alanine, cysteine, glutamine, glutamic acid, proline, serine, threonine and tyrosine to the sum of the amounts of free amino acids selected from the group consisting of arginine, aspartic acid, asparagine, histidine, isoleucine, leucine, lysine, methionine, tryptophan and valine in the composition ranges between 65:35 and 70:30.

### Claim 9 (depends on 1)

The composition according to claim 1, comprising 5-7 g cystine, 10-14 g glycine, 8-10 g tyrosine as free amino acids, per 100 g free amino acids in the composition.

### Claim 10 (depends on 9)

The composition according to claim 9, comprising 5.5-6.5 g cystine, 10-14 g glycine, 8-10 g tyrosine as free amino acids, per 100 g free amino acids in the composition.

### Claim 11 (depends on 1)

The composition according to claim 1, wherein the composition further comprises digestible carbohydrates.

### Claim 12

The composition according to 11, wherein the digestible carbohydrates comprise polysaccharides selected from the group consisting of starch, maltodextrin, and a mixture thereof.

### Claim 13 (depends on 1)

A method for preventing, treating or reducing the risk of developing a metabolic disorder in a subject, comprising enterally administering to said subject an effective amount of a composition according to claim 1.

### Claim 14 (depends on 13)

The method according to claim 13, wherein the subject suffers from a metabolic disorder selected from the group consisting of phenylketonuria, homocystinuria, maple syrup urine disease, tyrosinaemia, propionic acidaemia, methylmalonic acidaemia, isovaleric acidaemia, urea cycle disorders and glutaric aciduria, particularly phenylketonuria.

### Claim 15 (depends on 1)

A method for improving gut health, and/or stimulating catch-up growth in a child suffering from a metabolic disease selected from the group consisting of phenylketonuria, homocystinuria, maple syrup urine disease, tyrosinaemia, propionic acidaemia, methylmalonic acidaemia, isovaleric acidaemia, urea cycle disorders and glutaric aciduria, comprising enterally administering to the child an effective amount of a composition according to claim 1.

### Claim 16 (depends on 1)

The composition according to claim 1, comprising substantially no phenylalanine in the composition.

### Claim 17 (depends on 1)

The composition according to claim 1, which is an infant formula.

### Claim 18

An enteral nutritional composition, comprising up to 75 wt % glycomacropeptide (GMP), based on the weight of all proteinaceous matter, and as free amino acids about 13 g alanine, about 6 g arginine, about 1 g of the sum of aspartic acid and asparagine, about 6 g cystine, about 10 g of the sum of glutamic acid and glutamine, about 12 g glycine, about 2 g histidine, about 4 g isoleucine, about 7 g leucine, about 4 g lysine, about 2 g methionine, about 7 g proline, about 3 g serine, about 8 g threonine, about 1 g tryptophan, about 9 g tyrosine, and about 5 g valine, per 100 g free amino acids, wherein the term “about” represents a 20% weight variation.

### Claim 19

An enteral nutritional composition, comprising up to 75 wt % glycomacropeptide (GMP), based on the weight of all proteinaceous matter, and free amino acids, wherein:
(a) 50-80 wt % of the weight of total free amino acids in the composition is comprised of the sum of the amounts of free amino acids selected from the group consisting of alanine, cysteine, glutamine, glutamic acid, proline, serine, threonine, and tyrosine; and
(b) 20-40 wt % of the weight of total free amino acids in the composition is comprised of the sum of the amounts of free amino acids selected from the group consisting of arginine, aspartic acid, asparagine, histidine, isoleucine, lysine, methionine, tryptophan, and valine,
wherein the composition comprises, as free amino acids, at least 0-10 g phenylalanine, 4-8 g valine, 2.5-11 g threonine, 0.7-3 g tryptophan, 2.5-6 g isoleucine, 1.5-4 g methionine, 6.5-8.5 g leucine, 3-6 g lysine, 1.5-3 g histidine, 5-7 g cystine, 10-14 g glycine, and 8-10 g tyrosine, per 100 g free amino acids in the composition.