# US 10,306,887 B2 · Composition and methods for modulation of the octopamine receptor and its homologs

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- Number: US 10,306,887 B2
- Document ID: US10306887B2
- Status: Granted
- Kind: B2
- Application number: 15/501,504
- Filed: 2015-08-04
- Published: 2017-08-10
- Granted: 2019-06-04
- Earliest claimed: 2014-08-05
- Assignees: Board of Regents, The University of Texas Systems
- Applicants: Kyung-an Han
- Inventors: Kyung-an Han
- Web page: https://patentgrep.com/patent/US10306887B2

## CPC

- A01N 47/22: O-Aryl or S-Aryl esters thereof
- A01N 33/04: Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
- A01N 33/06: Nitrogen directly attached to an aromatic ring system
- A01N 43/50: 1,3-Diazoles; Hydrogenated 1,3-diazoles
- A01N 45/02: having three carbocyclic rings
- C07K 14/43563: {from insects}
- C12Q 1/6897: involving reporter genes operably linked to promoters
- G01N 33/5041: {involving analysis of members of signalling pathways}
- G01N 2333/43552: from insects
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Embodiments of the invention are directed of compositions for activation or inhibition of the Octβ2 receptor and uses thereof. The inventors have discovered that the beta adrenergic-like octopamine receptor Octβ2 serves as a key signaling molecule for ovulation and recruits protein kinase A and Ca2+/calmodulin-sensitive kinase II as downstream effectors for this activity. Octβ2R homozygous mutant females are sterile, and display normal courtship, copulation, sperm storage and post-mating rejection behavior but were unable to lay eggs.

## Claims

### Claim 1

A method of reducing fecundity in an insect comprising administering to an insect phentolamine.

### Claim 2 (depends on 1)

The method of claim 1, further comprising administering an OAMB antagonists, a PKA inhibitor, a CaMKII inhibitor, or combinations thereof.

### Claim 3 (depends on 1)

The method of claim 1, wherein the Octβ2R antagonist is formulated in an insect control composition.

### Claim 4 (depends on 3)

The method of claim 3, wherein the insect control composition further comprises an insect toxicant.

### Claim 5 (depends on 3)

The method of claim 3, wherein the insect control composition further comprises an additional bioactive compound.

### Claim 6 (depends on 1)

The method of claim 1, wherein the insect is medfly, fruit fly, or mosquito.

### Claim 7 (depends on 1)

The method of claim 1, wherein the insect is a spotted wing drosophila.