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AssigneeJeju National University Industry-Academic Cooperation Foundation
InventorsSe Pill Park, Young Sok Choi, Eun Young Kim, Young Ho Kim, Hyun Seok Hong, Chan Kyu Park, Mi Seon Park
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The present invention relates to expression cassettes and vectors comprising Alzheimer's disease-related genes and a cell line transformed by the disclosed expression cassettes and vectors, and more specifically, the expression cassettes according to the present invention comprise amyloid precursor protein (APP), Tau protein, and presenilin-1 (PS1) genes associated with Alzheimer's disease so that mutant genes thereof can be simultaneously expressed. Additionally, the present invention relates to a cell line transformed by the disclosed expression cassettes or vectors comprising APP, Tau protein, and PS1 genes, and further, to an animal model transformed by the vectors or cell line.
A recombinant expression vector comprising an expression cassette associated with an Alzheimer's disease (AD), the expression cassette comprising (a) a mutant amyloid precursor protein (APP) gene for encoding an APP, (b) a mutant tau gene for encoding a tau protein, (c) a mutant presenilin 1 (PS1) gene for encoding a PS1 and (d) a neuron-specific promoter for controlling the mutant APP gene, the mutant tau gene and the mutant PS1 gene all at once,
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