Sharply resolving labeled protein molecular weight standards
AssigneeLife Technologies Corporation
InventorsRoumen Bogoev, Douglas Kang
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Abstract
Pre-labeled protein standards useful in electrophoresis that have sharp, consistent separation characteristics that are substantially the same as those of their unlabeled counterparts are provided. The invention provides pre-labeled protein standard sets that include a plurality of labeled proteins that are labeled on a first amino acid, in which side reactions of the label with amino acids not targeted for labeling are reduced.
Claims18
A pre-labeled protein standard set comprising a plurality of labeled proteins, wherein one or more of the plurality of labeled proteins is a selectively labeled protein comprising a labeling compound on a first or a target amino acid residue and lacks amino acid residues of a second or non-target amino acid residue that can react with said labeling compound,
- wherein at least one or more of said plurality of labeled proteins has an amino acid sequence that is at least 95% identical to the amino acid sequence selected from the group consisting of SEQ ID NOs:
- 11, 12, 14, 15, 16, 17, 38, 39, and 41.
Dependencies are inferred from the claim text.