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US 10,301,608 B2Granted
Variants of phosphotriesterase for the hydrolysis and detoxification of nerve agents
AssigneeThe Texas A&M University System
InventorsFrank M. Raushel, Andrew N. Bigley
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Abstract
Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.
Claims1
A synthetic amino acid sequence comprising the amino acid sequence of L7ep-3a (SEQ ID NO:
- 5) and functioning by hydrolyzing an organophosphate nerve agent.
Dependencies are inferred from the claim text.